Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/3388
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dc.contributor.authorBooy, Roberten
dc.contributor.authorLi‐Kim‐Moy, Jean P.en
dc.contributor.authorYin, Jiehui K.en
dc.contributor.authorHeron, Leonen
dc.contributor.authorLeask, Julieen
dc.contributor.authorLambert, Stephen B.en
dc.contributor.authorNissen, Michaelen
dc.contributor.authorSloots, Theoen
dc.date.accessioned2022-11-07T23:41:48Z-
dc.date.available2022-11-07T23:41:48Z-
dc.date.issued2017en
dc.identifier.citation53, (1), 2017, p. 47-54en
dc.identifier.otherRISen
dc.identifier.urihttp://dora.health.qld.gov.au/qldresearchjspui/handle/1/3388-
dc.description.abstractAim: Influenza causes a substantial burden in young children. Vaccine efficacy (VE) data are limited in this age group. We examined trivalent influenza vaccine (TIV) efficacy and safety in young children attending childcare.Methods: A double-blind, randomised controlled trial in children aged 6 to <48 months was conducted with recruitment from Sydney childcare centres in 2011. Children were randomised to receive two doses of TIV or control hepatitis A vaccine. Efficacy was evaluated against polymerase chain reaction-confirmed influenza using parent-collected nose/throat swabs during influenza-like-illness. Safety outcomes were assessed during 6 months of follow-up.Results: Fifty-seven children were allocated to influenza vaccine and 67 to control; all completed the study. The influenza attack rate was 1.8 vs 13.4% in the TIV and control groups, respectively; VE 87% (95%CI: 0-98%). For children aged 24 to <48 months, 0 vs 8 (18.6%) influenza infections occurred in the TIV and control groups respectively, giving a VE of 100% (16-100%). Efficacy was not shown in children 6 to <24 months, probably due to insufficient power. Injection site and systemic adverse events were mostly mild to moderate with no significant differences, apart from more mild diarrhoea following dose 2 in TIV recipients (11.8 vs 0%).Conclusions: Influenza vaccine appeared efficacious in the subgroup of children aged 24 to <48 months, although caution is required due to the small number of participants. There were no serious adverse events and most parents would vaccinate again. Influenza vaccination in a childcare setting could be valuable and a larger confirmatory study would be helpful.research; randomized controlled trial. Journal Subset: Australia & New Zealand; Biomedical; Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed. Special Interest: Evidence-Based Practice. NLM UID: 9005421.PMID: NLM27592696. <br />en
dc.language.isoenen
dc.relation.ispartofJournal of Paediatrics & Child Healthen
dc.titleInfluenza vaccine efficacy in young children attending childcare: A randomised controlled trialen
dc.typeArticleen
dc.identifier.doi10.1111/jpc.13313en
dc.subject.keywordsHepatitis A -- Prevention and Controlen
dc.subject.keywordsHumanen
dc.subject.keywordsHepatitis A Vaccines -- Administration and Dosageen
dc.subject.keywordsInfluenza Vaccine -- Administration and Dosageen
dc.subject.keywordsVaccinesen
dc.subject.keywordsChild, Preschoolen
dc.subject.keywordsTreatment Outcomesen
dc.subject.keywordsMiddle Ageen
dc.subject.keywordsFemaleen
dc.subject.keywordsMaleen
dc.subject.keywordsInfluenza, Human -- Prevention and Controlen
dc.subject.keywordsValidation Studiesen
dc.subject.keywordsComparative Studiesen
dc.subject.keywordsEvaluation Researchen
dc.subject.keywordsMulticenter Studiesen
dc.subject.keywordsRandomized Controlled Trialsen
dc.subject.keywordsInfluenza Vaccine -- StandardsChild Careen
dc.subject.keywordsData Collectionen
dc.subject.keywordsAdulten
dc.subject.keywordsInfanten
dc.subject.keywordsDouble-Blind Studiesen
dc.relation.urlhttps://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,athens&db=ccm&AN=120629137&site=ehost-liveen
dc.identifier.risid3869en
dc.description.pages47-54en
item.grantfulltextnone-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Sites:Children's Health Queensland Publications
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