Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/4257
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dc.contributor.authorRadford, D. J.en
dc.contributor.authorKonstantinov, I. E.en
dc.contributor.authorD'Udekem, Y.en
dc.contributor.authorBrizard, C. P.en
dc.contributor.authorAlphonso, N.en
dc.contributor.authorBuratto, E.en
dc.contributor.authorDaley, M.en
dc.contributor.authorYe, X. T.en
dc.date.accessioned2022-11-07T23:50:57Z-
dc.date.available2022-11-07T23:50:57Z-
dc.date.issued2018en
dc.identifier.citation104, (12), 2018, p. 1014-1018en
dc.identifier.otherRISen
dc.identifier.urihttp://dora.health.qld.gov.au/qldresearchjspui/handle/1/4257-
dc.description.abstractObjective Partial atrioventricular septal defect (pAVSD) is usually repaired between 2 and 4 years of age with excellent results. Repair during infancy has been associated with poorer outcomes. However, most infants in reported series had heart failure or significant left atrioventricular valve (LAVV) regurgitation. The impact of surgery during infancy on outcomes remains unclear. Methods A ll children at three institutions who underwent repair of pAVSD from 1975 to 2015 were included. Infants (aged <1 year) were compared with older children in a propensity score matched analysis. Variables used to generate propensity scores were: failure to thrive, congestive heart failure, preoperative LAVV regurgitation, associated congenital heart disease, sex and the presence of trisomy 21. Results pAVSD repair was performed on 430 children, 17.4% (75/430) were infants. Infants (mean age 0.5±0.3 years) had higher rates of LAVV regurgitation, heart failure and additional cardiac malformations than older children (mean age 4.7±3.5 years). At 30 years, survival for infants was 82.1% (95% CI 70.1% to 89.6%) compared with 95.7% (95% CI 91.3% to 97.9%) in older children (P<0.001). Propensity score matching yielded 52 well-matched pairs. Survival at 30 years was 87.9% (95% CI 75.0% to 94.4%) for infants compared with 98.1% (95% CI 87.1% to 99.7%) for older children (P=0.04). There was no significant difference in freedom from reoperation between the groups. Conclusions Despite matching for risk factors, survival after repair of pAVSD during infancy is lower than that when repair is performed in older children, with no difference in reoperation rates. This suggests that elective repair of pAVSD should be deferred until after infancy.L6254199792018-12-20 <br />2018-12-28 <br />en
dc.language.isoenen
dc.relation.ispartofHearten
dc.titlePropensity score matched analysis of partial atrioventricular septal defect repair in infancyen
dc.typeArticleen
dc.identifier.doi10.1136/heartjnl-2017-312163en
dc.subject.keywordsfemaleen
dc.subject.keywordshumanen
dc.subject.keywordsinfancyen
dc.subject.keywordsinfanten
dc.subject.keywordsmaleen
dc.subject.keywordsmitral valve regurgitationen
dc.subject.keywordspreschool childen
dc.subject.keywordspriority journalen
dc.subject.keywordspropensity scoreen
dc.subject.keywordsreoperationen
dc.subject.keywordsretrospective studyen
dc.subject.keywordscongenital heart diseaseen
dc.subject.keywordssternotomyen
dc.subject.keywordscohort analysisen
dc.subject.keywordschild deathen
dc.subject.keywordschilden
dc.subject.keywordssurvivalen
dc.subject.keywordstreatment outcomeen
dc.subject.keywordstrisomy 21en
dc.subject.keywordsarticleatrioventricular septal defecten
dc.subject.keywordssexen
dc.subject.keywordscongestive heart failureen
dc.subject.keywordscontrolled studyen
dc.subject.keywordsfailure to thriveen
dc.relation.urlhttps://www.embase.com/search/results?subaction=viewrecord&id=L625419979&from=exporthttp://dx.doi.org/10.1136/heartjnl-2017-312163 |en
dc.identifier.risid1178en
dc.description.pages1014-1018en
item.grantfulltextnone-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Sites:Children's Health Queensland Publications
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