Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/5383
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dc.contributor.authorEkinci, Elif Ien
dc.contributor.authorBarr, Elizabeth L Men
dc.contributor.authorBarzi, Federicaen
dc.contributor.authorHughes, Jaquelyne Ten
dc.contributor.authorLawton, Paul Den
dc.contributor.authorJones, Graham R Den
dc.contributor.authorHoy, Wendyen
dc.contributor.authorCass, Alanen
dc.contributor.authorThomas, Marken
dc.contributor.authorSinha, Ashimen
dc.contributor.authorJerums, Georgeen
dc.contributor.authorO'Dea, Kerinen
dc.contributor.authorMacIsaac, Richard Jen
dc.contributor.authorMaple-Brown, Louise Jen
dc.date.accessioned2023-10-09T04:37:02Z-
dc.date.available2023-10-09T04:37:02Z-
dc.date.issued2019-
dc.identifier.citationEkinci EI, Barr ELM, Barzi F, Hughes JT, Lawton PD, Jones GRD, Hoy W, Cass A, Thomas M, Sinha A, Jerums G, O'Dea K, MacIsaac RJ, Maple-Brown LJ. Is hyperfiltration associated with higher urine albumin-to-creatinine ratio at follow up among Indigenous Australians? The eGFR follow-up study. J Diabetes Complications. 2019 May;33(5):343-349. doi: 10.1016/j.jdiacomp.2019.02.005. Epub 2019 Feb 21. PMID: 30904420.en
dc.identifier.urihttps://dora.health.qld.gov.au/qldresearchjspui/handle/1/5383-
dc.descriptionCairns & Hinterland Hospital and Health Service (CHHHS) affiliated author: Ashim Sinhaen
dc.description.abstractGlomerular hyperfiltration is not able to be detected in clinical practice. We assessed whether hyperfiltration is associated with albuminuria progression among Indigenous Australians at high risk of diabetes and kidney disease to determine its role in kidney disease progression. Longitudinal observational study of Indigenous Australians aged ≥18 years recruited from >20 sites, across diabetes and/or kidney function strata. At baseline, iohexol clearance was used to measure glomerular filtration rate (mGFR) and hyperfiltration was defined as (i) a mGFR of ≥125 mL/min/1.73 m2, and (ii) an age-adjusted definition, with the top 10% of the mGFR for each 10 year age group at baseline. Baseline and follow-up urine albumin-to-creatinine ratio (uACR) was collected, and linear regression was used to assess the associations of hyperfiltration and uACR at follow up. 407 individuals (33% men, mean age 47 years) were followed-up for a median of 3 years. At baseline, 234 had normoalbuminuria and 173 had albuminuria. Among participants with normoalbuminuria, those with mGFR ≥125 mL/min/1.73 m2 had 32% higher uACR at follow-up (p = 0.08), and those with age-adjusted hyperfiltration had 60% higher uACR (p = 0.037) compared to those who had normofiltration. These associations were independent of uACR at baseline, but attenuated by HbA1c. Associations were stronger among those without than those with albuminuria at baseline. Although not available for assessment in current clinical practice, hyperfiltration may represent a marker of subsequent albuminuria progression among individuals who have not yet developed albuminuria.en
dc.language.isoenen
dc.relation.ispartofJournal of diabetes and its complicationsen
dc.subjectAlbuminuriaen
dc.subjectChronic kidney diseaseen
dc.subjectDiabetic kidney diseaseen
dc.subjectDiabetic nephropathyen
dc.subjectHyperfiltrationen
dc.subjectIndigenous Australiansen
dc.titleIs hyperfiltration associated with higher urine albumin-to-creatinine ratio at follow up among Indigenous Australians? The eGFR follow-up studyen
dc.typeArticleen
dc.identifier.doi10.1016/j.jdiacomp.2019.02.005-
dc.identifier.pmid30904420-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairetypeArticle-
Appears in Sites:Cairns & Hinterland HHS Publications
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