Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/7049
Title: Synchronous intracranial arteriovenous malformation and papillary glioneuronal tumour: hypothesis or reality?
Authors: Stuart, Michael
Burnett, Adam
Robertson, Thomas
Harbison, Annabelle
Coulthard, Liam 
Campbell, Robert
Issue Date: 2024
Source: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2024 (40) 12 p.4329-4333
Pages: 4329-4333
Journal Title: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Abstract: Brain arteriovenous malformations (AVM) rarely occur with spatial and/or temporal co-localisation to intracranial neoplasms. Most prior reports describe this association with high-grade gliomas; however, reports of a co-occurrence with low grade gliomas are very rare. It is unclear whether such cases represent a true co-occurrence of separate pathologies or simply an unusually vascular phenotype of the neoplasm. Most such reports pre-date the era of molecularly defined gliomas. We present the first report of the spatial and temporal co-occurrence of an intracranial arteriovenous malformation traversing and within a papillary glioneuronal tumour, molecularly defined by the presence of SLC44A1::PRKCA fusion. This case was successfully managed by resection of both lesions adhering to the principles of AVM surgery. It is possible these exceptionally rare co-occurrences may have common underlying molecular drivers relating to the mitogen activated protein kinase (MAPK) pathway.; Competing Interests: Declarations. Conflict of interest: The authors declare no competing interests. (© 2024. The Author(s).)
DOI: 10.1007/s00381-024-06621-3
Resources: https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,athens&db=mdc&AN=39292231&site=ehost-live
Appears in Sites:Children's Health Queensland Publications
Queensland Health Publications

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