| Title: | A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank |
Authors: | Pedersen, N. L.
DePaulo, J. R.
Domenici, E.
Domschke, K.
Esko, T.
Grabe, H. J.
Hamilton, S. P.
Hayward, C.
Heath, A. C.
Kendler, K. S.
Kloiber, S.
Herms, S.
Hickie, I. B.
Hoffmann, P.
Homuth, G.
Horn, C.
Hottenga, J. J.
Hougaard, D. M.
Ising, M.
Jansen, R.
Jones, I.
Lewis, G.
Jones, L. A.
Jorgenson, E.
Knowles, J. A.
Kohane, I. S.
Kraft, J.
Kretzschmar, W. W.
Kutalik, Z.
Li, Y.
Lind, P. A.
MacIntyre, D. J.
Li, Q. S.
MacKinnon, D. F.
Maier, R. M.
Maier, W.
Marchini, J.
Mbarek, H.
McGrath, P.
McGuffin, P.
Medland, S. E.
Mehta, D.
Middeldorp, C. M.
Lucae, S.
Mihailov, E.
Milaneschi, Y.
Milani, L.
Mondimore, F. M.
Montgomery, G. W.
Mostafavi, S.
Mullins, N.
Nauck, M.
Ng, B.
Nivard, M. G.
Madden, P. A. F.
Nyholt, D. R.
O’Reilly, P. F.
Oskarsson, H.
Owen, M. J.
Painter, J. N.
Pedersen, C. B.
Pedersen, M. G.
Peterson, R. E.
Pettersson, E.
Peyrot, W. J.
Magnusson, P. K.
Pistis, G.
Posthuma, D.
Quiroz, J. A.
Qvist, P.
Rice, J. P.
Riley, B. P.
Rivera, M.
Mirza, S. S.
Schoevers, R.
Schulte, E. C.
Martin, N. G.
Shen, L.
Shi, J.
Shyn, S. I.
Sigurdsson, E.
Sinnamon, G. C. B.
Smit, J. H.
Smith, D. J.
Stefansson, H.
Steinberg, S.
Streit, F.
Metspalu, A.
Strohmaier, J.
Tansey, K. E.
Teismann, H.
Teumer, A.
Thompson, W.
Thomson, P. A.
Thorgeirsson, T. E.
Traylor, M.
Treutlein, J.
Trubetskoy, V.
Mors, O.
Uitterlinden, A. G.
Umbricht, D.
Auwera, S. V.
van Hemert, A. M.
Viktorin, A.
Wang, Y.
Webb, B. T.
Weinsheimer, S. M.
Wellmann, J.
Willemsen, G.
Mortensen, P. B.
Witt, S. H.
Wu, Y.
Xi, H. S.
Yang, J.
Zhang, F.
Arolt, V.
Baune, B. T.
Berger, K.
Boomsma, D. I.
Cichon, S.
Müller-Myhsok, B.
Dannlowski, U.
de Geus, E. J. C.
Nordentoft, M.
Nöthen, M. M.
O’Donovan, M. C.
Paciga, S. A.
Penninx, B. W. J. H.
Perlis, R. H.
Porteous, D. J.
Potash, J. B.
Preisig, M.
Rietschel, M.
Schaefer, C.
Schulze, T. G.
Smoller, J. W.
Stefansson, K.
Tiemeier, H.
Uher, R.
Völzke, H.
Weissman, M. M.
Werge, T.
Lewis, C. M.
Levinson, D. F.
Breen, G.
Børglum, A. D.
Sullivan, P. F.
Whalley, H. C.
Visscher, P. M.
Wray, N. R.
Shen, X.
Howard, D. M.
Adams, M. J.
Hill, W. D.
Clarke, T. K.
McIntosh, A. M.
Deary, I. J.
Ripke, S.
Mattheisen, M.
Trzaskowski, M.
Byrne, E. M.
Abdellaoui, A.
Agerbo, E.
Air, T. M.
Andlauer, T. F. M.
Bacanu, S. A.
Bækvad-Hansen, M.
Beekman, A. T. F.
Bigdeli, T. B.
Binder, E. B.
Bryois, J.
Buttenschøn, H. N.
Bybjerg-Grauholm, J.
Cai, N.
Castelao, E.
Christensen, J. H.
Coleman, J. R. I.
Colodro-Conde, L.
Couvy-Duchesne, B.
Craddock, N.
Crawford, G. E.
Davies, G.
Degenhardt, F.
Derks, E. M.
Direk, N.
Dolan, C. V.
Dunn, E. C.
Eley, T. C.
Escott-Price, V.
Kiadeh, F. F. H.
Finucane, H. K.
Foo, J. C.
Forstner, A. J.
Frank, J.
Gaspar, H. A.
Gill, M.
Goes, F. S.
Gordon, S. D.
Grove, J.
Hall, L. S.
Hansen, C. S.
Hansen, T. F. |
Issue Date: | 2020 |
Source: | 11, (1), 2020 |
Journal: | Nature Communications |
Abstract: | | Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N = 10,674) and replication (N = 11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, in both discovery and replication analyses. Mendelian Randomisation analysis supports a potential causal effect of liability to depression on brain white matter microstructure (β: 0.125 to 0.868, pFDR < 0.043). Several behavioural traits are also associated with depression-PRS (β: 0.014 to 0.180, pFDR: 0.049 to 1.28 × 10−14) and we find a significant and positive interaction between depression-PRS and adverse environmental exposures on mental health outcomes. This study reveals replicable associations between depression-PRS and white matter microstructure. Our results indicate that white matter microstructure differences may be a causal consequence of liability to depression.L20048631902020-05-26
2021-04-06
DOI: | 10.1038/s41467-020-16022-0 |
Resources: | https://www.embase.com/search/results?subaction=viewrecord&id=L2004863190&from=exporthttp://dx.doi.org/10.1038/s41467-020-16022-0
| |
Keywords: | human;insomnia;library science;lifestyle and related phenomena;Likert scale;major clinical study;male;maternal smoking;Mendelian randomization analysis;nuclear magnetic resonance imaging;Patient Health Questionnaire 9;pleiotropy;psychiatric genomics consortium;resting state network;risk factor;scoring system;United Kingdom;birth weight;blood pressure measurement;childhood trauma;cognition;controlled study;depression;educational status;female;genetic correlation;genetic risk score;genome-wide association study;hand grip;household income;adultarterial stiffness;article |
Type: | Article |
| Appears in Sites: | Children's Health Queensland Publications
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