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Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/4104
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dc.contributor.authorPedersen, N. L.en
dc.contributor.authorDePaulo, J. R.en
dc.contributor.authorDomenici, E.en
dc.contributor.authorDomschke, K.en
dc.contributor.authorEsko, T.en
dc.contributor.authorGrabe, H. J.en
dc.contributor.authorHamilton, S. P.en
dc.contributor.authorHayward, C.en
dc.contributor.authorHeath, A. C.en
dc.contributor.authorKendler, K. S.en
dc.contributor.authorKloiber, S.en
dc.contributor.authorHerms, S.en
dc.contributor.authorHickie, I. B.en
dc.contributor.authorHoffmann, P.en
dc.contributor.authorHomuth, G.en
dc.contributor.authorHorn, C.en
dc.contributor.authorHottenga, J. J.en
dc.contributor.authorHougaard, D. M.en
dc.contributor.authorIsing, M.en
dc.contributor.authorJansen, R.en
dc.contributor.authorJones, I.en
dc.contributor.authorLewis, G.en
dc.contributor.authorJones, L. A.en
dc.contributor.authorJorgenson, E.en
dc.contributor.authorKnowles, J. A.en
dc.contributor.authorKohane, I. S.en
dc.contributor.authorKraft, J.en
dc.contributor.authorKretzschmar, W. W.en
dc.contributor.authorKutalik, Z.en
dc.contributor.authorLi, Y.en
dc.contributor.authorLind, P. A.en
dc.contributor.authorMacIntyre, D. J.en
dc.contributor.authorLi, Q. S.en
dc.contributor.authorMacKinnon, D. F.en
dc.contributor.authorMaier, R. M.en
dc.contributor.authorMaier, W.en
dc.contributor.authorMarchini, J.en
dc.contributor.authorMbarek, H.en
dc.contributor.authorMcGrath, P.en
dc.contributor.authorMcGuffin, P.en
dc.contributor.authorMedland, S. E.en
dc.contributor.authorMehta, D.en
dc.contributor.authorMiddeldorp, C. M.en
dc.contributor.authorLucae, S.en
dc.contributor.authorMihailov, E.en
dc.contributor.authorMilaneschi, Y.en
dc.contributor.authorMilani, L.en
dc.contributor.authorMondimore, F. M.en
dc.contributor.authorMontgomery, G. W.en
dc.contributor.authorMostafavi, S.en
dc.contributor.authorMullins, N.en
dc.contributor.authorNauck, M.en
dc.contributor.authorNg, B.en
dc.contributor.authorNivard, M. G.en
dc.contributor.authorMadden, P. A. F.en
dc.contributor.authorNyholt, D. R.en
dc.contributor.authorO’Reilly, P. F.en
dc.contributor.authorOskarsson, H.en
dc.contributor.authorOwen, M. J.en
dc.contributor.authorPainter, J. N.en
dc.contributor.authorPedersen, C. B.en
dc.contributor.authorPedersen, M. G.en
dc.contributor.authorPeterson, R. E.en
dc.contributor.authorPettersson, E.en
dc.contributor.authorPeyrot, W. J.en
dc.contributor.authorMagnusson, P. K.en
dc.contributor.authorPistis, G.en
dc.contributor.authorPosthuma, D.en
dc.contributor.authorQuiroz, J. A.en
dc.contributor.authorQvist, P.en
dc.contributor.authorRice, J. P.en
dc.contributor.authorRiley, B. P.en
dc.contributor.authorRivera, M.en
dc.contributor.authorMirza, S. S.en
dc.contributor.authorSchoevers, R.en
dc.contributor.authorSchulte, E. C.en
dc.contributor.authorMartin, N. G.en
dc.contributor.authorShen, L.en
dc.contributor.authorShi, J.en
dc.contributor.authorShyn, S. I.en
dc.contributor.authorSigurdsson, E.en
dc.contributor.authorSinnamon, G. C. B.en
dc.contributor.authorSmit, J. H.en
dc.contributor.authorSmith, D. J.en
dc.contributor.authorStefansson, H.en
dc.contributor.authorSteinberg, S.en
dc.contributor.authorStreit, F.en
dc.contributor.authorMetspalu, A.en
dc.contributor.authorStrohmaier, J.en
dc.contributor.authorTansey, K. E.en
dc.contributor.authorTeismann, H.en
dc.contributor.authorTeumer, A.en
dc.contributor.authorThompson, W.en
