| Title: | Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns |
Authors: | Rietschel, M.
Weinsheimer, S. M.
Wellmann, J.
Willemsen, G.
Witt, S. H.
Wu, Y.
Xi, H. S.
Yang, J.
Zhang, F.
Arolt, V.
Baune, B. T.
Abdellaoui, A.
Adams, M. J.
Agerbo, E.
Air, T. M.
Andlauer, T. F. M.
Bacanu, S. A.
Bækvad-Hansen, M.
Beekman, A. T. F.
Bigdeli, T. B.
Blackwood, D. H. R.
Berger, K.
Bryois, J.
Buttenschøn, H. N.
Bybjerg-Grauholm, J.
Cai, N.
Castelao, E.
Christensen, J. H.
Clarke, T. K.
Coleman, J. R. I.
Colodro-Conde, L.
Couvy-Duchesne, B.
Boomsma, D. I.
Craddock, N.
Crawford, G. E.
Davies, G.
Deary, I. J.
Degenhardt, F.
Derks, E. M.
Direk, N.
Dolan, C. V.
Dunn, E. C.
Eley, T. C.
Cichon, S.
Escott-Price, V.
Kiadeh, F. F. H.
Finucane, H. K.
Forstner, A. J.
Frank, J.
Gaspar, H. A.
Gill, M.
Goes, F. S.
Gordon, S. D.
Grove, J.
Dannlowski, U.
Hall, L. S.
Hansen, C. S.
Hansen, T. F.
Herms, S.
Hickie, I. B.
Hoffmann, P.
Homuth, G.
Horn, C.
Hottenga, J. J.
Hougaard, D. M.
de Geus, E. J. C.
Ising, M.
Jansen, R.
Jorgenson, E.
Knowles, J. A.
Kohane, I. S.
Kraft, J.
Kretzschmar, W. W.
Krogh, J.
Kutalik, Z.
Li, Y.
DePaulo, J. R.
Lind, P. A.
MacIntyre, D. J.
MacKinnon, D. F.
Maier, R. M.
Maier, W.
Marchini, J.
Mbarek, H.
McGrath, P.
McGuffin, P.
Medland, S. E.
Domenici, E.
Mehta, D.
Middeldorp, C. M.
Mihailov, E.
Milaneschi, Y.
Milani, L.
Mondimore, F. M.
Montgomery, G. W.
Mostafavi, S.
Mullins, N.
Nauck, M.
Domschke, K.
Ng, B.
Nivard, M. G.
Nyholt, D. R.
O’Reilly, P. F.
Oskarsson, H.
Owen, M. J.
Painter, J. N.
Pedersen, C. B.
Pedersen, M. G.
Peterson, R. E.
Esko, T.
Pettersson, E.
Peyrot, W. J.
Pistis, G.
Posthuma, D.
Quiroz, J. A.
Qvist, P.
Rice, J. P.
Riley, B. P.
Rivera, M.
Mirza, S. S.
Grabe, H. J.
Schoevers, R.
Schulte, E. C.
Shen, L.
Shi, J.
Shyn, S. I.
Sigurdsson, E.
Sinnamon, G. C. B.
Smit, J. H.
Smith, D. J.
Stefansson, H.
Hamilton, S. P.
Steinberg, S.
Streit, F.
Strohmaier, J.
Tansey, K. E.
Teismann, H.
Teumer, A.
Thompson, W.
Thomson, P. A.
Thorgeirsson, T. E.
Traylor, M.
Hayward, C.
Treutlein, J.
Trubetskoy, V.
Uitterlinden, A. G.
Umbricht, D.
Van der Auwera, S.
van Hemert, A. M.
Viktorin, A.
Wang, Y.
Webb, B. T.
Heath, A. C.
Kendler, K. S.
Kloiber, S.
Lewis, G.
Li, Q. S.
Lucae, S.
Madden, P. A. F.
Magnusson, P. K.
Martin, N. G.
McIntosh, A. M.
Metspalu, A.
Mors, O.
Mortensen, P. B.
Müller-Myhsok, B.
Nordentoft, M.
Nöthen, M. M.
O’Donovan, M. C.
Paciga, S. A.
Pedersen, N. L.
Penninx, B. W. J. H.
Perlis, R. H.
Porteous, D. J.
Potash, J. B.
Preisig, M.
Schaefer, C.
Schulze, T. G.
Smoller, J. W.
Stefansson, K.
Tiemeier, H.
Uher, R.
Völzke, H.
Weissman, M. M.
Werge, T.
Lewis, C. M.
Levinson, D. F.
Breen, G.
Børglum, A. D.
Sullivan, P. F.
Räikkönen, K.
Binder, E. B.
Visscher, P. M.
Czamara, D.
Eraslan, G.
Page, C. M.
Lahti, J.
Lahti-Pulkkinen, M.
Hämäläinen, E.
Kajantie, E.
Laivuori, H.
Villa, P. M.
Reynolds, R. M.
Nystad, W.
Håberg, S. E.
London, S. J.
O’Donnell, K. J.
Garg, E.
Meaney, M. J.
Entringer, S.
Wadhwa, P. D.
Buss, C.
Jones, M. J.
Lin, D. T. S.
MacIsaac, J. L.
Kobor, M. S.
Koen, N.
Zar, H. J.
Koenen, K. C.
Dalvie, S.
Stein, D. J.
Kondofersky, I.
Müller, N. S.
Theis, F. J.
Wray, N. R.
Ripke, S.
Mattheisen, M.
Trzaskowski, M.
Byrne, E. M. |
Issue Date: | 2019 |
Source: | 10, (1), 2019 |
Journal: | Nature Communications |
Abstract: | | Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike’s information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.L6280434932019-06-20
2019-06-25
DOI: | 10.1038/s41467-019-10461-0 |
Resources: | https://www.embase.com/search/results?subaction=viewrecord&id=L628043493&from=exporthttp://dx.doi.org/10.1038/s41467-019-10461-0
| |
Keywords: | CpG island;DNA methylation;environmental factor;epigenetics;female;gene expression;gene interaction;gene mapping;genetic analysis;genetic variability;genome-wide association study;genotyping;gestational age;heredity;human;hypertension;inflammatory bowel disease;major depression;male;maternal age;maternal hypertension;maternal smoking;newborn;oral glucose tolerance test;overlapping gene;parity;phenotype;preeclampsia;pregnancy diabetes mellitus;quality control;quantitative trait locus;single nucleotide polymorphism;State Trait Anxiety Inventory;umbilical cord blood;vaginal delivery;schizophrenia;betamethasoneanxiety;article;attention deficit hyperactivity disorder;autism;bipolar disorder;blood sampling;cell function;cell heterogeneity;Center for Epidemiological Studies Depression Scale;cesarean section;cohort analysis;comparative study |
Type: | Article |
| Appears in Sites: | Children's Health Queensland Publications
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