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DC Field | Value | Language |
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dc.contributor.author | Georgia D. Bennett | en |
dc.contributor.author | Krysti Rosmalen-Brinkley | en |
dc.contributor.author | Johnstone, Kristoffer | en |
dc.contributor.author | Messina, Genevieve | en |
dc.date.accessioned | 2024-10-29T02:17:24Z | - |
dc.date.available | 2024-10-29T02:17:24Z | - |
dc.date.issued | 2024 | - |
dc.identifier.citation | Bennett, G.D., Rosmalen-Brinkley, K., Johnstone, K. and Messina, G. (2024), Two instances of successful oral desensitisation following hypersensitivity reaction in a patient receiving osimertinib: a case report. J Pharm Pract Res, 54: 328-332. https://doi.org/10.1002/jppr.1928 | en |
dc.identifier.uri | https://dora.health.qld.gov.au/qldresearchjspui/handle/1/6521 | - |
dc.description | Cairns & Hinterland Hospital and Health Service (CHHHS) affiliated authors: Georgia D. Bennett, Krysti Rosmalen-Brinkley, Kristoffer Johnstone, Genevieve Messina | en |
dc.description.abstract | Background Osimertinib is an irreversible epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitor (TKI) and an available therapy for patients with non-small cell lung cancer (NSCLC) that have an EGFR or T790M mutation. It has become the preferred TKI in this patient group as it is superior to first-generation TKIs; however, osimertinib may be discontinued due to various toxicities or reactions. Aim We report two instances of successful osimertinib desensitisation in a 70-year-old woman requiring treatment for NSCLC following two hypersensitivity reactions presenting as angioedema and urticaria. Clinical details Osimertinib desensitisation started at 5 mg/day and was gradually increased to 80 mg/day over a period of 30 days. Outcomes The patient continued osimertinib 80 mg daily for over a year until treatment was withheld for 4 weeks due to thrombocytopenia and diverticulitis. She restarted osimertinib, completing a second desensitisation to a reduced dose of 40 mg daily without serious adverse effect. The patient continues reduced-dose osimertinib with stable disease. Conclusion This case report proposes an osimertinib desensitisation strategy useful for select patients experiencing osimertinib-induced hypersensitivity reactions. It also demonstrates that if there is prolonged disruption to treatment, a second desensitisation can be completed successfully in the same patient so effective treatment in NSCLC may be continued. | en |
dc.language.iso | en | en |
dc.publisher | Society of Hospital Pharmacists of Australia | en |
dc.relation.ispartof | Journal of Pharmacy Practice & Research | en |
dc.subject | osimertinib | en |
dc.subject | hypersensitivity | en |
dc.subject | desensitisation | en |
dc.subject | non-small cell lung cancer (NSCLC) | en |
dc.subject | epidermal growth factor receptor (EGFR) | en |
dc.subject | case report | en |
dc.title | Two instances of successful oral desensitisation following hypersensitivity reaction in a patient receiving osimertinib: a case report | en |
dc.type | Article | en |
dc.identifier.doi | 10.1002/jppr.1928 | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairetype | Article | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Sites: | Cairns & Hinterland HHS Publications |
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File | Description | Size | Format | |
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Two instances of successful oral desensitisation following hypersensitivity reaction.pdf | 929.28 kB | Adobe PDF | View/Open |
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