Please use this identifier to cite or link to this item:
https://dora.health.qld.gov.au/qldresearchjspui/handle/1/2062
Title: | Bacteria and viruses in the nasopharynx immediately prior to onset of acute lower respiratory infections in Indigenous Australian children | Authors: | Leach, A. J. MacHunter, B. Chatfield, M. D. Sloots, T. P. Cheng, A. C. Smith-Vaughan, H. C. Binks, M. J. Beissbarth, J. Chang, Anne McCallum, G. B. Mackay, I. M. Morris, P. S. Marsh, R. L. Torzillo, P. J. Wurzel, D. F. Grimwood, K. Nosworthy, E. Gaydon, J. E. |
Issue Date: | 2018 | Source: | 37, (9), 2018, p. 1785-1794 | Pages: | 1785-1794 | Journal: | European Journal of Clinical Microbiology and Infectious Diseases | Abstract: | Acute lower respiratory infection (ALRI) is a major cause of hospitalization for Indigenous children in remote regions of Australia. The associated microbiology remains unclear. Our aim was to determine whether the microbes present in the nasopharynx before an ALRI were associated with its onset. A retrospective case-control/crossover study among Indigenous children aged up to 2 years. ALRI cases identified by medical note review were eligible where nasopharyngeal swabs were available: (1) 0–21 days before ALRI onset (case); (2) 90–180 days before ALRI onset (same child controls); and (3) from time and age-matched children without ALRI (different child controls). PCR assays determined the presence and/or load of selected respiratory pathogens. Among 104 children (182 recorded ALRI episodes), 120 case-same child control and 170 case-different child control swab pairs were identified. Human adenoviruses (HAdV) were more prevalent in cases compared to same child controls (18 vs 7%; OR = 3.08, 95% CI 1.22–7.76, p = 0.017), but this association was not significant in cases versus different child controls (15 vs 10%; OR = 1.93, 95% CI 0.97–3.87 (p = 0.063). No other microbes were more prevalent in cases compared to controls. Streptococcus pneumoniae (74%), Haemophilus influenzae (75%) and Moraxella catarrhalis (88%) were commonly identified across all swabs. In a pediatric population with a high detection rate of nasopharyngeal microbes, HAdV was the only pathogen detected in the period before illness presentation that was significantly associated with ALRI onset. Detection of other potential ALRI pathogens was similar between cases and controls.L6227997892018-07-04 | DOI: | 10.1007/s10096-018-3314-7 | Resources: | https://www.embase.com/search/results?subaction=viewrecord&id=L622799789&from=exporthttp://dx.doi.org/10.1007/s10096-018-3314-7 | | Keywords: | human;human adenovirus infection;Human bocavirus;Human metapneumovirus;Human respiratory syncytial virus;Human rhinovirus;Indigenous Australian;infant;wheezing;Influenza virus;lower respiratory tract infection;lung auscultation;lung infiltrate;male;medical record review;Moraxella catarrhalis;Mycoplasma pneumoniae;nasopharynx;nose smear;Paramyxovirinae;polymerase chain reaction;Polyomavirus;priority journal;retrospective study;Staphylococcus aureus;Streptococcus pneumoniae;thorax radiography;virus detection;virus infection;articlebacterial infection;bacterium detection;breathing rate;case control study;child;Chlamydia pneumoniae;controlled study;crackle;crossover procedure;female;Haemophilus influenzae | Type: | Article |
Appears in Sites: | Children's Health Queensland Publications |
Show full item record
Items in DORA are protected by copyright, with all rights reserved, unless otherwise indicated.