dc.contributor.authorThomson, P. A.en
dc.contributor.authorThorgeirsson, T. E.en
dc.contributor.authorTraylor, M.en
dc.contributor.authorTreutlein, J.en
dc.contributor.authorTrubetskoy, V.en
dc.contributor.authorMors, O.en
dc.contributor.authorUitterlinden, A. G.en
dc.contributor.authorUmbricht, D.en
dc.contributor.authorAuwera, S. V.en
dc.contributor.authorvan Hemert, A. M.en
dc.contributor.authorViktorin, A.en
dc.contributor.authorWang, Y.en
dc.contributor.authorWebb, B. T.en
dc.contributor.authorWeinsheimer, S. M.en
dc.contributor.authorWellmann, J.en
dc.contributor.authorWillemsen, G.en
dc.contributor.authorMortensen, P. B.en
dc.contributor.authorWitt, S. H.en
dc.contributor.authorWu, Y.en
dc.contributor.authorXi, H. S.en
dc.contributor.authorYang, J.en
dc.contributor.authorZhang, F.en
dc.contributor.authorArolt, V.en
dc.contributor.authorBaune, B. T.en
dc.contributor.authorBerger, K.en
dc.contributor.authorBoomsma, D. I.en
dc.contributor.authorCichon, S.en
dc.contributor.authorMüller-Myhsok, B.en
dc.contributor.authorDannlowski, U.en
dc.contributor.authorde Geus, E. J. C.en
dc.contributor.authorNordentoft, M.en
dc.contributor.authorNöthen, M. M.en
dc.contributor.authorO’Donovan, M. C.en
dc.contributor.authorPaciga, S. A.en
dc.contributor.authorPenninx, B. W. J. H.en
dc.contributor.authorPerlis, R. H.en
dc.contributor.authorPorteous, D. J.en
dc.contributor.authorPotash, J. B.en
dc.contributor.authorPreisig, M.en
dc.contributor.authorRietschel, M.en
dc.contributor.authorSchaefer, C.en
dc.contributor.authorSchulze, T. G.en
dc.contributor.authorSmoller, J. W.en
dc.contributor.authorStefansson, K.en
dc.contributor.authorTiemeier, H.en
dc.contributor.authorUher, R.en
dc.contributor.authorVölzke, H.en
dc.contributor.authorWeissman, M. M.en
dc.contributor.authorWerge, T.en
dc.contributor.authorLewis, C. M.en
dc.contributor.authorLevinson, D. F.en
dc.contributor.authorBreen, G.en
dc.contributor.authorBørglum, A. D.en
dc.contributor.authorSullivan, P. F.en
dc.contributor.authorWhalley, H. C.en
dc.contributor.authorVisscher, P. M.en
dc.contributor.authorWray, N. R.en
dc.contributor.authorShen, X.en
dc.contributor.authorHoward, D. M.en
dc.contributor.authorAdams, M. J.en
dc.contributor.authorHill, W. D.en
dc.contributor.authorClarke, T. K.en
dc.contributor.authorMcIntosh, A. M.en
dc.contributor.authorDeary, I. J.en
dc.contributor.authorRipke, S.en
dc.contributor.authorMattheisen, M.en
dc.contributor.authorTrzaskowski, M.en
dc.contributor.authorByrne, E. M.en
dc.contributor.authorAbdellaoui, A.en
dc.contributor.authorAgerbo, E.en
dc.contributor.authorAir, T. M.en
dc.contributor.authorAndlauer, T. F. M.en
dc.contributor.authorBacanu, S. A.en
dc.contributor.authorBækvad-Hansen, M.en
dc.contributor.authorBeekman, A. T. F.en
dc.contributor.authorBigdeli, T. B.en
dc.contributor.authorBinder, E. B.en
dc.contributor.authorBryois, J.en
dc.contributor.authorButtenschøn, H. N.en
dc.contributor.authorBybjerg-Grauholm, J.en
dc.contributor.authorCai, N.en
dc.contributor.authorCastelao, E.en
dc.contributor.authorChristensen, J. H.en
dc.contributor.authorColeman, J. R. I.en
dc.contributor.authorColodro-Conde, L.en
dc.contributor.authorCouvy-Duchesne, B.en
dc.contributor.authorCraddock, N.en
dc.contributor.authorCrawford, G. E.en
dc.contributor.authorDavies, G.en
dc.contributor.authorDegenhardt, F.en
dc.contributor.authorDerks, E. M.en
dc.contributor.authorDirek, N.en
dc.contributor.authorDolan, C. V.en
dc.contributor.authorDunn, E. C.en
dc.contributor.authorEley, T. C.en
