Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/557
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dc.contributor.authorSilverberg, M. S.en
dc.contributor.authorBefrits, R.en
dc.contributor.authorSchreiber, S.en
dc.contributor.authorD'Haens, G.en
dc.contributor.authorOchsenkuhn, T.en
dc.contributor.authorReinisch, W.en
dc.contributor.authorvan der Woude, C. J.en
dc.contributor.authorMichetti, P.en
dc.contributor.authorSorrentino, D.en
dc.contributor.authorConnell, W.en
dc.contributor.authorVan Assche, G.en
dc.contributor.authorPanaccione, R.en
dc.contributor.authorPanes, J.en
dc.contributor.authorVermeire, S.en
dc.contributor.authorGhosh, S.en
dc.date.accessioned2018-06-16T20:35:31Z-
dc.date.available2018-06-16T20:35:31Z-
dc.date.issued2012en
dc.identifier.citationMarch 6 (2) , 2012, p. 248-258en
dc.identifier.otherRISen
dc.identifier.urihttp://dora.health.qld.gov.au/qldresearchjspui/handle/1/557-
dc.description.abstractBackground and aims: Infliximab is currently the only biologic approved for treatment of adults with moderate to severe, active ulcerative colitis (UC) unresponsive to conventional therapies. It rapidly controls symptoms, induces and sustains steroid-free remission, stimulates mucosal healing, and reduces serious complications. Although infliximab tends to be reserved for patients with severe disease, it may be even more beneficial for moderate disease earlier in the disease course. Therefore, it is important to identify which patients are candidates for infliximab therapy. Methods: A collaborative Delphi survey was used to obtain consensus on use of biologic therapy in patients with UC from an expert panel of 12 gastroenterologists with substantial experience using infliximab in clinical practice and clinical trials. The panel also addressed issues that influence the use of infliximab in UC, including its potential as an alternative to surgery. Results: The panel agreed that: (1) it is necessary to adopt additional treatment goals beyond symptom control, i.e., complete mucosal healing, steroid-free remission, improved QoL, and reduced long-term complications; (2) it may be possible to achieve these treatment goals with infliximab, especially if it is used earlier in the course of UC; and (3) infliximab should be offered as an alternative to surgery in patients being considered for colectomy. The panel also agreed on factors for identifying candidates for infliximab therapy (e.g., persistently active UC, steroid-dependent/refractory disease, and high C-reactive protein). Conclusions: This consensus statement provides useful and practical information on how to achieve evolving treatment goals with infliximab in moderate to severe UC. 2011.<br />en
dc.languageenen
dc.relation.ispartofJournal of Crohn's and Colitisen
dc.titleRecommendations for the treatment of ulcerative colitis with infliximab: A gastroenterology expert group consensusen
dc.typeArticleen
dc.relation.urlhttp://getit.slq.qld.gov.au/qhealth?sid=OVID:embase&id=pmid:&id=doi:10.1016%2Fj.crohns.2011.11.001&issn=1873-9946&isbn=&volume=6&issue=2&spage=248&pages=248-258&date=2012&title=Journal+of+Crohn%27s+and+Colitis&atitle=Recommendations+for+the+treatment+of+ulcerative+colitis+with+infliximab%3A+A+gastroenterology+expert+group+consensus&aulast=Reinisch&pid=%3Cauthor%3EReinisch+W.%3BVan+Assche+G.%3BBefrits+R.%3BConnell+W.%3BD%27Haens+G.%3BGhosh+S.%3BMichetti+P.%3BOchsenkuhn+T.%3BPanaccione+R.%3BSchreiber+S.%3BSilverberg+M.S.%3BSorrentino+D.%3Bvan+der+Woude+C.J.%3BVermeire+S.%3BPanes+J.%3C%2Fauthor%3E%3CAN%3E2012082078%3C%2FAN%3E%3CDT%3EJournal%3A+Review%3C%2FDT%3Een
dc.identifier.risid418en
dc.description.pages248-258en
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.grantfulltextnone-
item.fulltextNo Fulltext-
Appears in Sites:Queensland Health Publications
Sunshine Coast HHS Publications
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