Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/5433
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKing, Shannon Jen
dc.contributor.authorReid, Natashaen
dc.contributor.authorBrown, Sarah Jen
dc.contributor.authorBrodie, Lucinda Jen
dc.contributor.authorSia, Aaron D Hen
dc.contributor.authorChatfield, Mark Den
dc.contributor.authorFrancis, Rossen
dc.contributor.authorPeel, Nancye Men
dc.contributor.authorGordon, Emily Hen
dc.contributor.authorHubbard, Ruth Een
dc.date.accessioned2023-11-23T02:08:09Z-
dc.date.available2023-11-23T02:08:09Z-
dc.date.issued2023-
dc.identifier.citationKing, S.J., Reid, N., Brown, S.J. et al. A prospective, observational study of frailty, quality of life and dialysis in older people with advanced chronic kidney disease. BMC Geriatr 23, 664 (2023). https://doi.org/10.1186/s12877-023-04365-4en
dc.identifier.urihttps://dora.health.qld.gov.au/qldresearchjspui/handle/1/5433-
dc.descriptionCairns & Hinterland Hospital and Health Service (CHHHS) affiliated author: Sarah J Brownen
dc.description.abstractFrailty is prevalent in older people with chronic kidney disease (CKD) and robust evidence supporting the benefit of dialysis in this setting is lacking. We aimed to measure frailty and quality of life (QOL) longitudinally in older people with advanced CKD and assess the impact of dialysis initiation on frailty, QOL and mortality. Outpatients aged ≥65 with an eGFR ≤ 20ml/minute/1.73m2 were enrolled in a prospective observational study and followed up four years later. Frailty status was measured using a Frailty Index (FI), and QOL was evaluated using the EuroQol 5D-5L instrument. Mortality and dialysis status were determined through inspection of electronic records. Ninety-eight participants were enrolled. Between enrolment and follow-up, 36% of participants commenced dialysis and 59% died. Frailty prevalence increased from 47% at baseline to 86% at follow-up (change in median FI = 0.22, p < 0.001). Initiating dialysis was not significantly associated with change in FI. QOL declined from baseline to follow-up (mean EQ-5D-5L visual analogue score of 70 vs 63, p = 0.034), though commencing dialysis was associated with less decline in QOL. Each 0.1 increment in baseline FI was associated with 59% increased mortality hazard (HR = 1.59, 95%CI = 1.20 to 2.12, p = 0.001), and commencing dialysis was associated with 59% reduction in mortality hazard (HR = 0.41, 95%CI = 0.20 to 0.87, p = 0.020) irrespective of baseline FI. Frailty increased substantially over four years, and higher baseline frailty was associated with greater mortality. Commencing dialysis did not affect the trajectory of FI but positively influenced the trajectory of QOL from baseline to follow-up. Within the limitations of small sample size, our data suggests that frail participants received similar survival benefit from dialysis as non-frail participants.en
dc.language.isoenen
dc.relation.ispartofBMC geriatricsen
dc.subjectRenal insufficiency, chronicen
dc.subjectRenal dialysisen
dc.subjectFrailtyen
dc.subjectMortalityen
dc.subjectQuality of lifeen
dc.titleA prospective, observational study of frailty, quality of life and dialysis in older people with advanced chronic kidney diseaseen
dc.typeArticleen
dc.identifier.doi10.1186/s12877-023-04365-4-
dc.identifier.pmid37845618-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairetypeArticle-
Appears in Sites:Cairns & Hinterland HHS Publications
Show simple item record

Page view(s)

98
checked on Dec 23, 2024

Download(s)

86
checked on Dec 23, 2024

Google ScholarTM

Check

Altmetric


Items in DORA are protected by copyright, with all rights reserved, unless otherwise indicated.