dc.contributor.authorEscott-Price, V.en
dc.contributor.authorKiadeh, F. F. H.en
dc.contributor.authorFinucane, H. K.en
dc.contributor.authorFoo, J. C.en
dc.contributor.authorForstner, A. J.en
dc.contributor.authorFrank, J.en
dc.contributor.authorGaspar, H. A.en
dc.contributor.authorGill, M.en
dc.contributor.authorGoes, F. S.en
dc.contributor.authorGordon, S. D.en
dc.contributor.authorGrove, J.en
dc.contributor.authorHall, L. S.en
dc.contributor.authorHansen, C. S.en
dc.contributor.authorHansen, T. F.en
dc.date.accessioned2022-11-07T23:49:21Z-
dc.date.available2022-11-07T23:49:21Z-
dc.date.issued2020en
dc.identifier.citation11, (1), 2020en
dc.identifier.otherRISen
dc.identifier.urihttp://dora.health.qld.gov.au/qldresearchjspui/handle/1/4104-
dc.description.abstractDepression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N = 10,674) and replication (N = 11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, in both discovery and replication analyses. Mendelian Randomisation analysis supports a potential causal effect of liability to depression on brain white matter microstructure (β: 0.125 to 0.868, pFDR < 0.043). Several behavioural traits are also associated with depression-PRS (β: 0.014 to 0.180, pFDR: 0.049 to 1.28 × 10−14) and we find a significant and positive interaction between depression-PRS and adverse environmental exposures on mental health outcomes. This study reveals replicable associations between depression-PRS and white matter microstructure. Our results indicate that white matter microstructure differences may be a causal consequence of liability to depression.L20048631902020-05-26 <br />2021-04-06 <br />en
dc.language.isoenen
dc.relation.ispartofNature Communicationsen
dc.titleA phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobanken
dc.typeArticleen
dc.identifier.doi10.1038/s41467-020-16022-0en
dc.subject.keywordshumanen
dc.subject.keywordsinsomniaen
dc.subject.keywordslibrary scienceen
dc.subject.keywordslifestyle and related phenomenaen
dc.subject.keywordsLikert scaleen
dc.subject.keywordsmajor clinical studyen
dc.subject.keywordsmaleen
dc.subject.keywordsmaternal smokingen
dc.subject.keywordsMendelian randomization analysisen
dc.subject.keywordsnuclear magnetic resonance imagingen
dc.subject.keywordsPatient Health Questionnaire 9en
dc.subject.keywordspleiotropyen
dc.subject.keywordspsychiatric genomics consortiumen
dc.subject.keywordsresting state networken
dc.subject.keywordsrisk factoren
dc.subject.keywordsscoring systemen
dc.subject.keywordsUnited Kingdomen
dc.subject.keywordsbirth weighten
dc.subject.keywordsblood pressure measurementen
dc.subject.keywordschildhood traumaen
dc.subject.keywordscognitionen
dc.subject.keywordscontrolled studyen
dc.subject.keywordsdepressionen
dc.subject.keywordseducational statusen
dc.subject.keywordsfemaleen
dc.subject.keywordsgenetic correlationen
dc.subject.keywordsgenetic risk scoreen
dc.subject.keywordsgenome-wide association studyen
dc.subject.keywordshand gripen
dc.subject.keywordshousehold incomeen
dc.subject.keywordsadultarterial stiffnessen
dc.subject.keywordsarticleen
dc.relation.urlhttps://www.embase.com/search/results?subaction=viewrecord&id=L2004863190&from=exporthttp://dx.doi.org/10.1038/s41467-020-16022-0 |en
dc.identifier.risid3021en
local.message.claim2024-06-13T14:03:09.575+1000|||rp04980|||submit_approve|||dc_contributor_author|||None*
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Sites:Children's Health Queensland Publications
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