Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/3015
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dc.contributor.authorMaćkowiak, N.en
dc.contributor.authorKaczorowska-Frontczak, M.en
dc.contributor.authorLehmann, K.en
dc.contributor.authorLeusman, A.en
dc.contributor.authorMills, J.en
dc.contributor.authorUrbańska, M.en
dc.contributor.authorVervisch, J.en
dc.contributor.authorVerhelle, B.en
dc.contributor.authorvan Scheppingen, J.en
dc.contributor.authorTempes, A.en
dc.contributor.authorSlowinska, M.en
dc.contributor.authorSciuto, A.en
dc.contributor.authorScheldeman, C.en
dc.contributor.authorMuelebner, A.en
dc.contributor.authorHulshof, H. M.en
dc.contributor.authorSlot, E. M. H.en
dc.contributor.authorLequin, M.en
dc.contributor.authorBreuillard, D.en
dc.contributor.authorBoddaert, N.en
dc.contributor.authorJozwiak, S.en
dc.contributor.authorKotulska, K.en
dc.contributor.authorRiney, K.en
dc.contributor.authorFeucht, M.en
dc.contributor.authorSamueli, S.en
dc.contributor.authorScholl, T.en
dc.contributor.authorKrsek, P.en
dc.contributor.authorBenova, B.en
dc.contributor.authorBraun, K. P. J.en
dc.contributor.authorJansen, F. E.en
dc.contributor.authorNabbout, R.en
dc.contributor.authorCuratolo, P.en
dc.contributor.authorLagae, L.en
dc.contributor.authorJansen, A.en
dc.contributor.authorAronica, E.en
dc.contributor.authorKwiatkowski, D.en
dc.contributor.authorWeschke, B.en
dc.contributor.authorWojdan, K.en
dc.contributor.authorSijko, K.en
dc.contributor.authorGłowacka, J.en
dc.contributor.authorBorkowska, J.en
dc.contributor.authorSadowski, K.en
dc.contributor.authorDomańska-Pakieła, D.en
dc.contributor.authorAnink, J.en
dc.contributor.authorBenvenuto, A.en
dc.contributor.authorBlazejczyk, M.en
dc.contributor.authorBongaerts, A.en
dc.contributor.authorChmielewski, D.en
dc.contributor.authorDabrowska, M.en
dc.contributor.authorDe Ridder, J.en
dc.contributor.authorGiannikou, K.en
dc.contributor.authorHamieh, L.en
dc.contributor.authorHaręza, A.en
dc.contributor.authorIyer, A.en
dc.contributor.authorJanssen, B.en
dc.contributor.authorJaworski, J.en
dc.date.accessioned2022-11-07T23:37:41Z-
dc.date.available2022-11-07T23:37:41Z-
dc.date.issued2021en
dc.identifier.citation233 , 2021, p. 156-162.e2en
dc.identifier.otherRISen
dc.identifier.urihttp://dora.health.qld.gov.au/qldresearchjspui/handle/1/3015-
dc.description.abstractObjective: To correlate fetal brain magnetic resonance imaging (MRI) findings with epilepsy characteristics and neurodevelopment at 2 years of age in children with tuberous sclerosis complex (TSC) to improve prenatal counseling. Study design: This retrospective cohort study was performed in a collaboration between centers of the EPISTOP consortium. We included children with definite TSC, fetal MRIs, and available follow-up data at 2 years of age. A pediatric neuroradiologist masked to the patient's clinical characteristics evaluated all fetal MRIs. MRIs were categorized for each of the 10 brain lobes as score 0: no (sub)cortical lesions or doubt; score 1: a single small lesion; score 2: more than one small lesion or at least one large lesion (>5 mm). Neurologic manifestations were correlated to lesion sum scores. Results: Forty-one children were included. Median gestational age at MRI was 33.3 weeks; (sub)cortical lesions were detected in 97.6%. Mean lesion sum score was 4.5. At 2 years, 58.5% of patients had epilepsy and 22% had drug-resistant epilepsy. Cognitive, language, and motor development were delayed in 38%, 81%, and 50% of patients, respectively. Autism spectrum disorder (ASD) was diagnosed in 20.5%. Fetal MRI lesion sum scores were significantly associated with cognitive and motor development, and with ASD diagnosis, but not with epilepsy characteristics. Conclusions: Fetal cerebral lesion scores correlate with neurodevelopment and ASD at 2 years in children with TSC.L20115786872021-04-12 <br />2021-07-13 <br />en
dc.language.isoenen
dc.relation.ispartofJournal of Pediatricsen
dc.titleFetal Brain Magnetic Resonance Imaging Findings Predict Neurodevelopment in Children with Tuberous Sclerosis Complexen
dc.typeArticleen
dc.identifier.doi10.1016/j.jpeds.2021.02.060en
dc.subject.keywordsretrospective studyen
dc.subject.keywordsarticleautismen
dc.subject.keywordsbrain cortex lesionen
dc.subject.keywordschilden
dc.subject.keywordsclinical featureen
dc.subject.keywordscognitive developmenten
dc.subject.keywordscohort analysisen
dc.subject.keywordsepilepsyen
dc.subject.keywordsfetusen
dc.subject.keywordsfetus brainen
dc.subject.keywordsfollow upen
dc.subject.keywordsgestational ageen
dc.subject.keywordshumanen
dc.subject.keywordslanguage developmenten
dc.subject.keywordsmajor clinical studyen
dc.subject.keywordsmotor developmenten
dc.subject.keywordsnervous system developmenten
dc.subject.keywordsnuclear magnetic resonance imagingen
dc.subject.keywordspreschool childen
dc.subject.keywordstuberous sclerosisen
dc.subject.keywordspriority journalen
dc.relation.urlhttps://www.embase.com/search/results?subaction=viewrecord&id=L2011578687&from=exporthttp://dx.doi.org/10.1016/j.jpeds.2021.02.060 |en
dc.identifier.risid2649en
dc.description.pages156-162.e2en
item.grantfulltextnone-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Sites:Children's Health Queensland Publications
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