Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/4033
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dc.contributor.authorParkin, S.en
dc.contributor.authorDeWire-Schottmiller, M.en
dc.contributor.authorLane, A.en
dc.contributor.authorSaab, R.en
dc.contributor.authorBandopadhayay, P.en
dc.contributor.authorDorris, K.en
dc.contributor.authorPacker, R.en
dc.contributor.authorKilburn, L.en
dc.contributor.authorMinturn, J.en
dc.contributor.authorDodgshun, A.en
dc.contributor.authorGoldman, S.en
dc.contributor.authorSandler, E.en
dc.contributor.authorGreiner, R.en
dc.contributor.authorGottardo, N.en
dc.contributor.authorDholaria, H.en
dc.contributor.authorCoven, S. L.en
dc.contributor.authorHassall, T.en
dc.contributor.authorHansford, J.en
dc.contributor.authorSamson, Y.en
dc.contributor.authorLeary, S.en
dc.contributor.authorBartels, U.en
dc.contributor.authorBouffet, E.en
dc.contributor.authorTinkle, C.en
dc.contributor.authorMonje, M.en
dc.contributor.authorFisher, P. G.en
dc.contributor.authorZiegler, D.en
dc.contributor.authorChintagumpala, M.en
dc.contributor.authorWagner, L.en
dc.contributor.authorKoschmann, C.en
dc.contributor.authorBenito, E. C.en
dc.contributor.authorLeach, J.en
dc.contributor.authorJones, B.en
dc.contributor.authorChaney, B.en
dc.contributor.authorBlack, K.en
dc.contributor.authorAsher, A.en
dc.contributor.authorBond, H.en
dc.contributor.authorFouladi, M.en
dc.contributor.authorWarren, K. E.en
dc.contributor.authorCooney, T.en
dc.date.accessioned2022-11-07T23:48:37Z-
dc.date.available2022-11-07T23:48:37Z-
dc.date.issued2020en
dc.identifier.citation22, (SUPPL 3), 2020, p. iii297-iii298en
dc.identifier.otherRISen
dc.identifier.urihttp://dora.health.qld.gov.au/qldresearchjspui/handle/1/4033-
dc.description.abstractThere is no standard of care for cerebrospinal (CSF) diversion in children with diffuse intrinsic pontine glioma (DIPG), nor understanding of survival impact. We evaluated CSF diversion characteristics in children with DIPG to determine incidence, indications and potential impact on survival. Data was extracted from subjects registered in the International DIPG registry (IDIPGR). IDIPGR team personnel obtained clinical and radiographic data from the registry database and when appropriate, abstracted additional data from individual medical records. Univariable analyses were performed using the Fisher's exact test or Wilcoxon rank sum test. Survival was estimated using the Kaplan-Meier method. Evaluable patients (n=457) met criteria for DIPG diagnosis by central radiology review. Ninety-two patients (20%) had permanent CSF diversion. Indications for permanent diversion were hydrocephalus (41%), hydrocephalus and clinical symptoms (35%), and clinical symptoms alone (3%). Those with permanent diversion were significantly younger at diagnosis than those without diversion (median 5.3 years vs 6.9 years, p=0.0002), otherwise no significant differences in gender, race, or treatment were found. The progression-free and overall survival of those with permanent CSF diversion compared to those without permanent diversion was 4.5 and 10.9 months vs 6.9 and 11.2 months, respectively (p=0.001, p= 0.4). There was no significant difference in overall survival in patients with or without permanent CSF diversion among a large cohort of DIPG patients. Patients without permanent diversion had significantly prolonged progression free survival compared to those with permanent diversion. The qualitative risks and benefits of permanent CSF diversion need to be further evaluated.L6341307492021-02-12 <br />en
dc.language.isoenen
dc.relation.ispartofNeuro-Oncologyen
dc.titlePatterns of cerebrospinal fluid diversion and survival in children with diffuse intrinsic pontine glioma: A report from the international DIPG registryen
dc.typeArticleen
dc.identifier.doi10.1093/neuonc/noaa222en
dc.subject.keywordsradiologyen
dc.subject.keywordsrank sum testen
dc.subject.keywordspontine gliomaen
dc.subject.keywordsprogression free survivalen
dc.subject.keywordsraceen
dc.subject.keywordscancer patientcancer survivalen
dc.subject.keywordscerebrospinal fluiden
dc.subject.keywordschilden
dc.subject.keywordscohort analysisen
dc.subject.keywordsconference abstracten
dc.subject.keywordscontrolled studyen
dc.subject.keywordsfemaleen
dc.subject.keywordsgenderen
dc.subject.keywordshumanen
dc.subject.keywordshydrocephalusen
dc.subject.keywordsincidenceen
dc.subject.keywordsKaplan Meier methoden
dc.subject.keywordsmajor clinical studyen
dc.subject.keywordsmaleen
dc.subject.keywordsmedical recorden
dc.subject.keywordsoverall survivalen
dc.relation.urlhttps://www.embase.com/search/results?subaction=viewrecord&id=L634130749&from=exporthttp://dx.doi.org/10.1093/neuonc/noaa222 |en
dc.identifier.risid2643en
dc.description.pagesiii297-iii298en
item.grantfulltextnone-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Sites:Children's Health Queensland Publications
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