Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/5347
Title: The epidemiology and clinical features of rickettsial diseases in North Queensland, Australia: Implications for patient identification and management
Authors: Stewart, Alexandra G A
Smith, Simon 
Binotto, Enzo 
McBride, William J H
Hanson, Josh 
Issue Date: 2019
Source: Stewart AGA, Smith S, Binotto E, McBride WJH, Hanson J (2019) The epidemiology and clinical features of rickettsial diseases in North Queensland, Australia: Implications for patient identification and management. PLOS Neglected Tropical Diseases 13(7): e0007583. https://doi.org/10.1371/journal.pntd.0007583
Journal: PLoS neglected tropical diseases
Abstract: Background Rickettsial infections are a common cause of hospitalization in tropical settings, although early diagnosis is challenging in the rural locations where these infections are usually seen. Methods This retrospective, clinical audit of microbiologically-confirmed cases of scrub typhus or spotted fever group (SFG) rickettsial infection between 1997 and 2016 was performed a tertiary referral hospital in tropical Australia. Clinical, laboratory and radiological findings at presentation were correlated with the patients’ subsequent clinical course. Results There were 135 locally-acquired cases (95 scrub typhus, 37 SFG, 3 undifferentiated). There were nine hospitalizations during the first 5 years of the study period and 81 in the last 5 years (p for trend = 0.003). Eighteen (13%) of the 135 cases required ICU admission, all of whom were adults. A greater proportion of patients with SFG infection required ICU support (8/37 (22%) compared with 10/95 (11%) scrub typhus cases), although this difference did not reach statistical significance (p = 0.10). Three (8%) of the 37 patients with SFG infection had severe disease (1 died, 2 developed permanent disability) versus 0/95 scrub typhus patients (p = 0.02). Adults with a high admission qSOFA score (≥2) had an odds ratio (OR) of 19 (95% CI:4.8–74.5) for subsequent ICU admission (p<0.001); adults with a high NEWS2 score (≥7) had an OR of 14.3 (95% CI:4.5–45.32) for ICU admission (p<0.001). A patient’s respiratory rate at presentation had strong prognostic utility: if an adult had an admission respiratory rate <22 breaths/minute, the negative predictive value for subsequent ICU admission was 95% (95% CI 88–99). Conclusions In the well-resourced Australian health system outcomes are excellent, but the local burden of rickettsial disease appears to be increasing and the clinical phenotype of SFG infections may be more severe than previously believed. Simple, clinical assessment on admission has prognostic utility and may be used to guide management.
Description: Cairns & Hinterland Hospital and Health Service (CHHHS) affiliated authors: Alexandra G. A. Stewart, Simon Smith, Enzo Binotto, Josh Hanson
DOI: 10.1371/journal.pntd.0007583
Keywords: Scrub typhus;Intensive care units;Respiratory infections;Australia;Fevers;Serodiagnosis;Serology;Medical risk factors
Type: Article
Appears in Sites:Cairns & Hinterland HHS Publications

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