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dc.contributor.authorAgee, M.en
dc.contributor.authorNöthen, M. M.en
dc.contributor.authorO’Donovan, M. C.en
dc.contributor.authorPaciga, S. A.en
dc.contributor.authorPedersen, N. L.en
dc.contributor.authorPenninx, B. W. J. H.en
dc.contributor.authorPerlis, R. H.en
dc.contributor.authorPorteous, D. J.en
dc.contributor.authorPotash, J. B.en
dc.contributor.authorPreisig, M.en
dc.contributor.authorRietschel, M.en
dc.contributor.authorPedersen, M. G.en
dc.contributor.authordPoterba, T.en
dc.contributor.authorPoulsen, J. B.en
dc.contributor.authorPourcain, B. S.en
dc.contributor.authorQvist, P.en
dc.contributor.authorRehnström, K.en
dc.contributor.authorReichenberg, A.en
dc.contributor.authorReichert, J.en
dc.contributor.authorRobinson, E. B.en
dc.contributor.authorRoeder, K.en
dc.contributor.authorSchaefer, C.en
dc.contributor.authorRoussos, P.en
dc.contributor.authorSaemundsen, E.en
dc.contributor.authorSandin, S.en
dc.contributor.authorSatterstrom, F. K.en
dc.contributor.authorDavey Smith, G.en
dc.contributor.authorStefansson, H.en
dc.contributor.authorSteinberg, S.en
dc.contributor.authorStevens, C. R.en
dc.contributor.authorSullivan, P. F.en
dc.contributor.authorTurley, P.en
dc.contributor.authorSchulze, T. G.en
dc.contributor.authorWalters, G. B.en
dc.contributor.authorXu, X.en
dc.contributor.authorTrzaskowski, M.en
dc.contributor.authorByrne, E. M.en
dc.contributor.authorAbdellaoui, A.en
dc.contributor.authorAdams, M. J.en
dc.contributor.authorAir, T. M.en
dc.contributor.authorAndlauer, T. F. M.en
dc.contributor.authorBacanu, S. A.en
dc.contributor.authorBeekman, A. T. F.en
dc.contributor.authorSmoller, J. W.en
dc.contributor.authorBigdeli, T. B.en
dc.contributor.authorBinder, E. B.en
dc.contributor.authorBlackwood, D. H. R.en
dc.contributor.authorBryois, J.en
dc.contributor.authorButtenschøn, H. N.en
dc.contributor.authorCai, N.en
dc.contributor.authorCastelao, E.en
dc.contributor.authorClarke, T. K.en
dc.contributor.authorColeman, J. R. I.en
dc.contributor.authorColodro-Conde, L.en
dc.contributor.authorTiemeier, H.en
dc.contributor.authorCouvy-Duchesne, B.en
dc.contributor.authorCraddock, N.en
dc.contributor.authorCrawford, G. E.en
dc.contributor.authorDavies, G.en
dc.contributor.authorDeary, I. J.en
dc.contributor.authorDegenhardt, F.en
dc.contributor.authorDerks, E. M.en
dc.contributor.authorDirek, N.en
dc.contributor.authorDolan, C. V.en
dc.contributor.authorDunn, E. C.en
dc.contributor.authorUher, R.en
dc.contributor.authorEley, T. C.en
dc.contributor.authorEscott-Price, V.en
dc.contributor.authorKiadeh, F. F. H.en
dc.contributor.authorFinucane, H. K.en
dc.contributor.authorForstner, A. J.en
dc.contributor.authorFrank, J.en
dc.contributor.authorGaspar, H. A.en
dc.contributor.authorGill, M.en
dc.contributor.authorGoes, F. S.en
dc.contributor.authorGordon, S. D.en
dc.contributor.authorVölzke, H.en
dc.contributor.authorHall, L. S.en
dc.contributor.authorHansen, T. F.en
dc.contributor.authorHerms, S.en
dc.contributor.authorHickie, I. B.en
dc.contributor.authorHoffmann, P.en
dc.contributor.authorHomuth, G.en
dc.contributor.authorHorn, C.en
dc.contributor.authorHottenga, J. J.en
dc.contributor.authorIsing, M.en
dc.contributor.authorJansen, R.en
dc.contributor.authorWeissman, M. M.en
dc.contributor.authorJorgenson, E.en
dc.contributor.authorKnowles, J. A.en
