FLT3-ITD positive acute myeloid leukemia: A retrospective analysis of the role of allogeneic transplant and allelic ratio in patient management

Abstract

AIM: FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) positive AML is associated with increased relapse risk and reduced overall survival (OS) compared to non-FLT3-mutated AML. The aim of this study was to evaluate the impact of allelic ratio and allogeneic transplant on outcomes in FLT3-ITD+ AML. METHODS: A retrospective study across five centers in Queensland, Australia, was conducted to examine survival outcomes and impact of FLT3-ITD allelic ratio and allograft. RESULTS: Seventy-one patients were included in the study. OS was significantly better for patients who were able to be allografted in first complete remission (CR1; 50.1 months vs 8.5 months; P = 0.0002). We did not find allelic ratio to be predictive of outcome. CONCLUSION: Transplantation in first complete remission is associated with improved outcomes for patients with FLT3+ AML. When feasible transplantation in CR1 is recommended. We do not currently recommend using allelic ratio to stratify risk unless this has been validated by local results.1743-7563Taylor, Emma <br />ORCID: http://orcid.org/0000-0001-9308-9339 <br />Morris, Kirk <br />Ellis, Marc <br />Marlton, Paula <br />Baveshi, Ketan <br />Clarey, Joseph <br />Irving, Ian <br />Cochrane, Tara <br />Kennedy, Glen <br />Journal Article <br />Australia <br />Asia Pac J Clin Oncol. 2018 Jan 31. doi: 10.1111/ajco.12827. <br />