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https://dora.health.qld.gov.au/qldresearchjspui/handle/1/5308| Title: | Anti-TNFα therapy in IBD alters brain activity reflecting visceral sensory function and cognitive-affective biases | Authors: | Gray, Marcus A Chao, Che-Yung Staudacher, Heidi M Kolosky, Natasha A Talley, Nicholas J Holtmann, Gerald |
Issue Date: | 2018 | Journal: | PloS one | Abstract: | In inflammatory bowel disease (IBD), immune activation with increased circulating TNF-α is linked to the intensity of gastrointestinal symptoms and depression or anxiety. A central feature of depression is cognitive biases linked to negative attributions about self, the world and the future. We aimed to assess the effects of anti-TNFα therapy on the central processing of self-attribution biases and visceral afferent information in patients with Crohn's disease. | DOI: | 10.1371/journal.pone.0193542 | metadata.dc.rights.holder: | Holtmann, Gerald | Type: | Article |
| Appears in Sites: | Gastroenterology and Hepatology, Princess Alexandra Hospital |
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