dc.contributor.authorKohane, I. S.en
dc.contributor.authorKraft, J.en
dc.contributor.authorKretzschmar, W. W.en
dc.contributor.authorKrogh, J.en
dc.contributor.authorKutalik, Z.en
dc.contributor.authorLi, Y.en
dc.contributor.authorLind, P. A.en
dc.contributor.authorMacIntyre, D. J.en
dc.contributor.authorLewis, C. M.en
dc.contributor.authorMacKinnon, D. F.en
dc.contributor.authorMaier, R. M.en
dc.contributor.authorMaier, W.en
dc.contributor.authorMarchini, J.en
dc.contributor.authorMbarek, H.en
dc.contributor.authorMcGrath, P.en
dc.contributor.authorMcGuffin, P.en
dc.contributor.authorMedland, S. E.en
dc.contributor.authorMehta, D.en
dc.contributor.authorMiddeldorp, C. M.en
dc.contributor.authorLevinson, D. F.en
dc.contributor.authorMihailov, E.en
dc.contributor.authorMilaneschi, Y.en
dc.contributor.authorMilani, L.en
dc.contributor.authorMondimore, F. M.en
dc.contributor.authorMontgomery, G. W.en
dc.contributor.authorMostafavi, S.en
dc.contributor.authorMullins, N.en
dc.contributor.authorNauck, M.en
dc.contributor.authorNg, B.en
dc.contributor.authorNivard, M. G.en
dc.contributor.authorBreen, G.en
dc.contributor.authorNyholt, D. R.en
dc.contributor.authorO’Reilly, P. F.en
dc.contributor.authorOskarsson, H.en
dc.contributor.authorOwen, M. J.en
dc.contributor.authorPainter, J. N.en
dc.contributor.authorPeterson, R. E.en
dc.contributor.authorPettersson, E.en
dc.contributor.authorPeyrot, W. J.en
dc.contributor.authorPistis, G.en
dc.contributor.authorPosthuma, D.en
dc.contributor.authorAlipanahi, B.en
dc.contributor.authorQuiroz, J. A.en
dc.contributor.authorRice, J. P.en
dc.contributor.authorRiley, B. P.en
dc.contributor.authorRivera, M.en
dc.contributor.authorMirza, S. S.en
dc.contributor.authorSchoevers, R.en
dc.contributor.authorSchulte, E. C.en
dc.contributor.authorShen, L.en
dc.contributor.authorShi, J.en
dc.contributor.authorShyn, S. I.en
dc.contributor.authorAuton, A.en
dc.contributor.authorSigurdsson, E.en
dc.contributor.authorSinnamon, G. C. B.en
dc.contributor.authorSmit, J. H.en
dc.contributor.authorSmith, D. J.en
dc.contributor.authorStreit, F.en
dc.contributor.authorStrohmaier, J.en
dc.contributor.authorTansey, K. E.en
dc.contributor.authorTeismann, H.en
dc.contributor.authorTeumer, A.en
dc.contributor.authorThompson, W.en
dc.contributor.authorBell, R. K.en
dc.contributor.authorThomson, P. A.en
dc.contributor.authorThorgeirsson, T. E.en
dc.contributor.authorTraylor, M.en
dc.contributor.authorTreutlein, J.en
dc.contributor.authorTrubetskoy, V.en
dc.contributor.authorUitterlinden, A. G.en
dc.contributor.authorUmbricht, D.en
dc.contributor.authorVan der Auwera, S.en
dc.contributor.authorvan Hemert, A. M.en
dc.contributor.authorViktorin, A.en
dc.contributor.authorBryc, K.en
dc.contributor.authorWang, Y.en
dc.contributor.authorWebb, B. T.en
dc.contributor.authorWeinsheimer, S. M.en
dc.contributor.authorWellmann, J.en
dc.contributor.authorWillemsen, G.en
dc.contributor.authorWitt, S. H.en
dc.contributor.authorWu, Y.en
dc.contributor.authorXi, H. S.en
dc.contributor.authorYang, J.en
dc.contributor.authorZhang, F.en
dc.contributor.authorElson, S. L.en
dc.contributor.authorArolt, V.en
dc.contributor.authorBaune, B. T.en
dc.contributor.authorBerger, K.en
dc.contributor.authorBoomsma, D. I.en
dc.contributor.authorCichon, S.en
dc.contributor.authorDannlowski, U.en
dc.contributor.authorde Geus, E. J. C.en
