Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/5069
Title: Women with type 1 diabetes exhibit a progressive increase in gut Saccharomyces cerevisiae in pregnancy associated with evidence of gut inflammation
Authors: Harris, Mark 
Penno, Megan A. S.
Bediaga, Naiara G.
Naselli, Gaetano
Ngui, Katrina M.
Smith, Alannah D.
Huang, Dexing
Zozaya-Valdes, Enrique
Thomson, Rebecca L.
Brown, James D.
Vuillermin, Peter J.
Barry, Simon C.
Craig, Maria E.
Rawlinson, William D.
Davis, Elizabeth A.
Soldatos, Georgia
Colman, Peter G.
Bandala-Sanchez, Esther
Roth-Schulze, Alexandra J.
Oakey, Helena
Issue Date: 2022
Source: 184 , 2022, p. N.PAG-N.PAG
Pages: N.PAG-N.PAG
Journal: Diabetes Research & Clinical Practice
Abstract: Aims: Studies of the gut microbiome have focused on its bacterial composition. We aimed to characterize the gut fungal microbiome (mycobiome) across pregnancy in women with and without type 1 diabetes.Methods: Faecal samples (n = 162) were collected from 70 pregnant women (45 with and 25 without type 1 diabetes) across all trimesters. Fungi were analysed by internal transcribed spacer 1 amplicon sequencing. Markers of intestinal inflammation (faecal calprotectin) and intestinal epithelial integrity (serum intestinal fatty acid binding protein; I-FABP), and serum antibodies to Saccharomyces cerevisiae (ASCA) were measured.Results: Women with type 1 diabetes had decreased fungal alpha diversity by the third trimester, associated with an increased abundance of Saccharomyces cerevisiae that was inversely related to the abundance of the anti-inflammatory butyrate-producing bacterium Faecalibacterium prausnitzii. Women with type 1 diabetes had higher concentrations of calprotectin, I-FABP and ASCA.Conclusions: Women with type 1 diabetes exhibit a shift in the gut mycobiome across pregnancy associated with evidence of gut inflammation and impaired intestinal barrier function. The relevance of these findings to the higher rate of pregnancy complications in type 1 diabetes warrants further study.Continental Europe; Editorial Board Reviewed; Europe; Expert Peer Reviewed; Peer Reviewed. NLM UID: 8508335.PMID: NLM35051423.
DOI: 10.1016/j.diabres.2022.109189
Resources: https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,athens&db=ccm&AN=155628730&site=ehost-live
Type: Article
Appears in Sites:Children's Health Queensland Publications

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