Early Motor Repertoire of Very Preterm Infants and Relationships with 2-Year Neurodevelopment

Abstract

The Motor Optimality Score, revised (MOS-R) is an extension of the Prechtl General Movements Assessment. This study aims to determine the relationship between MOS-R and 2-year neurodevelopmental outcomes in a cohort of 169 infants born very preterm (<31 weeks' gestational age), and to examine the predictive validity of the MOS-R at 3-4 months' corrected age (CA) above perinatal variables associated with poor outcomes, including Prechtl fidgety movements. Development at 2 years' CA was assessed using Bayley Scales of Infant and Toddler Development, Third edition (Bayley-III) (motor/cognitive impairment: Bayley-III ≤ 85) and Neurological, Sensory, Motor, Developmental Assessment (NSMDA) (neurosensory motor impairment: NSMDA ≥ 12). Cerebral palsy (CP) was classified at 2 years as definite or clinical. The MOS-R was related to 2-year outcomes: Bayley-III motor (B(MOS-R) = 1.24 95% confidence interval (0.78, 1.70)), cognitive (B(MOS-R) = 0.91 (0.48, 1.35)), NSMDA scores (B(MOS-R) = -0.34 (-0.42, -0.25)), definite CP (odds ratio [OR] 0.67 (0.53, 0.86)), clinical CP (OR 0.74 (0.66, 0.83)) for each 1-point increase in MOS-R. MOS-R ≤ 23 predicted motor (sensitivity 78% (60-91%); specificity 63% (54-72%)) and neurosensory motor impairment (sensitivity 86% (64-97%); specificity 59% (51-68%)). The MOS-R is strongly related to CP and motor and cognitive delay at 2 years and is a good predictor of motor and neurosensory motor impairment.2077-0383Kwong, Amanda K-L <br />Orcid: 0000-0003-2875-6697 <br />Boyd, Roslyn N <br />Orcid: 0000-0002-4919-5975 <br />Chatfield, Mark D <br />Ware, Robert S <br />Colditz, Paul B <br />George, Joanne M <br />Orcid: 0000-0003-4893-6564 <br />IRG1413/Cerebral Palsy Alliance Research Foundation/ <br />2014-074/Financial Markets Foundation for Children/ <br />1084032/National Health and Medical Research Council/ <br />1105038/National Health and Medical Research Council/ <br />WIS162020/Mary McConnel Career Boost Program for Women in Paediatric Research/ <br />Journal Article <br />J Clin Med. 2022 Mar 25;11(7):1833. doi: 10.3390/jcm11071833. <br />