Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/4136
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dc.contributor.authorDavies, J. C.en
dc.contributor.authorSly, P. D.en
dc.contributor.authorMcNally, P.en
dc.contributor.authorO'Rourke, J.en
dc.contributor.authorFantino, E.en
dc.contributor.authorChacko, A.en
dc.contributor.authorPabary, R.en
dc.contributor.authorTurnbull, A.en
dc.contributor.authorGrant, T.en
dc.contributor.authorO'Sullivan, N.en
dc.contributor.authorLinnane, B.en
dc.contributor.authorWainwright, C.en
dc.date.accessioned2022-11-07T23:49:42Z-
dc.date.available2022-11-07T23:49:42Z-
dc.date.issued2018en
dc.identifier.citation17, (3), 2018, p. 391-399en
dc.identifier.otherRISen
dc.identifier.urihttp://dora.health.qld.gov.au/qldresearchjspui/handle/1/4136-
dc.description.abstractBackground: Bronchoalveolar lavage (BAL) is a potentially useful outcome measure for clinical trials in children with CF but its use is limited by variations in approach internationally. We sought to determine if pooling adversely affected the diagnostic properties of BAL. Methods: Children undergoing bronchoscopy for clinical reasons were included. A multi-step study protocol ensured BAL was collected and analysed both separately and as a pooled fluid. Results: Eighty-five children (53 CF, 32 control) were recruited. There was a high level of concordance between pooled and non-pooled samples in terms of organism identification (76%). There was good agreement (Bland Altman) between the two methods in terms of detection of inflammation independent of centre, microbiological concordance or disease status. Bi-directional variability in IL-8 levels between pooled and non-pooled samples was seen. Free neutrophil elastase (NE) was detected in 4 cases in pooled lavage when absent in non-pooled lavage. Levels of interleukin-8 (IL-8) were similar between the two groups with pooled samples showing a greater spread of values. Conclusions: Pooling of BAL in children does not negatively impact on either the detection of pulmonary infection or inflammation or the observed relationship between infection and inflammation. Intra-patient variability in BAL IL-8 levels suggests regional differences in inflammation.L6193929232017-11-28 <br />2018-06-01 <br />en
dc.language.isoenen
dc.relation.ispartofJournal of Cystic Fibrosisen
dc.titlePooling of bronchoalveolar lavage in children with cystic fibrosis does not adversely affect the microbiological yield or sensitivity in detecting pulmonary inflammationen
dc.typeArticleen
dc.identifier.doi10.1016/j.jcf.2017.10.016en
dc.subject.keywordsMoraxella catarrhalisen
dc.subject.keywordspneumoniaen
dc.subject.keywordsPseudomonas aeruginosaen
dc.subject.keywordsreceiver operating characteristicen
dc.subject.keywordsrecurrent infectionen
dc.subject.keywordsspecimen handlingen
dc.subject.keywordsStenotrophomonas maltophiliaen
dc.subject.keywordsStreptococcus pneumoniaeen
dc.subject.keywordsthorax radiographyen
dc.subject.keywordswheezingen
dc.subject.keywordssensitivity and specificityen
dc.subject.keywordsflexible bronchoscopebiological markeren
dc.subject.keywordsinterleukin 8en
dc.subject.keywordsleukocyte elastaseen
dc.subject.keywordsarticleen
dc.subject.keywordsassayen
dc.subject.keywordsbronchoscopyen
dc.subject.keywordschilden
dc.subject.keywordscontrolled studyen
dc.subject.keywordscoughingen
dc.subject.keywordscroupen
dc.subject.keywordscystic fibrosisen
dc.subject.keywordscytokine releaseen
dc.subject.keywordsdiagnostic test accuracy studyen
dc.subject.keywordsdiagnostic valueen
dc.subject.keywordsgeneral anesthesiaen
dc.subject.keywordsHaemophilus influenzaeen
dc.subject.keywordshemoptysisen
dc.subject.keywordshumanen
dc.subject.keywordsinflammationen
dc.subject.keywordslung diseaseen
dc.subject.keywordslung infectionen
dc.subject.keywordslung lavageen
dc.subject.keywordsmajor clinical studyen
dc.subject.keywordsmicrobiological examinationen
dc.relation.urlhttps://www.embase.com/search/results?subaction=viewrecord&id=L619392923&from=exporthttp://dx.doi.org/10.1016/j.jcf.2017.10.016 |en
dc.identifier.risid1481en
dc.description.pages391-399en
item.grantfulltextnone-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Sites:Children's Health Queensland Publications
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