Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/1432
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dc.contributor.authorBarnden, Leighton Ren_US
dc.contributor.authorShan, Zack Yen_US
dc.contributor.authorStaines, Donald Ren_US
dc.contributor.authorMarshall-Gradisnik, Sonyaen_US
dc.contributor.authorFinegan, Kevinen_US
dc.contributor.authorIreland, Timothyen_US
dc.contributor.authorBhuta, Sandeepen_US
dc.date.accessioned2021-08-17T05:55:13Z-
dc.date.available2021-08-17T05:55:13Z-
dc.date.issued2019-10-
dc.identifier.citationBarnden LR, Shan ZY, Staines DR, Marshall-Gradisnik S, Finegan K, Ireland T, Bhuta S. Intra brainstem connectivity is impaired in chronic fatigue syndrome. Neuroimage Clin. 2019;24:102045. doi: 10.1016/j.nicl.2019.102045en_US
dc.identifier.urihttp://dora.health.qld.gov.au/qldresearchjspui/handle/1/1432-
dc.description.abstractIn myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), abnormal MRI correlations with symptom severity and autonomic measures have suggested impaired nerve signal conduction within the brainstem. Here we analyse fMRI correlations to directly test connectivity within and from the brainstem. Resting and task functional MRI (fMRI) were acquired for 45 ME/CFS (Fukuda criteria) and 27 healthy controls (HC). We selected limited brainstem reticular activation system (RAS) regions-of-interest (ROIs) based on previous structural MRI findings in a different ME/CFS cohort (bilateral rostral medulla and midbrain cuneiform nucleus), the dorsal Raphe nucleus, and two subcortical ROIs (hippocampus subiculum and thalamus intralaminar nucleus) reported to have rich brainstem connections. When HC and ME/CFS were analysed separately, significant correlations were detected for both groups during both rest and task, with stronger correlations during task than rest. In ME/CFS, connections were absent between medulla and midbrain nuclei, although hippocampal connections with these nuclei were enhanced. When corresponding correlations from HC and ME/CFS were compared, ME/CFS connectivity deficits were detected within the brainstem between the medulla and cuneiform nucleus and between the brainstem and hippocampus and intralaminar thalamus, but only during task. In CFS/ME, weaker connectivity between some RAS nuclei was associated with increased symptom severity. RAS neuron oscillatory signals facilitate coherence in thalamo-cortical oscillations. Brainstem RAS connectivity deficits can explain autonomic changes and diminish cortical oscillatory coherence which can impair attention, memory, cognitive function, sleep quality and muscle tone, all symptoms of ME/CFS.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofNeuroImage. Clinicalen_US
dc.subjectChronic fatigue syndromeen_US
dc.subjectBrain Stemen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectConnectivityen_US
dc.subjectCuneiform nucleusen_US
dc.titleIntra brainstem connectivity is impaired in chronic fatigue syndromeen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.nicl.2019.102045-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Sites:Gold Coast Health Publications
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