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https://dora.health.qld.gov.au/qldresearchjspui/handle/1/2817| Title: | Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium | Authors: | Jabbour, Nassib Cullen, Mairi Daniels, Thomas Dempsey, Owen Denton, Miles Desai, Maya Drew, Richard J. Edenborough, Frank Evans, Jason Folb, Jonathan Humphrey, Helen Isalska, Barbara Jensen-Fangel, Søren Jönsson, Bodil Jones, Andrew M. Katzenstein, Terese L. Lillebaek, Troels MacGregor, Gordon Mayell, Sarah Millar, Michael Modha, Deborah Nash, Edward F. O'Brien, Christopher O'Brien, Deirdre Ohri, Chandra Pao, Caroline S. Peckham, Daniel Perrin, Felicity Perry, Audrey Pressler, Tania Prtak, Laura Qvist, Tavs Robb, Ali Schaffer, Kirsten Shafi, Nadia van Ingen, Jakko Walshaw, Martin Watson, Danie West, Noreen Whitehouse, Joanna Haworth, Charles S. Harris, Simon R. Ordway, Diane Parkhill, Julian Floto, R. Andres Coulter, Chris Rodgers, Helen Bryant, Josephine M. Grogono, Dorothy M. Rodriguez-Rincon, Daniela Everall, Isobel Brown, Karen P. Moreno, Pablo Verma, Deepshikha Hill, Emily Drijkoningen, Judith Gilligan, Peter Esther, Charles R. Noone, Peadar G. Giddings, Olivia Bell, Scott C. Thomson, Rachel Wainwright, Claire Pandey, Sushil Wood, Michelle E. Stockwell, Rebecca E. Ramsay, Kay A. Sherrard, Laura J. Kidd, Timothy J. Johnson, Graham R. Knibbs, Luke D. Morawska, Lidia Sly, Peter D. Jones, Andrew Bilton, Diana Laurenson, Ian Ruddy, Michael Bourke, Stephen Bowler, Ian Cjw Chapman, Stephen J. Clayton, Andrew |
Issue Date: | 2016 | Source: | 354, (6313), 2016, p. 751-757 | Pages: | 751-757 | Journal: | Science (New York, N.Y.) | Abstract: | Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. 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Current Imprints: Publication: | DOI: | 10.1126/science.aaf8156 | Resources: | https://search.ebscohost.com/login.aspx?direct=true&AuthType=ip,athens&db=mdc&AN=27846606&site=ehost-live | Keywords: | Animals;Communicable Diseases, Emerging/epidemiology;Communicable Diseases, Emerging/pathology;Communicable Diseases, Emerging/transmission;Cystic Fibrosis/epidemiology;Cystic Fibrosis/pathology;Genome, Bacterial;Genomics;Humans;Incidence;Lung/microbiology;Lung/pathology;Mice;Mice, SCID;Mycobacterium Infections, Nontuberculous/epidemiology;Mycobacterium Infections, Nontuberculous/pathology;Nontuberculous Mycobacteria/*classification;Mycobacterium Infections, Nontuberculous/transmission;Nontuberculous Mycobacteria/genetics;Nontuberculous Mycobacteria/isolation & purification;Phylogeny;Pneumonia, Bacterial/epidemiology;Pneumonia, Bacterial/microbiology;Pneumonia, Bacterial/pathology;Pneumonia, Bacterial/transmission;Polymorphism, Single Nucleotide;Sequence Analysis, DNA;Mycobacterium Infections, Nontuberculous/*microbiology;Cystic Fibrosis/*microbiology;Drug Resistance, Multiple, Bacterial*Communicable Diseases, Emerging/*microbiology | Type: | Article |
| Appears in Sites: | Children's Health Queensland Publications |
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