Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/6221
Title: Genetics in relation to cardiac diseases: Implications for general practitioners
Authors: Ng, Kevin 
Rahman, Atifur 
Issue Date: 2024
Publisher: Royal Australian College of General Practitioners
Source: Ng K, Rahman A. Genetics in relation to cardiac diseases: Implications for general practitioners. Aust J Gen Pract. 2024 Jul;53(7):463-470. doi: 10.31128/AJGP-10-23-6986. PMID: 38957060.
Journal Title: Australian journal of general practice
Journal: Australian Journal of General Practice
Abstract: Cardiovascular diseases (CVDs) pose significant global health challenges, with genetics increasingly recognised as a key factor alongside traditional risk factors. This presents an opportunity for general practitioners (GPs) to refine their approaches. This article explores the impact of genetics on CVDs and its implications for GPs. It discusses monogenic disorders like inherited cardiomyopathies and polygenic risks, as well as pharmacogenetics, aiming to enhance risk assessment and personalised care. Monogenic disorders, driven by single gene mutations, exhibit predictable inheritance patterns, including inherited cardiomyopathies and channelopathies such as Long QT syndrome. Polygenic risks involve multiple genetic variants influencing CVD susceptibility, addressed through polygenic risk scores for precise risk assessment. Pharmacogenetics tailor drug interventions based on genetic profiles, though challenges like accessibility and ethical considerations persist. Integrating genetics into cardiovascular care holds promise for alleviating the global CVD burden and improving patient outcomes.
Description: Cairns & Hinterland Hospital and Health Service (CHHHS) affiliated author: Kevin Ng
DOI: 10.31128/AJGP-10-23-6986
Type: Article
Appears in Sites:Cairns & Hinterland HHS Publications

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