Please use this identifier to cite or link to this item:
https://dora.health.qld.gov.au/qldresearchjspui/handle/1/3015
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DC Field | Value | Language |
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dc.contributor.author | Maćkowiak, N. | en |
dc.contributor.author | Kaczorowska-Frontczak, M. | en |
dc.contributor.author | Lehmann, K. | en |
dc.contributor.author | Leusman, A. | en |
dc.contributor.author | Mills, J. | en |
dc.contributor.author | Urbańska, M. | en |
dc.contributor.author | Vervisch, J. | en |
dc.contributor.author | Verhelle, B. | en |
dc.contributor.author | van Scheppingen, J. | en |
dc.contributor.author | Tempes, A. | en |
dc.contributor.author | Slowinska, M. | en |
dc.contributor.author | Sciuto, A. | en |
dc.contributor.author | Scheldeman, C. | en |
dc.contributor.author | Muelebner, A. | en |
dc.contributor.author | Hulshof, H. M. | en |
dc.contributor.author | Slot, E. M. H. | en |
dc.contributor.author | Lequin, M. | en |
dc.contributor.author | Breuillard, D. | en |
dc.contributor.author | Boddaert, N. | en |
dc.contributor.author | Jozwiak, S. | en |
dc.contributor.author | Kotulska, K. | en |
dc.contributor.author | Riney, K. | en |
dc.contributor.author | Feucht, M. | en |
dc.contributor.author | Samueli, S. | en |
dc.contributor.author | Scholl, T. | en |
dc.contributor.author | Krsek, P. | en |
dc.contributor.author | Benova, B. | en |
dc.contributor.author | Braun, K. P. J. | en |
dc.contributor.author | Jansen, F. E. | en |
dc.contributor.author | Nabbout, R. | en |
dc.contributor.author | Curatolo, P. | en |
dc.contributor.author | Lagae, L. | en |
dc.contributor.author | Jansen, A. | en |
dc.contributor.author | Aronica, E. | en |
dc.contributor.author | Kwiatkowski, D. | en |
dc.contributor.author | Weschke, B. | en |
dc.contributor.author | Wojdan, K. | en |
dc.contributor.author | Sijko, K. | en |
dc.contributor.author | Głowacka, J. | en |
dc.contributor.author | Borkowska, J. | en |
dc.contributor.author | Sadowski, K. | en |
dc.contributor.author | Domańska-Pakieła, D. | en |
dc.contributor.author | Anink, J. | en |
dc.contributor.author | Benvenuto, A. | en |
dc.contributor.author | Blazejczyk, M. | en |
dc.contributor.author | Bongaerts, A. | en |
dc.contributor.author | Chmielewski, D. | en |
dc.contributor.author | Dabrowska, M. | en |
dc.contributor.author | De Ridder, J. | en |
dc.contributor.author | Giannikou, K. | en |
dc.contributor.author | Hamieh, L. | en |
dc.contributor.author | Haręza, A. | en |
dc.contributor.author | Iyer, A. | en |
dc.contributor.author | Janssen, B. | en |
dc.contributor.author | Jaworski, J. | en |
dc.date.accessioned | 2022-11-07T23:37:41Z | - |
dc.date.available | 2022-11-07T23:37:41Z | - |
dc.date.issued | 2021 | en |
dc.identifier.citation | 233 , 2021, p. 156-162.e2 | en |
dc.identifier.other | RIS | en |
dc.identifier.uri | http://dora.health.qld.gov.au/qldresearchjspui/handle/1/3015 | - |
dc.description.abstract | Objective: To correlate fetal brain magnetic resonance imaging (MRI) findings with epilepsy characteristics and neurodevelopment at 2 years of age in children with tuberous sclerosis complex (TSC) to improve prenatal counseling. Study design: This retrospective cohort study was performed in a collaboration between centers of the EPISTOP consortium. We included children with definite TSC, fetal MRIs, and available follow-up data at 2 years of age. A pediatric neuroradiologist masked to the patient's clinical characteristics evaluated all fetal MRIs. MRIs were categorized for each of the 10 brain lobes as score 0: no (sub)cortical lesions or doubt; score 1: a single small lesion; score 2: more than one small lesion or at least one large lesion (>5 mm). Neurologic manifestations were correlated to lesion sum scores. Results: Forty-one children were included. Median gestational age at MRI was 33.3 weeks; (sub)cortical lesions were detected in 97.6%. Mean lesion sum score was 4.5. At 2 years, 58.5% of patients had epilepsy and 22% had drug-resistant epilepsy. Cognitive, language, and motor development were delayed in 38%, 81%, and 50% of patients, respectively. Autism spectrum disorder (ASD) was diagnosed in 20.5%. Fetal MRI lesion sum scores were significantly associated with cognitive and motor development, and with ASD diagnosis, but not with epilepsy characteristics. Conclusions: Fetal cerebral lesion scores correlate with neurodevelopment and ASD at 2 years in children with TSC.L20115786872021-04-12 <br />2021-07-13 <br /> | en |
dc.language.iso | en | en |
dc.relation.ispartof | Journal of Pediatrics | en |
dc.title | Fetal Brain Magnetic Resonance Imaging Findings Predict Neurodevelopment in Children with Tuberous Sclerosis Complex | en |
dc.type | Article | en |
dc.identifier.doi | 10.1016/j.jpeds.2021.02.060 | en |
dc.subject.keywords | retrospective study | en |
dc.subject.keywords | articleautism | en |
dc.subject.keywords | brain cortex lesion | en |
dc.subject.keywords | child | en |
dc.subject.keywords | clinical feature | en |
dc.subject.keywords | cognitive development | en |
dc.subject.keywords | cohort analysis | en |
dc.subject.keywords | epilepsy | en |
dc.subject.keywords | fetus | en |
dc.subject.keywords | fetus brain | en |
dc.subject.keywords | follow up | en |
dc.subject.keywords | gestational age | en |
dc.subject.keywords | human | en |
dc.subject.keywords | language development | en |
dc.subject.keywords | major clinical study | en |
dc.subject.keywords | motor development | en |
dc.subject.keywords | nervous system development | en |
dc.subject.keywords | nuclear magnetic resonance imaging | en |
dc.subject.keywords | preschool child | en |
dc.subject.keywords | tuberous sclerosis | en |
dc.subject.keywords | priority journal | en |
dc.relation.url | https://www.embase.com/search/results?subaction=viewrecord&id=L2011578687&from=exporthttp://dx.doi.org/10.1016/j.jpeds.2021.02.060 | | en |
dc.identifier.risid | 2649 | en |
dc.description.pages | 156-162.e2 | en |
item.grantfulltext | none | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
Appears in Sites: | Children's Health Queensland Publications |
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