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Title: | Shear-wave elastography for monitoring Fontan-associated liver disease: A prospective cohort study | Authors: | Bolia, Rishi Alremawi, Sara Noble, Charlton Justo, Robert Ward, Cameron Lewindon, Peter J. |
Issue Date: | 2024 | Source: | Journal of pediatric gastroenterology and nutrition, 2024 (79) 1 p.126-130 | Pages: | 126-130 | Journal Title: | Journal of pediatric gastroenterology and nutrition | Abstract: | The spectrum of Fontan-associated liver disease (FALD) varies from abnormal liver function tests to fibrosis and even cirrhosis. In this prospective study, we evaluated the role of shear-wave elastography (SWE) in predicting the presence of advanced FALD. Forty-eight patients (30 males, 13.9 [6-21] years) with a Fontan circulation were evaluated at 8.3 (2.1-18.7) years since the Fontan surgery. The median liver stiffness measurement (LSM) value was higher than values in normal children at 15.4 (9.5-38.7) kPa. The LSMs had a weak but significant correlation with age at the time of LSM (r = 0.25, p = 0.01) and duration post-Fontan surgery (r = 0.31, p = 0.02). It had a poor correlation with the concomitant aspartate transaminase-to-platelet ratio index (r = 0.1, p = 0.39). No difference in the elastography values between children with and without ultrasound evidence of advanced liver disease (17.7 [interquartile range, IQR: 4] vs. 16.1 [IQR: 6], p = 0.62] was observed. Further studies are required to determine the precise role of SWE as a noninvasive marker of liver fibrosis in FALD. (© 2024 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.) | DOI: | 10.1002/jpn3.12182 | Resources: | https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,athens&db=mdc&AN=38477364&site=ehost-live |
Appears in Sites: | Children's Health Queensland Publications Queensland Health Publications |
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