Please use this identifier to cite or link to this item:
https://dora.health.qld.gov.au/qldresearchjspui/handle/1/3388
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DC Field | Value | Language |
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dc.contributor.author | Booy, Robert | en |
dc.contributor.author | Li‐Kim‐Moy, Jean P. | en |
dc.contributor.author | Yin, Jiehui K. | en |
dc.contributor.author | Heron, Leon | en |
dc.contributor.author | Leask, Julie | en |
dc.contributor.author | Lambert, Stephen B. | en |
dc.contributor.author | Nissen, Michael | en |
dc.contributor.author | Sloots, Theo | en |
dc.date.accessioned | 2022-11-07T23:41:48Z | - |
dc.date.available | 2022-11-07T23:41:48Z | - |
dc.date.issued | 2017 | en |
dc.identifier.citation | 53, (1), 2017, p. 47-54 | en |
dc.identifier.other | RIS | en |
dc.identifier.uri | http://dora.health.qld.gov.au/qldresearchjspui/handle/1/3388 | - |
dc.description.abstract | Aim: Influenza causes a substantial burden in young children. Vaccine efficacy (VE) data are limited in this age group. We examined trivalent influenza vaccine (TIV) efficacy and safety in young children attending childcare.Methods: A double-blind, randomised controlled trial in children aged 6 to <48 months was conducted with recruitment from Sydney childcare centres in 2011. Children were randomised to receive two doses of TIV or control hepatitis A vaccine. Efficacy was evaluated against polymerase chain reaction-confirmed influenza using parent-collected nose/throat swabs during influenza-like-illness. Safety outcomes were assessed during 6 months of follow-up.Results: Fifty-seven children were allocated to influenza vaccine and 67 to control; all completed the study. The influenza attack rate was 1.8 vs 13.4% in the TIV and control groups, respectively; VE 87% (95%CI: 0-98%). For children aged 24 to <48 months, 0 vs 8 (18.6%) influenza infections occurred in the TIV and control groups respectively, giving a VE of 100% (16-100%). Efficacy was not shown in children 6 to <24 months, probably due to insufficient power. Injection site and systemic adverse events were mostly mild to moderate with no significant differences, apart from more mild diarrhoea following dose 2 in TIV recipients (11.8 vs 0%).Conclusions: Influenza vaccine appeared efficacious in the subgroup of children aged 24 to <48 months, although caution is required due to the small number of participants. There were no serious adverse events and most parents would vaccinate again. Influenza vaccination in a childcare setting could be valuable and a larger confirmatory study would be helpful.research; randomized controlled trial. Journal Subset: Australia & New Zealand; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed. Special Interest: Evidence-Based Practice. NLM UID: 9005421.PMID: NLM27592696. <br /> | en |
dc.language.iso | en | en |
dc.relation.ispartof | Journal of Paediatrics & Child Health | en |
dc.title | Influenza vaccine efficacy in young children attending childcare: A randomised controlled trial | en |
dc.type | Article | en |
dc.identifier.doi | 10.1111/jpc.13313 | en |
dc.subject.keywords | Hepatitis A -- Prevention and Control | en |
dc.subject.keywords | Human | en |
dc.subject.keywords | Hepatitis A Vaccines -- Administration and Dosage | en |
dc.subject.keywords | Influenza Vaccine -- Administration and Dosage | en |
dc.subject.keywords | Vaccines | en |
dc.subject.keywords | Child, Preschool | en |
dc.subject.keywords | Treatment Outcomes | en |
dc.subject.keywords | Middle Age | en |
dc.subject.keywords | Female | en |
dc.subject.keywords | Male | en |
dc.subject.keywords | Influenza, Human -- Prevention and Control | en |
dc.subject.keywords | Validation Studies | en |
dc.subject.keywords | Comparative Studies | en |
dc.subject.keywords | Evaluation Research | en |
dc.subject.keywords | Multicenter Studies | en |
dc.subject.keywords | Randomized Controlled Trials | en |
dc.subject.keywords | Influenza Vaccine -- StandardsChild Care | en |
dc.subject.keywords | Data Collection | en |
dc.subject.keywords | Adult | en |
dc.subject.keywords | Infant | en |
dc.subject.keywords | Double-Blind Studies | en |
dc.relation.url | https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,athens&db=ccm&AN=120629137&site=ehost-live | en |
dc.identifier.risid | 3869 | en |
dc.description.pages | 47-54 | en |
item.grantfulltext | none | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
Appears in Sites: | Children's Health Queensland Publications |
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