Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/96
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dc.contributor.authorScaria, A.en
dc.contributor.authorCass, A.en
dc.contributor.authorZhang, L.en
dc.contributor.authorde Zoysa, J.en
dc.contributor.authorMorrish, A. T.en
dc.contributor.authorVergara, L. A.en
dc.contributor.authorPascoe, E. M.en
dc.contributor.authorClark, C.en
dc.contributor.authorLiu, X.en
dc.contributor.authorMcTaggart, S.en
dc.contributor.authorJohnson, D. W.en
dc.contributor.authorIsbel, N. M.en
dc.contributor.authorSnelling, P.en
dc.contributor.authorHawley, C. M.en
dc.contributor.authorBadve, S. V.en
dc.contributor.authorPlayford, G.en
dc.contributor.authorBeller, E.en
dc.date.accessioned2018-06-16T20:29:32Z-
dc.date.available2018-06-16T20:29:32Z-
dc.date.issued2017en
dc.identifier.citation37, (5), 2017, p. 516-522en
dc.identifier.otherRISen
dc.identifier.urihttp://dora.health.qld.gov.au/qldresearchjspui/handle/1/96-
dc.description.abstract♦ Background: The HONEYPOT trial failed to establish the superiority of exit-site application of Medihoney compared with nasal mupirocin prophylaxis for the prevention of peritonitis in peritoneal dialysis (PD) patients. This study aimed to assess the representativeness of the patients in the HONEYPOT trial to the Australian and New Zealand PD population. ♦ Methods: This study compared baseline characteristics of the 371 PD patients in the HONEYPOT trial with those of 6,085 PD patients recorded on the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry. ♦ Results: Compared with the PD population, the HONEYPOT sample was older (standardized difference [d] = 0.19, p = 0.003), more likely to be treated with automated PD (d = 0.58, p < 0.001), had higher residual renal function (d = 0.26, p < 0.001) and a higher proportion of participants with end-stage kidney disease due to polycystic kidney disease (d = 0.17) and lower proportion due to diabetes (d = -0.17) and glomerulonephritis (d = -0.18) (p < 0.001), and lower proportions of indigenous people (d = -0.17, p < 0.001), current smokers (d = -0.10, p < 0.001), and people with prior histories of hemodialysis (d = -0.16, p < 0.001), diabetes mellitus (d = -0.18, p < 0.001), and coronary artery disease (d = -0.15, p < 0.001). ♦ Conclusions: HONEYPOT trial participants tended to be healthier than the Australian and New Zealand PD patient population. Although the differences between the groups were generally modest, it is possible that their cumulative effect may have had some impact on external generalizability, which is not an uncommon occurrence in clinical trials.L618450498 <br />en
dc.languageenen
dc.relation.ispartofPeritoneal Dialysis Internationalen
dc.titleRepresentativeness of honeypot trial participants to Australasian PD patientsen
dc.typeArticleen
dc.identifier.doi10.3747/pdi.2016.00065en
dc.subject.keywordsadultAustralia and New Zealanden
dc.subject.keywordsclinical trialen
dc.subject.keywordscontrolled clinical trialen
dc.subject.keywordscontrolled studyen
dc.subject.keywordscoronary artery diseaseen
dc.subject.keywordsdiabetes mellitusen
dc.subject.keywordsdrug therapyen
dc.subject.keywordsend stage renal diseaseen
dc.subject.keywordsfemaleen
dc.subject.keywordsglomerulonephritisen
dc.subject.keywordshemodialysisen
dc.subject.keywordshoneyen
dc.subject.keywordshumanen
dc.subject.keywordsindigenous peopleen
dc.subject.keywordskidney functionen
dc.subject.keywordskidney polycystic diseaseen
dc.subject.keywordsmajor clinical studyen
dc.subject.keywordsmaleen
dc.subject.keywordsperitoneal dialysisen
dc.subject.keywordsperitonitisen
dc.subject.keywordsregisteren
dc.subject.keywordssmokingen
dc.subject.keywordspseudomonic aciden
dc.relation.url/search/results?subaction=viewrecord&from=export&id=L618450498http://dx.doi.org/10.3747/pdi.2016.00065en
dc.identifier.risid1112en
dc.description.pages516-522en
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.grantfulltextnone-
item.fulltextNo Fulltext-
Appears in Sites:Sunshine Coast HHS Publications
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