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https://dora.health.qld.gov.au/qldresearchjspui/handle/1/3441| Title: | Intertumoral Heterogeneity within Medulloblastoma Subgroups | Authors: | Vasiljevic, Alexandre Jung, Shin Moore, Andrew Hallahan, Andrew R. Chan, Jennifer A. Tirapelli, Daniela P. C. Carlotti, Carlos G. Fouladi, Maryam Pimentel, José Faria, Claudia C. Saad, Ali G. Massimi, Luca Liau, Linda M. Wheeler, Helen Nakamura, Hideo Elbabaa, Samer K. Perezpeña-Diazconti, Mario Chico Ponce de León, Fernando Robinson, Shenandoah Zapotocky, Michal Lassaletta, Alvaro Huang, Annie Hawkins, Cynthia E. Tabori, Uri Bouffet, Eric Bartels, Ute Dirks, Peter B. Rutka, James T. Bader, Gary D. Reimand, Jüri Goldenberg, Anna Ramaswamy, Vijay Taylor, Michael D. Cavalli, Florence M. G. Remke, Marc Rampasek, Ladislav Peacock, John Shih, David J. H. Luu, Betty Garzia, Livia Torchia, Jonathon Nor, Carolina Morrissy, A. Sorana Agnihotri, Sameer Thompson, Yuan Yao Kuzan-Fischer, Claudia M. Farooq, Hamza Isaev, Keren Daniels, Craig Cho, Byung-Kyu Kim, Seung-Ki Wang, Kyu-Chang Lee, Ji Yeoun Grajkowska, Wieslawa A. Perek-Polnik, Marta Faure-Conter, Cecile Jouvet, Anne Giannini, Caterina Nageswara Rao, Amulya A. Li, Kay Ka Wai Ng, Ho-Keung Eberhart, Charles G. Pollack, Ian F. Hamilton, Ronald L. Gillespie, G. Yancey Olson, James M. Leary, Sarah Weiss, William A. Lach, Boleslaw Chambless, Lola B. Thompson, Reid C. Cooper, Michael K. Vibhakar, Rajeev Hauser, Peter van Veelen, Marie-Lise C. Kros, Johan M. French, Pim J. Ra, Young Shin Kumabe, Toshihiro López-Aguilar, Enrique Zitterbart, Karel Sterba, Jaroslav Finocchiaro, Gaetano Massimino, Maura Van Meir, Erwin G. Osuka, Satoru Shofuda, Tomoko Klekner, Almos Zollo, Massimo Leonard, Jeffrey R. Rubin, Joshua B. Jabado, Nada Albrecht, Steffen Mora, Jaume Van Meter, Timothy E. |
Issue Date: | 2017 | Source: | 31, (6), 2017, p. 737 | Pages: | 737 | Journal: | Cancer cell | Abstract: | While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials. (Copyright © 2017 Elsevier Inc. All rights reserved.)Neuro Oncol. 2016 Jul;18(7):982-90. (PMID: 27106407); Acta Neuropathol. 2016 Jun;131(6):803-20. (PMID: 27157931); J Clin Oncol. 2011 Apr 10;29(11):1424-30. (PMID: 21098324); Cancer Cell. 2012 Oct 16;22(4):425-37. (PMID: 23079654); Genome Biol. 2012 Jun 15;13(6):R44. (PMID: 22703947); PLoS One. 2010 Nov 15;5(11):e13984. (PMID: 21085593); Pediatr Blood Cancer. 2010 Apr;54(4):635-7. (PMID: 20146217); Cancer Genet. 2011 Nov;204(11):577-88. (PMID: 22200083); Nature. 2016 Jan 21;529(7586):351-7. (PMID: 26760213); Acta Neuropathol. 2016 Jun;131(6):821-31. (PMID: 27040285); Acta Neuropathol. 2011 Aug;122(2):231-40. (PMID: 21681522); Nat Methods. 2014 Sep;11(9):884-885. (PMID: 25166867); Cancer Cell. 2014 Mar 17;25(3):393-405. (PMID: 24651015); Genome Res. 2003 Nov;13(11):2498-504. (PMID: 14597658); Acta Neuropathol. 2013 Dec;126(6):917-29. (PMID: 24174164); Cell. 2014 Aug 14;158(4):929-944. (PMID: 25109877); Acta Neuropathol. 2012 Apr;123(4):465-72. (PMID: 22134537); Cancer Cell. 2016 Mar 14;29(3):311-323. (PMID: 26977882); N Engl J Med. 2015 Jun 25;372(26):2481-98. (PMID: 26061751); Nature. 2012 Aug 2;488(7409):49-56. (PMID: 22832581); Nucleic Acids Res. 2017 Feb 28;45(4):e22. (PMID: 27924034); Acta Neuropathol. 2013 Jun;125(6):913-6. (PMID: 23670100); J Clin Oncol. 2013 Aug 10;31(23):2927-35. (PMID: 23835706); Bioinformatics. 2004 Feb 12;20(3):307-15. (PMID: 14960456); Nucleic Acids Res. 2016 Jul 8;44(W1):W83-9. (PMID: 27098042); Bioinformatics. 2014 May 15;30(10):1363-9. (PMID: 24478339); Nat Rev Cancer. 2012 Dec;12(12):818-34. (PMID: 23175120); Genome Biol. 2011;12(4):R41. (PMID: 21527027); Pediatr Blood Cancer. 2016 Sep;63(9):1527-34. (PMID: 27145464); Bioinformatics. 2009 Nov 15;25(22):2906-12. (PMID: 19759197); Comput Graph Forum. 2012 Jun;31(33):1175-1184. (PMID: 27942089); Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4245-50. (PMID: 23431203); Bioinformatics. 2015 Jun 1;31(11):1839-41. (PMID: 25609794); Bioinformatics. 2009 Feb 1;25(3):415-6. (PMID: 19106121); Nature. 2014 Jul 24;511(7510):428-34. (PMID: 25043047); BMC Bioinformatics. 2010 Jul 02;11:367. (PMID: 20598126); Neuro Oncol. 2016 Feb;18(2):291-7. (PMID: 25605817); Lancet Oncol. 2013 Nov;14(12):1200-7. (PMID: 24140199); Nat Methods. 2014 Mar;11(3):333-7. (PMID: 24464287); Bioinformatics. 2010 Jun 15;26(12):1572-3. (PMID: 20427518); Lancet Oncol. 2016 Apr;17(4):484-495. (PMID: 26976201); Nucleic Acids Res. 2005 Nov 10;33(20):e175. (PMID: 16284200). Linking ISSN: 15356108. Subset: MEDLINE; Grant Information: R01 NS055089 United States NS NINDS NIH HHS; P41 GM103504 United States GM NIGMS NIH HHS; R01 CA159859 United States CA NCI NIH HHS; Canada CIHR; R01 CA148699 United States CA NCI NIH HHS Date of Electronic Publication: 20170612. ; Original Imprints: Publication: Cambridge, Mass. : Cell Press, c2002- | DOI: | 10.1016/j.ccell.2017.05.005 | Resources: | https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,athens&db=mdc&AN=28609654&site=ehost-live | Keywords: | methylation*;subgroups*;Cluster Analysis;Cohort Studies;DNA Copy Number Variations;DNA Methylation;Gene Expression Profiling;Genomics;Humans;Medulloblastoma/genetics;Medulloblastoma/therapy;copy number*;gene expression*;integrative clustering*;medulloblastoma*;Precision Medicine*Medulloblastoma/*classification | Type: | Article |
| Appears in Sites: | Children's Health Queensland Publications |
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