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Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/2647
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dc.contributor.authorMichealraj, K. A.en
dc.contributor.authorFleischhack, G.en
dc.contributor.authorTippelt, S.en
dc.contributor.authorRa, Y. S.en
dc.contributor.authorBailey, S.en
dc.contributor.authorLindsey, J. C.en
dc.contributor.authorClifford, S. C.en
dc.contributor.authorEberhart, C. G.en
dc.contributor.authorCooper, M. K.en
dc.contributor.authorPacker, R. J.en
dc.contributor.authorMassimino, M.en
dc.contributor.authorGarre, M. L.en
dc.contributor.authorBartels, U.en
dc.contributor.authorTabori, U.en
dc.contributor.authorHawkins, C. E.en
dc.contributor.authorDirks, P.en
dc.contributor.authorBouffet, E.en
dc.contributor.authorRutka, J. T.en
dc.contributor.authorWechsler-Reya, R. J.en
dc.contributor.authorWeiss, W. A.en
dc.contributor.authorCollier, L. S.en
dc.contributor.authorDupuy, A. J.en
dc.contributor.authorKorshunov, A.en
dc.contributor.authorJones, D. T. W.en
dc.contributor.authorKool, M.en
dc.contributor.authorNorthcott, P. A.en
dc.contributor.authorPfister, S. M.en
dc.contributor.authorLargaespada, D. A.en
dc.contributor.authorMungall, A. J.en
dc.contributor.authorMoore, R. A.en
dc.contributor.authorJabado, N.en
dc.contributor.authorBader, G. D.en
dc.contributor.authorJones, S. J. M.en
dc.contributor.authorMalkin, D.en
dc.contributor.authorMarra, M. A.en
dc.contributor.authorTaylor, M. D.en
dc.contributor.authorShah, S.en
dc.contributor.authorFarooq, H.en
dc.contributor.authorKijima, N.en
dc.contributor.authorHolgado, B. L.en
dc.contributor.authorMorrissy, A. S.en
dc.contributor.authorGarzia, L.en
dc.contributor.authorShih, D. J. H.en
dc.contributor.authorZuyderduyn, S.en
dc.contributor.authorHuang, X.en
dc.contributor.authorSkowron, P.en
dc.contributor.authorRemke, M.en
dc.contributor.authorCavalli, F. M. G.en
dc.contributor.authorRamaswamy, V.en
dc.contributor.authorLindsay, P. E.en
dc.contributor.authorJelveh, S.en
dc.contributor.authorDonovan, L. K.en
dc.contributor.authorWang, X.en
dc.contributor.authorLuu, B.en
dc.contributor.authorZayne, K.en
dc.contributor.authorLi, Y.en
dc.contributor.authorMayoh, C.en
dc.contributor.authorThiessen, N.en
dc.contributor.authorMercier, E.en
dc.contributor.authorMungall, K. L.en
dc.contributor.authorMa, Y.en
dc.contributor.authorTse, K.en
dc.contributor.authorZeng, T.en
dc.contributor.authorShumansky, K.en
dc.contributor.authorRoth, A. J. L.en
dc.contributor.authorLee, J. J. Y.en
dc.contributor.authorMatan-Lithwick, S.en
dc.contributor.authorLiu, J.en
dc.contributor.authorMack, S. C.en
dc.contributor.authorManno, A.en
dc.contributor.authorNor, C.en
dc.contributor.authorPeacock, J.en
dc.contributor.authorQin, L.en
dc.contributor.authorReimand, J.en
dc.contributor.authorRolider, A.en
dc.contributor.authorThompson, Y. Y.en
dc.contributor.authorWu, X.en
dc.contributor.authorPugh, T.en
dc.contributor.authorAlly, A.en
dc.contributor.authorBilenky, M.en
dc.contributor.authorButterfield, Y. S. N.en
dc.contributor.authorCarlsen, R.en
dc.contributor.authorCheng, Y.en
dc.contributor.authorChuah, E.en
dc.contributor.authorCorbett, R. D.en
dc.contributor.authorDhalla, N.en
dc.contributor.authorHe, A.en
dc.contributor.authorLee, D.en
dc.contributor.authorLi, H. I.en
dc.contributor.authorLong, W.en
dc.contributor.authorMayo, M.en
dc.contributor.authorPlettner, P.en
dc.contributor.authorQian, J. Q.en
