60. An antimicrobial dressing for prevention of infection complication related peripheral intravenous catheter: an international randomised controlled trial

Abstract

Introduction: Although Peripheral intravenous catheters (PIVCs) are prevalent in hospitalised patients, they may be complicated by infectious complications leading to morbidity, mortality and increased costs. Our aim was to evaluate chlorhexidine gluconate (CHG)-impregnated dressings for prevention of PIVC related infectious complications. Methods: A multicentre, randomised controlled cost-effectiveness trial with internal pilot, across three centres in Australia and France. Adults and children aged ≥6 years requiring one PIVC for ≥48 hours were eligible. Patients were randomised to antimicrobial dressings or standard polyurethane dressings. The internal pilot objective was to test protocol feasibility without review of clinical outcomes. Following feasibility assessment, the full trial may be conducted following the same methods. The full trial primary endpoint is a composite of catheter-related infectious complications and phlebitis, since phlebitis may indicate early infection. Ethics approval was obtained and the trial registered (ClinicalTrials.gov NCT05741866). Results: 300 patients (100 France; 200 Australia) were recruited between May 3rd, 2023 and March 27th,2024 for internal pilot and […] were assigned to antimicrobial dressings group and […] to standard care group. The results of the feasibility study are being analysed at the time of submission of the abstract and will be available at the time of the congress. Conclusion: Prop Trial is the first international randomised study to evaluate the safety, efficacy and cost-effectiveness of an antimicrobial PIVC dressing.