Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/2063
Title: Bacterial colonization dynamics associated with respiratory syncytial virus during early childhood
Authors: Sly, P. D.
Grimwood, K.
Chappell, K. J.
Brealey, J. C.
Young, P. R.
Sloots, T. P.
Ware, R. S.
Lambert, S. B.
Issue Date: 2020
Source: 55, (5), 2020, p. 1237-1245
Pages: 1237-1245
Journal: Pediatric Pulmonology
Abstract: Respiratory syncytial virus (RSV) is an important cause of early life acute respiratory infections. Potentially pathogenic respiratory bacteria, including Streptococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae are frequently detected during RSV infections and associated with increased illness severity. However, the temporal dynamics of bacterial colonization associated with RSV infection remain unclear. We used weekly nasal swab data from a prospective longitudinal birth cohort in Brisbane, Australia, to investigate bacterial colonization patterns within children aged less than 2 years in the 4-week period before and after an RSV infection. During 54 RSV infection episodes recorded in 47 children, both S. pneumoniae and M. catarrhalis were detected frequently (in 33 [61.1%] and 26 [48.1%] RSV infections, respectively). In most cases, S. pneumoniae and M. catarrhalis colonization preceded the viral infection, with the nasal load of each increasing during RSV infection. Generally, the dominant serotype of S. pneumoniae remained consistent in the 1 to 2 weeks immediately before and after RSV infection. Little evidence was found to indicate that prior colonization with either bacteria predisposed participants to developing RSV infection during the annual seasonal epidemic. Possible coacquisition events, where the bacteria species was first detected with RSV and not in the preceding 4 weeks, were observed in approximately 20% of RSV/S. pneumoniae and RSV/M. catarrhalis codetections. Taken together our results indicate that RSV generally triggered an outgrowth, rather than a new acquisition, of S. pneumoniae and M. catarrhalis from the resident microbial community.L20044360262020-03-24
DOI: 10.1002/ppul.24715
Resources: https://www.embase.com/search/results?subaction=viewrecord&id=L2004436026&from=exporthttp://dx.doi.org/10.1002/ppul.24715 |
Keywords: nonhuman;nose smear;priority journal;respiratory syncytial virus infection;serotype;Streptococcus pneumoniae;virus load;prospective study;articleAustralia;bacterial colonization;bacterial growth;bacterium detection;bacterium identification;childhood;cohort analysis;controlled study;disease association;disease course;disease duration;disease predisposition;epidemic;evidence based practice;human;longitudinal study;major clinical study;microbial community;Moraxella catarrhalis;newborn
Type: Article
Appears in Sites:Children's Health Queensland Publications

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