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https://dora.health.qld.gov.au/qldresearchjspui/handle/1/1835
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DC Field | Value | Language |
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dc.contributor.author | Aebi, C. | en |
dc.contributor.author | Schlapbach, L. J. | en |
dc.contributor.author | Berger, C. | en |
dc.contributor.author | Agyeman, P. K. A. | en |
dc.contributor.author | Endrich, O. | en |
dc.contributor.author | Triep, K. | en |
dc.contributor.author | Posfay-Barbe, K. M. | en |
dc.contributor.author | Heininger, U. | en |
dc.contributor.author | Bern-hard-Stirnemann, S. | en |
dc.contributor.author | Giannoni, E. | en |
dc.contributor.author | Stocker, M. | en |
dc.contributor.author | Niederer-Loher, A. | en |
dc.contributor.author | Kahlert, C. | en |
dc.contributor.author | Natalucci, G. | en |
dc.contributor.author | Riedel, T. | en |
dc.contributor.author | Relly, C. | en |
dc.date.accessioned | 2022-11-07T23:24:49Z | - |
dc.date.available | 2022-11-07T23:24:49Z | - |
dc.date.issued | 2019 | en |
dc.identifier.citation | 149 , 2019, p. 19S | en |
dc.identifier.other | RIS | en |
dc.identifier.uri | http://dora.health.qld.gov.au/qldresearchjspui/handle/1/1835 | - |
dc.description.abstract | Background: The recent resolution on sepsis by the World Health Or-ganization urges member states to better characterize the burden of sep-sis. Sepsis coding based on the International Statistical Classification of Diseases and Related Health Problems (ICD-10) is widely used, how-ever, there is a lack of paediatric data assessing accuracy of ICD-10 sepsis coding. In addition, the recent change in sepsis definitions implies a need for reliable coding of organ dysfunctions. We analysed accuracy of sepsis diagnosis based on ICD-10 codes in a prospective cohort of children with sepsis. Methods: We performed a multicentre, prospective cohort study at ten paediatric hospitals in Switzerland from 01.09.2011 to 31.12.2015, re-cruiting children younger than 17 years with blood culture-proven sepsis. For this analyses, we excluded prematurely born neonates and infants less than 7 days old at sepsis onset. We used 2005 consensus defini-tions - based on prospectively collected clinical and laboratory data - as the reference standard to define sepsis and organ dysfunctions. ICD-10 codes were extracted from mandatory official hospital discharge data re-lated to the sepsis episodes at 8 study sites. Results: Of 679 episodes with blood culture-proven sepsis recruited in the participating hospitals, 455 (67%) were classified as sepsis by ICD-10 codes. 305 (45%) had at least one organ dysfunction according to 2005 consensus criteria and 249 (37%) according to ICD-10 codes; the accuracy of ICD-10 codes for organ dysfunction was 69%, sensitivity 56%, and specificity 79%. In 163 (24%) episodes multi-organ dysfunction syndrome (MODS) was present as per 2005 consensus criteria and in 98 (14%) with ICD-10 codes; the accuracy of ICD-10 codes for MODS was 64%, sensitivity 39%, and specificity 93%. Sensitivity of ICD-10 codes was especially poor for central nervous system (6%), hepatic (7%), respiratory (26%), and hematological dysfunction (30%), and only fair for renal (45%) and cardiac dysfunction (48%). Conclusion: Compared to the reference standard, ICD-10 codes under-estimated incidence of sepsis, organ dysfunctions, and MODS and did not reliably depict organ dysfunctions in children with blood culture-proven sepsis.L6287264032019-08-05 <br /> | en |
dc.language.iso | en | en |
dc.relation.ispartof | Swiss Medical Weekly | en |
dc.title | Accuracy of ICD-10 coding for sepsis and organ dysfunctions in children with blood culture-proven sepsis in Switzerland, results from the prospective Swiss Pediatric Sepsis Study | en |
dc.type | Article | en |
dc.subject.keywords | Switzerland | en |
dc.subject.keywords | blood culturecentral nervous system | en |
dc.subject.keywords | child | en |
dc.subject.keywords | cohort analysis | en |
dc.subject.keywords | conference abstract | en |
dc.subject.keywords | consensus | en |
dc.subject.keywords | controlled study | en |
dc.subject.keywords | female | en |
dc.subject.keywords | heart disease | en |
dc.subject.keywords | hematologic disease | en |
dc.subject.keywords | hospital discharge | en |
dc.subject.keywords | human | en |
dc.subject.keywords | ICD-10 | en |
dc.subject.keywords | incidence | en |
dc.subject.keywords | kidney | en |
dc.subject.keywords | liver | en |
dc.subject.keywords | major clinical study | en |
dc.subject.keywords | male | en |
dc.subject.keywords | multicenter study | en |
dc.subject.keywords | multiple organ failure | en |
dc.subject.keywords | newborn | en |
dc.subject.keywords | pediatric hospital | en |
dc.subject.keywords | prospective study | en |
dc.subject.keywords | respiratory system | en |
dc.subject.keywords | sensitivity and specificity | en |
dc.subject.keywords | sepsis | en |
dc.relation.url | https://www.embase.com/search/results?subaction=viewrecord&id=L628726403&from=export | en |
dc.identifier.risid | 2218 | en |
dc.description.pages | 19S | en |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
Appears in Sites: | Children's Health Queensland Publications |
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