Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/7534
Title: Shear-wave elastography for monitoring Fontan-associated liver disease: A prospective cohort study
Authors: Bolia, Rishi
Alremawi, Sara
Noble, Charlton
Justo, Robert 
Ward, Cameron 
Lewindon, Peter J.
Issue Date: 2024
Source: Journal of pediatric gastroenterology and nutrition, 2024 (79) 1 p.126-130
Pages: 126-130
Journal Title: Journal of pediatric gastroenterology and nutrition
Abstract: The spectrum of Fontan-associated liver disease (FALD) varies from abnormal liver function tests to fibrosis and even cirrhosis. In this prospective study, we evaluated the role of shear-wave elastography (SWE) in predicting the presence of advanced FALD. Forty-eight patients (30 males, 13.9 [6-21] years) with a Fontan circulation were evaluated at 8.3 (2.1-18.7) years since the Fontan surgery. The median liver stiffness measurement (LSM) value was higher than values in normal children at 15.4 (9.5-38.7) kPa. The LSMs had a weak but significant correlation with age at the time of LSM (r = 0.25, p = 0.01) and duration post-Fontan surgery (r = 0.31, p = 0.02). It had a poor correlation with the concomitant aspartate transaminase-to-platelet ratio index (r = 0.1, p = 0.39). No difference in the elastography values between children with and without ultrasound evidence of advanced liver disease (17.7 [interquartile range, IQR: 4] vs. 16.1 [IQR: 6], p = 0.62] was observed. Further studies are required to determine the precise role of SWE as a noninvasive marker of liver fibrosis in FALD. (© 2024 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.)
DOI: 10.1002/jpn3.12182
Resources: https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,athens&db=mdc&AN=38477364&site=ehost-live
Appears in Sites:Children's Health Queensland Publications
Queensland Health Publications

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