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Title: | Synchronous intracranial arteriovenous malformation and papillary glioneuronal tumour: hypothesis or reality? | Authors: | Stuart, Michael Burnett, Adam Robertson, Thomas Harbison, Annabelle Coulthard, Liam Campbell, Robert |
Issue Date: | 2024 | Source: | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2024 (40) 12 p.4329-4333 | Pages: | 4329-4333 | Journal Title: | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery | Abstract: | Brain arteriovenous malformations (AVM) rarely occur with spatial and/or temporal co-localisation to intracranial neoplasms. Most prior reports describe this association with high-grade gliomas; however, reports of a co-occurrence with low grade gliomas are very rare. It is unclear whether such cases represent a true co-occurrence of separate pathologies or simply an unusually vascular phenotype of the neoplasm. Most such reports pre-date the era of molecularly defined gliomas. We present the first report of the spatial and temporal co-occurrence of an intracranial arteriovenous malformation traversing and within a papillary glioneuronal tumour, molecularly defined by the presence of SLC44A1::PRKCA fusion. This case was successfully managed by resection of both lesions adhering to the principles of AVM surgery. It is possible these exceptionally rare co-occurrences may have common underlying molecular drivers relating to the mitogen activated protein kinase (MAPK) pathway.; Competing Interests: Declarations. Conflict of interest: The authors declare no competing interests. (© 2024. The Author(s).) | DOI: | 10.1007/s00381-024-06621-3 | Resources: | https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,athens&db=mdc&AN=39292231&site=ehost-live |
Appears in Sites: | Children's Health Queensland Publications Queensland Health Publications |
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