Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/3292
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dc.contributor.authorKonstantinov, I. E.en
dc.contributor.authorGrigg, L.en
dc.contributor.authorIyengar, A.en
dc.contributor.authorAlphonso, N.en
dc.contributor.authorBullock, A.en
dc.contributor.authorCelermajer, D. S.en
dc.contributor.authorAyer, J.en
dc.contributor.authorRobertson, T.en
dc.contributor.authord'Udekem, Y.en
dc.contributor.authorDaley, M.en
dc.contributor.authorBuratto, E.en
dc.contributor.authorKing, G.en
dc.date.accessioned2022-11-07T23:40:50Z-
dc.date.available2022-11-07T23:40:50Z-
dc.date.issued2022en
dc.identifier.citationJun 7 11, (11), 2022, p. e026087en
dc.identifier.otherRISen
dc.identifier.urihttp://dora.health.qld.gov.au/qldresearchjspui/handle/1/3292-
dc.description.abstractBackground The long-term impact of fenestration at the time of Fontan operation remains unclear. We aimed to review the early and long-term impact of Fontan fenestration in the Australia and New Zealand cohort. Methods and Results We reviewed 1443 patients (621 fenestrated, 822 nonfenestrated) from the Australia and New Zealand Fontan registry. Data were collected on preoperative demographics, operative details, and follow-up. Propensity-score matching was performed to account for the various preoperative and operative differences and risk factors. Primary outcomes were survival and freedom from failure. Median follow-up was 10.6 years. After propensity-score matching (407 matched pairs), there was no difference in survival (87% versus 90% at 20 years; P=0.16) or freedom from failure (73% versus 80% at 20 years; P=0.10) between patients with and without fenestration, respectively. Although patients with fenestration had longer bypass and cross-clamp times (P<0.001), there was no difference in hospital length of stay or prolonged pleural effusions (P=0.80 and P=0.46, respectively). Freedom from systemic and Fontan circuit thromboembolism was higher in the nonfenestrated group (89%; 95% CI, 88%-95%) than the fenestrated group (84%; 95% CI, 77%-89%; P=0.03). There was no difference in incidence of plastic bronchitis, protein-losing enteropathy, New York Heart Association Class III/IV symptoms, or Fontan takedown. Conclusions In the propensity score-matched analysis we have demonstrated no difference in long-term survival or freedom from Fontan failure in patients with and without fenestration. There was a higher incidence of long-term thromboembolic events in patients with fenestration. Overall, it appears that fenestration in Fontan circulation does not bring long-term benefits.2047-9980Daley, Michael <br />Orcid: 0000-0002-2016-7057 <br />Buratto, Edward <br />Orcid: 0000-0002-8330-3917 <br />King, Gregory <br />Orcid: 0000-0001-6288-1702 <br />Grigg, Leeanne <br />Iyengar, Ajay <br />Alphonso, Nelson <br />Orcid: 0000-0002-3735-8298 <br />Bullock, Andrew <br />Celermajer, David S <br />Orcid: 0000-0001-7640-0439 <br />Ayer, Julian <br />Robertson, Terry <br />d'Udekem, Yves <br />Konstantinov, Igor E <br />Orcid: 0000-0002-9981-1123 <br />Journal Article <br />J Am Heart Assoc. 2022 Jun 7;11(11):e026087. doi: 10.1161/JAHA.122.026087. Epub 2022 May 27. <br />en
dc.language.isoenen
dc.relation.ispartofJ Am Heart Assocen
dc.titleImpact of Fontan Fenestration on Long-Term Outcomes: A Propensity Score-Matched Analysisen
dc.typeArticleen
dc.identifier.doi10.1161/jaha.122.026087en
dc.subject.keywordsRisk Factorsen
dc.subject.keywords*Thromboembolism/etiologyen
dc.subject.keywordsTreatment Outcomeen
dc.subject.keywordsfenestrationen
dc.subject.keywordsrisk factoren
dc.subject.keywordsHumansen
dc.subject.keywordsthromboembolismen
dc.subject.keywordsuniventricularen
dc.subject.keywords*Fontan Procedure/adverse effects/methods*Heart Defects, Congenitalen
dc.subject.keywordssurvivalen
dc.subject.keywordsPostoperative Complications/epidemiology/etiologyen
dc.subject.keywordsPropensity Scoreen
dc.subject.keywordsRetrospective Studiesen
dc.identifier.risid3052en
dc.description.pagese026087en
item.grantfulltextnone-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Sites:Children's Health Queensland Publications
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