Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/5401
Title: COVID-19 infection among patients with cancer in Australia from 2020 to 2022: a national multicentre cohort study
Authors: Hall, Victoria G
Sim, Beatrice Z
Lim, Chhay
Hocking, Christopher
Teo, Teddy
Runnegar, Naomi 
Boan, Peter
Heath, Christopher H
Rainey, Natalie 
Lyle, Megan 
Steer, Christopher
Liu, Eunice
Doig, Cassandra
Drummond, Kate
Charles, Patrick G P
See, Katharine
Lim, Lyn-Li
Shum, Omar
Bak, Narin
Mclachlan, Sue-Anne
Singh, Kasha P
Laundy, Nicholas
Gallagher, Jenny
Stewart, Marcelle
Saunders, Natalie R
Klimevski, Emily
Demajo, Jessica
Reynolds, Gemma
Thursky, Karin A
Worth, Leon J
Spelman, Timothy
Yong, Michelle K
Slavin, Monica A
Teh, Benjamin W
Issue Date: 2023
Source: Hall VG, Sim BZ, Lim C, Hocking C, Teo T, Runnegar N, Boan P, Heath CH, Rainey N, Lyle M, Steer C, Liu E, Doig C, Drummond K, Charles PGP, See K, Lim LL, Shum O, Bak N, Mclachlan SA, Singh KP, Laundy N, Gallagher J, Stewart M, Saunders NR, Klimevski E, Demajo J, Reynolds G, Thursky KA, Worth LJ, Spelman T, Yong MK, Slavin MA, Teh BW. COVID-19 infection among patients with cancer in Australia from 2020 to 2022: a national multicentre cohort study. Lancet Reg Health West Pac. 2023 Jun 19;38:100824. doi: 10.1016/j.lanwpc.2023.100824. Epub ahead of print. PMID: 37360862; PMCID: PMC10278158.
Journal: The Lancet regional health. Western Pacific
Abstract: The global COVID-19 pandemic disproportionately affected certain populations and its management differed between countries. This national study describes characteristics and outcomes of COVID-19 in patients with cancer in Australia. We performed a multicentre cohort study of patients with cancer and COVID-19 from March 2020 to April 2022. Data were analysed to determine varying characteristics between cancer types and changes in outcomes over time. Multivariable analysis was performed to determine risk factors associated with oxygen requirement. 620 patients with cancer from 15 hospitals had confirmed COVID-19. There were 314/620 (50.6%) male patients, median age 63.5 years (IQR 50-72) and majority had solid organ tumours (392/620, 63.2%). The rate of COVID-19 vaccination (≥1 dose) was 73.4% (455/620). Time from symptom onset to diagnosis was median 1 day (IQR 0-3), patients with haematological malignancy had a longer duration of test positivity. Over the study period, there was a significant decline in COVID-19 severity. Risk factors associated with oxygen requirement included male sex (OR 2.34, 95% CI 1.30-4.20, p = 0.004), age (OR 1.03, 95% CI 1.01-1.06, p = 0.005); not receiving early outpatient therapy (OR 2.78, 95% CI 1.41-5.50, p = 0.003). Diagnosis during the omicron wave was associated with lower odds of oxygen requirement (OR 0.24, 95% CI 0.13-0.43, p < 0.0001). Outcomes from COVID-19 in patients with cancer in Australia over the pandemic have improved, potentially related to changing viral strain and outpatient therapies. This study was supported by research funding from MSD.
Description: Cairns & Hinterland Hospital and Health Service (CHHHS) affiliated authors: Natalie Rainey, Megan Lyle
DOI: 10.1016/j.lanwpc.2023.100824
Keywords: COVID-19;Severity;Vaccination;Treatment
Type: Article
Appears in Sites:Cairns & Hinterland HHS Publications

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