Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/5331
Title: Dementia Risk Models in an Australian First Nations Population: Cross-Sectional Associations and Preparation for Follow-Up
Authors: Thompson, Fintan 
Russell, Sarah 
Quigley, Rachel 
Sagigi, Betty
Miller, Gavin 
Esterman, Adrian
Harriss, Linton 
Taylor, Sean
McDermott, Robyn
Strivens, Edward 
Issue Date: 2023
Source: Thompson F, Russell S, Quigley R, Sagigi B, Miller G, Esterman A, Harriss LR, Taylor S, McDermott R, Strivens E. Dementia Risk Models in an Australian First Nations Population: Cross-Sectional Associations and Preparation for Follow-Up. J Alzheimers Dis Rep. 2023 Jun 5;7(1):543-555. doi: 10.3233/ADR-220093. PMID: 37313487; PMCID: PMC10259055.
Journal: Journal of Alzheimer's disease reports
Abstract: Background: Reducing the burden of dementia in First Nations populations may be addressed through developing population specific methods to quantify future risk of dementia. Objective: To adapt existing dementia risk models to cross-sectional dementia prevalence data from a First Nations population in the Torres Strait region of Australia in preparation for follow-up of participants. To explore the diagnostic utility of these dementia risk models at detecting dementia. Methods: A literature review to identify existing externally validated dementia risk models. Adapting these models to cross-sectional data and assessing their diagnostic utility through area under the receiver operating characteristic curve (AUROC) analyses and calibration using Hosmer-Lemeshow Chi2. Results: Seven risk models could be adapted to the study data. The Aging, Cognition and Dementia (AgeCoDe) study, the Framingham Heart Study (FHS), and the Brief Dementia Screening Indicator (BDSI) had moderate diagnostic utility in identifying dementia (i.e., AUROC >0.70) before and after points for older age were removed. Conclusion: Seven existing dementia risk models could be adapted to this First Nations population, and three had some cross-sectional diagnostic utility. These models were designed to predict dementia incidence, so their applicability to identify prevalent cases would be limited. The risk scores derived in this study may have prognostic utility as participants are followed up over time. In the interim, this study highlights considerations when transporting and developing dementia risk models for First Nations populations.
Description: Cairns & Hinterland Hospital and Health Service (CHHHS) affiliated authors: Fintan Thompson, Sarah Russell, Rachel Quigley, Gavin Miller, Linton R Harriss, Edward Strivens
DOI: 10.3233/ADR-220093
Keywords: Alzheimer’s disease;Australia;First Nations;Indigenous;dementia;diagnostic;risk models
Type: Article
Appears in Sites:Cairns & Hinterland HHS Publications
Torres & Cape HHS Publications

Files in This Item:
File Description SizeFormat 
Dementia risk models in an Australian First Nations population.pdf327.29 kBAdobe PDFThumbnail
View/Open
Show full item record

Page view(s)

198
checked on Dec 24, 2024

Download(s)

82
checked on Dec 24, 2024

Google ScholarTM

Check

Altmetric


Items in DORA are protected by copyright, with all rights reserved, unless otherwise indicated.