Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/3369
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dc.contributor.authorTu, Q.en
dc.contributor.authorGraham, N.en
dc.contributor.authorRaman, S.en
dc.contributor.authorCotta, M.en
dc.contributor.authorRoberts, J. A.en
dc.contributor.authorSchlapbach, L.en
dc.date.accessioned2022-11-07T23:41:35Z-
dc.date.available2022-11-07T23:41:35Z-
dc.date.issued2021en
dc.identifier.citation14, (11), 2021, p. 1383-1399en
dc.identifier.otherRISen
dc.identifier.urihttp://dora.health.qld.gov.au/qldresearchjspui/handle/1/3369-
dc.description.abstractIntroduction: Severe infections continue to impose a major burden on critically ill children and mortality rates remain stagnant. Outcomes rely on accurate and timely delivery of antimicrobials achieving target concentrations in infected tissue. Yet, developmental aspects, disease-related variables, and host factors may severely alter antimicrobial pharmacokinetics in pediatrics. The emergence of antimicrobial resistance increases the need for improved treatment approaches. Areas covered: This narrative review explores why optimization of antimicrobial therapy in neonates, infants, children, and adolescents is crucial and summarizes the possible dosing approaches to achieve antimicrobial individualization. Finally, we outline a roadmap toward scientific evidence informing the development and implementation of precision antimicrobial dosing in critically ill children. The literature search was conducted on PubMed using the following keywords: neonate, infant, child, adolescent, pediatrics, antimicrobial, pharmacokinetic, pharmacodynamic target, Bayes dosing software, optimizing, individualizing, personalizing, precision dosing, drug monitoring, validation, attainment, and software implementation. Further articles were sought from the references of the above searched articles. Expert opinion: Recently, technological innovations have emerged that enabled the development of individualized antimicrobial dosing approaches in adults. More work is required in pediatrics to make individualized antimicrobial dosing approaches widely operationalized in this population.L20133733482021-08-13 <br />2022-02-15 <br />en
dc.language.isoenen
dc.relation.ispartofExpert Review of Clinical Pharmacologyen
dc.titleIndividualized precision dosing approaches to optimize antimicrobial therapy in pediatric populationsen
dc.typeArticleen
dc.identifier.doi10.1080/17512433.2021.1961578en
dc.subject.keywordsgentamicinen
dc.subject.keywordsisoniaziden
dc.subject.keywordslinezoliden
dc.subject.keywordsmeropenemen
dc.subject.keywordsmoxifloxacinen
dc.subject.keywordspiperacillinen
dc.subject.keywordspyrazinamideen
dc.subject.keywordsrifampicinen
dc.subject.keywordstobramycinen
dc.subject.keywordsvancomycinen
dc.subject.keywordsallometryen
dc.subject.keywordsantibiotic resistanceen
dc.subject.keywordsantimicrobial therapyen
dc.subject.keywordsarticleen
dc.subject.keywordsartificial intelligenceen
dc.subject.keywordsbooken
dc.subject.keywordscost effectiveness analysisen
dc.subject.keywordscritical illnessen
dc.subject.keywordscritically ill patienten
dc.subject.keywordsdose responseen
dc.subject.keywordsdrug absorptionen
dc.subject.keywordsdrug distributionen
dc.subject.keywordsdrug eliminationen
dc.subject.keywordsdrug metabolismen
dc.subject.keywordsdrug monitoringen
dc.subject.keywordshumanen
dc.subject.keywordsinfectious agenten
dc.subject.keywordslinear regression analysisen
dc.subject.keywordsmental capacityen
dc.subject.keywordsnomogramen
dc.subject.keywordspediatric patienten
dc.subject.keywordspharmacodynamic parametersen
dc.subject.keywordspharmacokinetic parametersen
dc.subject.keywordsdaptomycinen
dc.subject.keywordsclindamycinen
dc.subject.keywordsceftazidimeen
dc.subject.keywordsantiinfective agentcefotaximeen
dc.subject.keywordsethambutolen
dc.relation.urlhttps://www.embase.com/search/results?subaction=viewrecord&id=L2013373348&from=exporthttp://dx.doi.org/10.1080/17512433.2021.1961578 |en
dc.identifier.risid1940en
dc.description.pages1383-1399en
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.openairetypeArticle-
item.grantfulltextnone-
item.fulltextNo Fulltext-
Appears in Sites:Children's Health Queensland Publications
Queensland Health Publications
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