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Title: Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia
Authors: Smith, Simon 
Marquardt, Tonia 
Jennison, Amy V 
D'Addona, Andrew 
Stewart, James 
Yarwood, Trent 
Ho, Jennifer 
Binotto, Enzo 
Harris, Julian 
Fahmy, Mark 
Esmonde, Juliet 
Richardson, Megan 
Graham, Rikki M A
Gair, Richard 
Ariotti, Lawrence
Preston-Thomas, Annie 
Rubenach, Sally 
O'Sullivan, Siobhan 
Allen, Darren
Ragh, Thomas 
Grayson, Sachjuan 
Manoy, Sophie 
Warner, Jeffery M
Meumann, Ella M
Robson, Jennifer M
Hanson, Josh 
Issue Date: 2023
Source: Smith S, Marquardt T, Jennison AV, D'Addona A, Stewart J, Yarwood T, Ho J, Binotto E, Harris J, Fahmy M, Esmonde J, Richardson M, Graham RMA, Gair R, Ariotti L, Preston-Thomas A, Rubenach S, O'Sullivan S, Allen D, Ragh T, Grayson S, Manoy S, Warner JM, Meumann EM, Robson JM, Hanson J. Clinical Manifestations and Genomic Evaluation of Melioidosis Outbreak among Children after Sporting Event, Australia. Emerg Infect Dis. 2023 Nov;29(11):2218-2228. doi: 10.3201/eid2911.230951. PMID: 37877500; PMCID: PMC10617349.
Journal: Emerging infectious diseases
Abstract: Melioidosis, caused by the environmental gram-negative bacterium Burkholderia pseudomallei, usually develops in adults with predisposing conditions and in Australia more commonly occurs during the monsoonal wet season. We report an outbreak of 7 cases of melioidosis in immunocompetent children in Australia. All the children had participated in a single-day sporting event during the dry season in a tropical region of Australia, and all had limited cutaneous disease. All case-patients had an adverse reaction to oral trimethoprim/sulfamethoxazole treatment, necessitating its discontinuation. We describe the clinical features, environmental sampling, genomic epidemiologic investigation, and public health response to the outbreak. Management of this outbreak shows the potential benefits of making melioidosis a notifiable disease. The approach used could also be used as a framework for similar outbreaks in the future.
Description: Cairns & Hinterland Hospital and Health Service (CHHHS) affiliated authors: Simon Smith, Tonia Marquardt, Andrew D’Addona, James Stewart, Trent Yarwood, Jennifer Ho, Enzo Binotto, Julian Harris, Mark Fahmy, Juliet Esmonde, Megan Richardson, Richard Gair, Annie Preston-Thomas, Sally Rubenach, Siobhan O’Sullivan, Thomas Ragh, Sachjuan Grayson, Sophie Manoy, Josh Hanson
DOI: 10.3201/eid2911.230951
Keywords: Australia;Burkholderia pseudomallei;bacteria;melioidosis;pediatrics;public health;tropical medicine
Type: Article
Appears in Sites:Cairns & Hinterland HHS Publications

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