Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/1855
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSafa, H.en
dc.contributor.authorGriffin, P.en
dc.contributor.authorNourse, C.en
dc.contributor.authorWu, M.en
dc.contributor.authorSeel, M.en
dc.contributor.authorBritton, S.en
dc.contributor.authorDean, J. A.en
dc.contributor.authorLazarou, M.en
dc.date.accessioned2022-11-07T23:25:04Z-
dc.date.available2022-11-07T23:25:04Z-
dc.date.issued2022en
dc.identifier.citation62, (1), 2022, p. 91-97en
dc.identifier.otherRISen
dc.identifier.urihttp://dora.health.qld.gov.au/qldresearchjspui/handle/1/1855-
dc.description.abstractBackground: Syphilis in pregnancy and congenital syphilis (CS) are increasing in Australia. Prevention of adverse outcomes requires adherence to management guidelines. Aims: The aim is to evaluate the management of syphilis in pregnant women and their newborns. Materials and Methods: A retrospective study of public health notifications, clinical records and testing results of women with positive syphilis serology in pregnancy requiring treatment from 2016 to 2018 inclusive across South-East Queensland was conducted. Management was described and compared with contemporary guidelines from the Australasian Society of Infectious Diseases, the Communicable Diseases Network Australia and the United States Centers for Disease Control and Prevention. Results: Of 30 women identified, 22 (73%) had management consistent with the guidelines (stage-appropriate penicillin regimen, appropriate dosing interval and treatment completed greater than 30 days before delivery). Only 14 (47%) women had documentation of partner testing and/or treatment. Of 26 mother–infant pairs with complete data, 16 (62%) had investigations at delivery consistent with recommendations (parallel maternal–infant rapid plasma reagin, infant syphilis immunoglobulin M, placental histopathology +/– syphilis polymerase chain reaction and infant clinical examination). One infant met the criteria for confirmed CS. Five infants received penicillin therapy. Only seven (27%) infants had serological monitoring after discharge. Conclusions: Management can be optimised with timely maternal testing and treatment, comprehensive partner screening and treatment, strict adherence to seven-day penicillin dosing for late latent syphilis and thorough maternal and infant testing after treatment and delivery. If maternal treatment was inadequate in pregnancy, consideration needs to be given to close evaluation and empiric treatment of the infant.L20135810542021-09-03 <br />2022-04-26 <br />en
dc.language.isoenen
dc.relation.ispartofAustralian and New Zealand Journal of Obstetrics and Gynaecologyen
dc.titleAddressing the crisis of congenital syphilis: Key findings from an evaluation of the management of syphilis in pregnancy and the newborn in South-East Queenslanden
dc.typeArticleen
dc.identifier.doi10.1111/ajo.13424en
dc.subject.keywordsgestational ageen
dc.subject.keywordshistopathologyen
dc.subject.keywordshospital dischargeen
dc.subject.keywordshumanen
dc.subject.keywordshuman tissueen
dc.subject.keywordslatent syphilisen
dc.subject.keywordslive birthen
dc.subject.keywordslong boneen
dc.subject.keywordsmajor clinical studyen
dc.subject.keywordsmaleen
dc.subject.keywordsmaternal careen
dc.subject.keywordsmaternal treatmenten
dc.subject.keywordsmedical record reviewen
dc.subject.keywordsmedication complianceen
dc.subject.keywordsmultiple cycle treatmenten
dc.subject.keywordsnewbornen
dc.subject.keywordsnewborn careen
dc.subject.keywordsobstetric deliveryen
dc.subject.keywordsparityen
dc.subject.keywordspatient history of therapyen
dc.subject.keywordspatient monitoringen
dc.subject.keywordsplacenta tissueen
dc.subject.keywordspolymerase chain reactionen
dc.subject.keywordspregnancyen
dc.subject.keywordspremature laboren
dc.subject.keywordsprotocol complianceen
dc.subject.keywordsreinfectionen
dc.subject.keywordsrescreeningen
dc.subject.keywordsretreatmenten
dc.subject.keywordsretrospective studyen
dc.subject.keywordssingle drug doseen
dc.subject.keywordsspontaneous abortionen
dc.subject.keywordssyphilis serologyen
dc.subject.keywordsthird trimester pregnancyen
dc.subject.keywordstime to treatmenten
dc.subject.keywordstreatment refusalen
dc.subject.keywordsvenereal disease reaction testen
dc.subject.keywordstreatment durationen
dc.subject.keywordsbenzathine penicillinimmunoglobulin Men
dc.subject.keywordspenicillin Gen
dc.subject.keywordsreaginic antibodyen
dc.subject.keywordsantibiotic therapyen
dc.subject.keywordsantibody blood levelen
dc.subject.keywordsarticleen
dc.subject.keywordsbirth weighten
dc.subject.keywordsblood analysisen
dc.subject.keywordsbone radiographyen
dc.subject.keywordscerebrospinal fluid analysisen
dc.subject.keywordsclinical examinationen
dc.subject.keywordsclinical pathwayen
dc.subject.keywordscongenital malformationen
dc.subject.keywordscongenital syphilisen
dc.subject.keywordsdesensitizationen
dc.subject.keywordsdiagnosis timeen
dc.subject.keywordsdose calculationen
dc.subject.keywordsfalse positive resulten
dc.subject.keywordsfemaleen
dc.subject.keywordsfollow upen
dc.relation.urlhttps://www.embase.com/search/results?subaction=viewrecord&id=L2013581054&from=exporthttp://dx.doi.org/10.1111/ajo.13424 |en
dc.identifier.risid531en
dc.description.pages91-97en
item.grantfulltextnone-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Sites:Children's Health Queensland Publications
Show simple item record

Page view(s)

44
checked on Apr 22, 2025

Google ScholarTM

Check

Altmetric


Items in DORA are protected by copyright, with all rights reserved, unless otherwise indicated.