dc.contributor.authorDePaulo, J. R.en
dc.contributor.authorDomenici, E.en
dc.contributor.authorDomschke, K.en
dc.contributor.authorFontanillas, P.en
dc.contributor.authorEsko, T.en
dc.contributor.authorGrabe, H. J.en
dc.contributor.authorHamilton, S. P.en
dc.contributor.authorHayward, C.en
dc.contributor.authorHeath, A. C.en
dc.contributor.authorKendler, K. S.en
dc.contributor.authorKloiber, S.en
dc.contributor.authorLewis, G.en
dc.contributor.authorLi, Q. S.en
dc.contributor.authorLucae, S.en
dc.contributor.authorFurlotte, N. A.en
dc.contributor.authorMadden, P. A. F.en
dc.contributor.authorMagnusson, P. K.en
dc.contributor.authorMartin, N. G.en
dc.contributor.authorMcIntosh, A. M.en
dc.contributor.authorMetspalu, A.en
dc.contributor.authorMüller-Myhsok, B.en
dc.contributor.authorHromatka, B. S.en
dc.contributor.authorHuber, K. E.en
dc.contributor.authorKleinman, A.en
dc.contributor.authorLitterman, N. K.en
dc.contributor.authorMcIntyre, M. H.en
dc.contributor.authorMountain, J. L.en
dc.contributor.authorNoblin, E. S.en
dc.contributor.authorNorthover, C. A. M.en
dc.contributor.authorPitts, S. J.en
dc.contributor.authorSathirapongsasuti, J. F.en
dc.contributor.authorSazonova, O. V.en
dc.contributor.authorShelton, J. F.en
dc.contributor.authorShringarpure, S.en
dc.contributor.authorTung, J. Y.en
dc.contributor.authorVacic, V.en
dc.contributor.authorWilson, C. H.en
dc.contributor.authorStefansson, K.en
dc.contributor.authorGeschwind, D. H.en
dc.contributor.authorNordentoft, M.en
dc.contributor.authorHougaard, D. M.en
dc.contributor.authorWerge, T.en
dc.contributor.authorMors, O.en
dc.contributor.authorMortensen, P. B.en
dc.contributor.authorNeale, B. M.en
dc.contributor.authorDaly, M. J.en
dc.contributor.authorBørglum, A. D.en
dc.contributor.authorVisscher, P. M.en
dc.contributor.authorWray, N. R.en
dc.contributor.authorGrove, J.en
dc.contributor.authorRipke, S.en
dc.contributor.authorAls, T. D.en
dc.contributor.authorMattheisen, M.en
dc.contributor.authorWalters, R. K.en
dc.contributor.authorWon, H.en
dc.contributor.authorPallesen, J.en
dc.contributor.authorAgerbo, E.en
dc.contributor.authorAndreassen, O. A.en
dc.contributor.authorAnney, R.en
dc.contributor.authorAwashti, S.en
dc.contributor.authorBelliveau, R.en
dc.contributor.authorBettella, F.en
dc.contributor.authorBuxbaum, J. D.en
dc.contributor.authorBybjerg-Grauholm, J.en
dc.contributor.authorBækvad-Hansen, M.en
dc.contributor.authorCerrato, F.en
dc.contributor.authorChambert, K.en
dc.contributor.authorChristensen, J. H.en
dc.contributor.authorChurchhouse, C.en
dc.contributor.authorDellenvall, K.en
dc.contributor.authorDemontis, D.en
dc.contributor.authorDe Rubeis, S.en
dc.contributor.authorDevlin, B.en
dc.contributor.authorDjurovic, S.en
dc.contributor.authorDumont, A. L.en
dc.contributor.authorGoldstein, J. I.en
dc.contributor.authorHansen, C. S.en
dc.contributor.authorHauberg, M. E.en
dc.contributor.authorHollegaard, M. V.en
dc.contributor.authorHope, S.en
dc.contributor.authorHowrigan, D. P.en
dc.contributor.authorHuang, H.en
dc.contributor.authorHultman, C. M.en
dc.contributor.authorKlei, L.en
dc.contributor.authorMaller, J.en
dc.contributor.authorMartin, J.en
dc.contributor.authorMartin, A. R.en
dc.contributor.authorMoran, J. L.en
dc.contributor.authorNyegaard, M.en
dc.contributor.authorNærland, T.en
dc.contributor.authorPalmer, D. S.en
dc.contributor.authorPalotie, A.en
