Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/6526
Title: Central Skull Base Osteomyelitis in Queensland, Australia, 2010-2020
Authors: Eustace, Matthew B
Braddick, Maxwell
Alcorn, Kylie 
Choong, Keat 
Satyaputra, Ferris
Siebert, David
Smith, Simon 
Sommerville, Ryan 
McCarthy, Kate 
Issue Date: 2024
Publisher: Infectious Diseases Society of America
Source: Matthew B Eustace, Maxwell Braddick, Kylie Alcorn, Keat Choong, Ferris Satyaputra, David Siebert, Simon Smith, Ryan Sommerville, Kate McCarthy, Central Skull Base Osteomyelitis in Queensland, Australia, 2010–2020, Open Forum Infectious Diseases, Volume 11, Issue 10, October 2024, ofae614, https://doi.org/10.1093/ofid/ofae614
Journal Title: Open forum infectious diseases
Journal: Open Forum Infectious Diseases
Abstract: Central skull base osteomyelitis (CSBO) is an incompletely defined, life-threatening infection of the bones of the cranial vault. We describe the clinical features and outcomes of CSBO in Queensland, Australia, over an 11-year period. Medical record coding enquiries identified cases of CSBO across 6 tertiary hospitals in Queensland, Australia, from January 2010 to December 2020. Epidemiological, demographic, diagnostic, management, and outcome data were collected from each identified case. Twenty-two cases of CSBO were identified within the study period; the median age was 73 years with a male predominance (73%). High rates of comorbid disease were detected, with a median Charlson Comorbidity Index score of 5. Diabetes mellitus was the most frequently observed condition. Six cases had bone sampling for microbiological diagnosis while the remainder had superficial sampling of contiguous structures. The most common pathogen isolated was Pseudomonas aeruginosa followed by Staphylococcus aureus, with only 1 case of fungal infection. This series demonstrated a mortality rate of 31.8%, with 45.5% of cases left with long-term sequelae including persistent pain and cranial nerve deficits. Four key observations emerged in this series: (1) advanced age and diabetes mellitus are common risk factors for CSBO, (2) limited surgical intervention occurred, (3) microbiological diagnoses relied primarily on superficial sampling, and (4) significant mortality and morbidity was observed. Prospective studies are needed to better understand the optimal approach to the diagnosis and management of CSBO and to improve clinical outcomes.
Description: Cairns & Hinterland Hospital and Health Service (CHHHS) affiliated author: Simon Smith
DOI: 10.1093/ofid/ofae614
Keywords: Australia;bacterial infection;fungal infection;osteomyelitis;skull base
Type: Article
Appears in Sites:Cairns & Hinterland HHS Publications

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