Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/5172
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dc.contributor.authorLittle, Marken
dc.contributor.authorPereira, Peteren
dc.contributor.authorSeymour, Jamieen
dc.date.accessioned2023-06-08T04:24:55Z-
dc.date.available2023-06-08T04:24:55Z-
dc.date.issued2020-
dc.identifier.citationLittle, M., Pereira, P., & Seymour, J. (2020). Differences in Cardiac Effects of Venoms from Tentacles and the Bell of Live Carukia barnesi: Using Non-Invasive Pulse Wave Doppler. Toxins, 13(1), 19. https://doi.org/10.3390/toxins13010019en
dc.identifier.urihttps://dora.health.qld.gov.au/qldresearchjspui/handle/1/5172-
dc.descriptionCairns & Hinterland Hospital and Health Service (CHHHS) affiliated authors: Mark Little, Peter Pereiraen
dc.description.abstractCarukia barnesi was the first in an expanding list of cubozoan jellyfish whose sting was identified as causing Irukandji syndrome. Nematocysts present on both the bell and tentacles are known to produce localised stings, though their individual roles in Irukandji syndrome have remained speculative. This research examines differences through venom profiling and pulse wave Doppler in a murine model. The latter demonstrates marked measurable differences in cardiac parameters. The venom from tentacles (CBVt) resulted in cardiac decompensation and death in all mice at a mean of 40 min (95% CL: ± 11 min), whereas the venom from the bell (CBVb) did not produce any cardiac dysfunction nor death in mice at 60 min post-exposure. This difference is pronounced, and we propose that bell exposure is unlikely to be causative in severe Irukandji syndrome. To date, all previously published cubozoan venom research utilised parenterally administered venom in their animal models, with many acknowledging their questionable applicability to real-world envenomation. Our model used live cubozoans on anaesthetised mice to simulate normal envenomation mechanics and actual expressed venoms. Consequently, we provide validity to the parenteral methodology used by previous cubozoan venom research.en
dc.language.isoenen
dc.relation.ispartofToxinsen
dc.subjectCarukia barnesien
dc.subjectDoppleren
dc.subjectIrukandjien
dc.subjecttentacleen
dc.subjectvenomen
dc.titleDifferences in Cardiac Effects of Venoms from Tentacles and the Bell of Live Carukia barnesi: Using Non-Invasive Pulse Wave Doppleren
dc.typeArticleen
dc.identifier.doi10.3390/toxins13010019-
dc.identifier.pmid33383955-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairetypeArticle-
Appears in Sites:Cairns & Hinterland HHS Publications
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