Please use this identifier to cite or link to this item:
https://dora.health.qld.gov.au/qldresearchjspui/handle/1/5602
Title: | A genome-wide association study of total child psychiatric problems scores | Authors: | Neumann, Alexander Nolte, Ilja M Pappa, Irene Ahluwalia, Tarunveer S Pettersson, Erik Rodriguez, Alina Whitehouse, Andrew van Beijsterveldt, Catharina E M Benyamin, Beben Hammerschlag, Anke R Helmer, Quinta Karhunen, Ville Krapohl, Eva Lu, Yi van der Most, Peter J Palviainen, Teemu St Pourcain, Beate Seppälä, Ilkka Suarez, Anna Vilor-Tejedor, Natalia Tiesler, Carla M T Wang, Carol Wills, Amanda Zhou, Ang Alemany, Silvia Bisgaard, Hans Bønnelykke, Klaus Davies, Gareth E Hakulinen, Christian Henders, Anjali K Hyppönen, Elina Stokholm, Jakob Bartels, Meike Hottenga, Jouke-Jan Heinrich, Joachim Hewitt, John Keltikangas-Järvinen, Liisa Korhonen, Tellervo Kaprio, Jaakko Lahti, Jari Lahti-Pulkkinen, Marius Lehtimäki, Terho Middeldorp, Christel Najman, Jackob M Pennell, Craig Power, Chris Oldehinkel, Albertine J Plomin, Robert Räikkönen, Katri Raitakari, Olli T Rimfeld, Kaili Sass, Lærke Snieder, Harold Standl, Marie Sunyer, Jordi Williams, Gail M Bakermans-Kranenburg, Marian J Boomsma, Dorret I van IJzendoorn, Marinus H Hartman, Catharina A Tiemeier, Henning |
Issue Date: | 2022 | Journal: | PloS one | Abstract: | Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EAGLE consortium. The SNP heritability of total psychiatric problems was 5.4% (SE = 0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of SBF2, a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total score were shared with common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (rG > 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (rG < 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation with intelligence, educational attainment, wellbeing, smoking, and body fat (rG > 0.29). The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between related traits. | DOI: | 10.1371/journal.pone.0273116 | Type: | Article |
Appears in Sites: | Children's Health Queensland Publications |
Show full item record
Items in DORA are protected by copyright, with all rights reserved, unless otherwise indicated.