Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/4675
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dc.contributor.authorRiney, K.en
dc.contributor.authorWatt, K.en
dc.contributor.authorO'Brien, S.en
dc.contributor.authorWilson, C.en
dc.contributor.authorBabl, F. E.en
dc.contributor.authorDalziel, S. R.en
dc.contributor.authorBorland, M. L.en
dc.contributor.authorHearps, S. J. C.en
dc.contributor.authorFuryk, J. S.en
dc.contributor.authorGeorge, S.en
dc.contributor.authorPhillips, N.en
dc.contributor.authorEmeto, T. I.en
dc.date.accessioned2022-11-07T23:55:12Z-
dc.date.available2022-11-07T23:55:12Z-
dc.date.issued2022en
dc.identifier.citation, 2022en
dc.identifier.otherRISen
dc.identifier.urihttp://dora.health.qld.gov.au/qldresearchjspui/handle/1/4675-
dc.description.abstractObjective: Paediatric status epilepticus (SE) has potential for long-term sequelae. Existing data demonstrate delays to aspects of care. The objective of the present study was to examine the feasibility of collecting data on children with paediatric SE and describe current management strategies in pre-hospital and in-hospital settings. Methods: A pilot, prospective, observational cohort study of children 4 weeks to 16 years of age with SE, in four EDs in Australia. Clinical details including medications administered, duration of seizure and short-term outcomes were collected. Follow up occurred by telephone at 1 month. Results: We enrolled 167 children with SE. Mean age was 5.4 years (standard deviation [SD] 4.1), and 81 (49%) male. Median seizure duration was 10 min (interquartile range 7–30). Midazolam was the first medication administered in 87/100 (87%) instances, mean dose of 0.21 mg/kg (SD 0.13). The dose of midazolam was adequate in 30 (35%), high (>0.2 mg/kg) in 44 (51%) and low (<0.1 mg/kg) in 13 (15%). For second-line agents, levetiracetam was administered on 33/55 (60%) occasions, whereas phenytoin and phenobarbitone were administered on 11/55 (20%) occasions each. Mean dose of levetiracetam was 26.4 mg/kg (SD 13.5). One hundred and four (62%) patients were admitted to hospital, with 13 (8%) admitted to ICU and seven (4%) intubated. Conclusion: In children presenting with SE in Australia medical management differed from previous reports, with midazolam as the preferred benzodiazepine, and levetiracetam replacing phenytoin as the preferred second-line agent. This pilot study indicates the feasibility of a paediatric SE registry and its utility to understand and optimise practice.L20159022232022-05-02 <br />en
dc.language.isoenen
dc.relation.ispartofEMA - Emergency Medicine Australasiaen
dc.titleStatus Epilepticus Australasian Registry for Children: A pilot prospective, observational, cohort study of paediatric status epilepticusen
dc.typeArticleen
dc.identifier.doi10.1111/1742-6723.13988en
dc.subject.keywordsdrug therapyen
dc.subject.keywordsepileptic stateen
dc.subject.keywordsfeasibility studyen
dc.subject.keywordsfemaleen
dc.subject.keywordsfollow upen
dc.subject.keywordshumanen
dc.subject.keywordsmajor clinical studyen
dc.subject.keywordsmaleen
dc.subject.keywordsoutcome assessmenten
dc.subject.keywordspilot studyen
dc.subject.keywordspreschool childen
dc.subject.keywordschilden
dc.subject.keywordsseizureen
dc.subject.keywordstelephoneen
dc.subject.keywordsbenzodiazepineen
dc.subject.keywordslevetiracetamen
dc.subject.keywordsmidazolamen
dc.subject.keywordsphenobarbitalen
dc.subject.keywordsphenytoinen
dc.subject.keywordsAustraliaen
dc.subject.keywordsadolescentarticleen
dc.subject.keywordsprospective studyen
dc.subject.keywordscohort analysisen
dc.subject.keywordscontrolled studyen
dc.relation.urlhttps://www.embase.com/search/results?subaction=viewrecord&id=L2015902223&from=exporthttp://dx.doi.org/10.1111/1742-6723.13988 |en
dc.identifier.risid1629en
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeArticle-
item.languageiso639-1en-
Appears in Sites:Children's Health Queensland Publications
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