dc.contributor.authorPedersen, C. B.en
dc.date.accessioned2022-11-07T23:40:22Z-
dc.date.available2022-11-07T23:40:22Z-
dc.date.issued2019en
dc.identifier.citation51, (3), 2019, p. 431-444en
dc.identifier.otherRISen
dc.identifier.urihttp://dora.health.qld.gov.au/qldresearchjspui/handle/1/3253-
dc.description.abstractAutism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no individual variants have been robustly associated with ASD. With a marked sample-size increase from a unique Danish population resource, we report a genome-wide association meta-analysis of 18,381 individuals with ASD and 27,969 controls that identified five genome-wide-significant loci. Leveraging GWAS results from three phenotypes with significantly overlapping genetic architectures (schizophrenia, major depression, and educational attainment), we identified seven additional loci shared with other traits at equally strict significance levels. Dissecting the polygenic architecture, we found both quantitative and qualitative polygenic heterogeneity across ASD subtypes. These results highlight biological insights, particularly relating to neuronal function and corticogenesis, and establish that GWAS performed at scale will be much more productive in the near term in ASD.L6265335322019-03-04 <br />2019-10-31 <br />en
dc.language.isoenen
dc.relation.ispartofNature Geneticsen
dc.titleIdentification of common genetic risk variants for autism spectrum disorderen
dc.typeArticleen
dc.identifier.doi10.1038/s41588-019-0344-8en
dc.subject.keywordsmaleen
dc.subject.keywordsmeta analysisen
dc.subject.keywordsNorwayen
dc.subject.keywordsoverlapping geneen
dc.subject.keywordsphenotypeen
dc.subject.keywordsprevalenceen
dc.subject.keywordsprincipal component analysisen
dc.subject.keywordspriority journalen
dc.subject.keywordspromoter regionen
dc.subject.keywordssingle nucleotide polymorphismen
dc.subject.keywordsSwedenen
dc.subject.keywordstranscriptomicsen
dc.subject.keywordsX chromosomeen
dc.subject.keywordsgene locusen
dc.subject.keywordsgenetic correlationen
dc.subject.keywordsgenetic heterogeneityen
dc.subject.keywordsgenetic risken
dc.subject.keywordsgenetic risk scoreen
dc.subject.keywordsgenetic variabilityen
dc.subject.keywordsgenome-wide association studyen
dc.subject.keywordsheritabilityen
dc.subject.keywordshumanen
dc.subject.keywordsICD-10en
dc.subject.keywordsIcelanden
dc.subject.keywordsmajor clinical studyen
dc.subject.keywordsmajor depressionen
dc.subject.keywordsfetus brainen
dc.subject.keywordsFinlanden
dc.subject.keywordsgene identificationen
dc.subject.keywordsarchitecturearticleen
dc.subject.keywordsAsperger syndromeen
dc.subject.keywordsautismen
dc.subject.keywordsbrainen
dc.subject.keywordscase control studyen
dc.subject.keywordscohort analysisen
dc.subject.keywordscontrolled studyen
dc.subject.keywordsDenmarken
dc.subject.keywordseducational statusen
dc.subject.keywordsfemaleen
dc.relation.urlhttps://www.embase.com/search/results?subaction=viewrecord&id=L626533532&from=exporthttp://dx.doi.org/10.1038/s41588-019-0344-8 |en
dc.identifier.risid3025en
dc.description.pages431-444en
local.message.claim2024-06-13T14:21:25.668+1000|||rp04980|||submit_approve|||dc_contributor_author|||None*
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Sites:Children's Health Queensland Publications
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