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|Title:||Towards a Universal Molecular Microbiological Test||Authors:||Allcock, Richard J N
Jennison, Amy V
|Issue Date:||2017||Publisher:||American Society for Microbiology||Source:||J Clin Microbiol. 2017 Nov;55(11):3175-3182. doi: 10.1128/JCM.01155-17. Epub 2017 Aug 23.||Journal:||Journal of clinical microbiology||Abstract:||The standard paradigm for microbiological testing is dependent on the presentation of a patient to a clinician. Tests are then requested based on differential diagnoses using the patient's symptoms as a guide. The era of high-throughput genomic methods has the potential to replace this model for the first time with what could be referred to as "hypothesis-free testing." This approach utilizes one of a variety of methodologies to obtain a sequence from potentially any nucleic acid in a clinical sample, without prior knowledge of its content. We discuss the advantages of such an approach and the challenges in making this a reality.||DOI:||10.1128/jcm.01155-17||Keywords:||communicable disease;molecular diagnosis||Type:||Article|
|Appears in Sites:||Forensic and Scientific Services|
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