Outcome of children relapsing after first allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia: a retrospective I-BFM analysis of 333 children

Abstract

Outcome of 333 children with acute myeloid leukaemia relapsing after a first allogeneic haematopoietic stem cell transplantation was analyzed. Four-year probability of overall survival (4y-pOS) was 14%. 4y-pOS for 122 children receiving a second haematopoietic stem cell transplantation was 31% and 3% for those that did not (P = <0·0001). Achievement of a subsequent remission impacted survival (P = <0·0001). For patients receiving a second transplant survival with or without achieving a subsequent remission was comparable. Graft source (bone marrow vs. peripheral blood stem cells, P = 0·046) and donor choice (matched family vs. matched unrelated donor, P = 0·029) positively impacted survival after relapse. Disease recurrence and non-relapse mortality at four years reached 45% and 22%. (© 2020 British Society for Haematology and John Wiley & Sons Ltd.)Bejanyan, N., Weisdorf, D.J., Logan, B.R., Wang, H.L., Devine, S.M., de Lima, M., Bunjes, D.W. & Zhang, M.J. 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Subset: MEDLINE; Date of Electronic Publication: 2020 Feb 03. Current Imprints: Publication: Oxford : Wiley-Blackwell; Original Imprints: Publication: Oxford : Blackwell Scientific Publications <br />