Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/6521
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dc.contributor.authorGeorgia D. Bennetten
dc.contributor.authorKrysti Rosmalen-Brinkleyen
dc.contributor.authorJohnstone, Kristofferen
dc.contributor.authorMessina, Genevieveen
dc.date.accessioned2024-10-29T02:17:24Z-
dc.date.available2024-10-29T02:17:24Z-
dc.date.issued2024-
dc.identifier.citationBennett, G.D., Rosmalen-Brinkley, K., Johnstone, K. and Messina, G. (2024), Two instances of successful oral desensitisation following hypersensitivity reaction in a patient receiving osimertinib: a case report. J Pharm Pract Res, 54: 328-332. https://doi.org/10.1002/jppr.1928en
dc.identifier.urihttps://dora.health.qld.gov.au/qldresearchjspui/handle/1/6521-
dc.descriptionCairns & Hinterland Hospital and Health Service (CHHHS) affiliated authors: Georgia D. Bennett, Krysti Rosmalen-Brinkley, Kristoffer Johnstone, Genevieve Messinaen
dc.description.abstractBackground Osimertinib is an irreversible epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitor (TKI) and an available therapy for patients with non-small cell lung cancer (NSCLC) that have an EGFR or T790M mutation. It has become the preferred TKI in this patient group as it is superior to first-generation TKIs; however, osimertinib may be discontinued due to various toxicities or reactions. Aim We report two instances of successful osimertinib desensitisation in a 70-year-old woman requiring treatment for NSCLC following two hypersensitivity reactions presenting as angioedema and urticaria. Clinical details Osimertinib desensitisation started at 5 mg/day and was gradually increased to 80 mg/day over a period of 30 days. Outcomes The patient continued osimertinib 80 mg daily for over a year until treatment was withheld for 4 weeks due to thrombocytopenia and diverticulitis. She restarted osimertinib, completing a second desensitisation to a reduced dose of 40 mg daily without serious adverse effect. The patient continues reduced-dose osimertinib with stable disease. Conclusion This case report proposes an osimertinib desensitisation strategy useful for select patients experiencing osimertinib-induced hypersensitivity reactions. It also demonstrates that if there is prolonged disruption to treatment, a second desensitisation can be completed successfully in the same patient so effective treatment in NSCLC may be continued.en
dc.language.isoenen
dc.publisherSociety of Hospital Pharmacists of Australiaen
dc.relation.ispartofJournal of Pharmacy Practice & Researchen
dc.subjectosimertiniben
dc.subjecthypersensitivityen
dc.subjectdesensitisationen
dc.subjectnon-small cell lung cancer (NSCLC)en
dc.subjectepidermal growth factor receptor (EGFR)en
dc.subjectcase reporten
dc.titleTwo instances of successful oral desensitisation following hypersensitivity reaction in a patient receiving osimertinib: a case reporten
dc.typeArticleen
dc.identifier.doi10.1002/jppr.1928-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Sites:Cairns & Hinterland HHS Publications
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