dc.contributor.authorSchein, J. E.en
dc.contributor.authorTam, A.en
dc.contributor.authorWong, T.en
dc.contributor.authorBirol, I.en
dc.contributor.authorZhao, Y.en
dc.contributor.authorFaria, C. C.en
dc.contributor.authorPimentel, J.en
dc.contributor.authorNunes, S.en
dc.contributor.authorShalaby, T.en
dc.contributor.authorGrotzer, M.en
dc.contributor.authorPollack, I. F.en
dc.contributor.authorHamilton, R. L.en
dc.contributor.authorLi, X. N.en
dc.contributor.authorBendel, A. E.en
dc.contributor.authorFults, D. W.en
dc.contributor.authorWalter, A. W.en
dc.contributor.authorKumabe, T.en
dc.contributor.authorTominaga, T.en
dc.contributor.authorCollins, V. P.en
dc.contributor.authorCho, Y. J.en
dc.contributor.authorHoffman, C.en
dc.contributor.authorLyden, D.en
dc.contributor.authorWisoff, J. H.en
dc.contributor.authorGarvin, J. H.en
dc.contributor.authorStearns, D. S.en
dc.contributor.authorMassimi, L.en
dc.contributor.authorSchüller, U.en
dc.contributor.authorSterba, J.en
dc.contributor.authorZitterbart, K.en
dc.contributor.authorPuget, S.en
dc.contributor.authorAyrault, O.en
dc.contributor.authorDunn, S. E.en
dc.contributor.authorTirapelli, D. P. C.en
dc.contributor.authorCarlotti, C. G.en
dc.contributor.authorWheeler, H.en
dc.contributor.authorHallahan, A. R.en
dc.contributor.authorIngram, W.en
dc.contributor.authorMacDonald, T. J.en
dc.contributor.authorOlson, J. J.en
dc.contributor.authorVan Meir, E. G.en
dc.contributor.authorLee, J. Y.en
dc.contributor.authorWang, K. C.en
dc.contributor.authorKim, S. K.en
dc.contributor.authorCho, B. K.en
dc.contributor.authorPietsch, T.en
dc.date.accessioned2022-11-07T23:33:48Z-
dc.date.available2022-11-07T23:33:48Z-
dc.date.issued2016en
dc.identifier.citation529, (7586), 2016, p. 351-357en
dc.identifier.otherRISen
dc.identifier.urihttp://dora.health.qld.gov.au/qldresearchjspui/handle/1/2647-
dc.description.abstractThe development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma with 'humanized' in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (<5%). Whole-genome sequencing of 33 pairs of human diagnostic and post-therapy medulloblastomas demonstrated substantial genetic divergence of the dominant clone after therapy (<12% diagnostic events were retained at recurrence). In both mice and humans, the dominant clone at recurrence arose through clonal selection of a pre-existing minor clone present at diagnosis. Targeted therapy is unlikely to be effective in the absence of the target, therefore our results offer a simple, proximal, and remediable explanation for the failure of prior clinical trials of targeted therapy.L6078216062016-02-02 <br />2016-02-09 <br />en
dc.language.isoenen
dc.relation.ispartofNatureen
dc.titleDivergent clonal selection dominates medulloblastoma at recurrenceen
dc.typeArticleen
dc.identifier.doi10.1038/nature16478en
dc.subject.keywordsin vivo studyen
dc.subject.keywordsmedulloblastomaen
dc.subject.keywordsmouseen
dc.subject.keywordsnonhumanen
dc.subject.keywordspriority journalen
dc.subject.keywordssignal transductionen
dc.subject.keywordsextracellular matrixen
dc.subject.keywordscell surface receptorprotein p53en
dc.subject.keywordssonic hedgehog proteinen
dc.subject.keywordsanimal modelen
dc.subject.keywordsarticleen
dc.subject.keywordscancer recurrenceen
dc.subject.keywordscancer resistanceen
dc.subject.keywordsclinical trial (topic)en
dc.subject.keywordscloneen
dc.subject.keywordsgene mutationen
dc.subject.keywordsgene sequenceen
dc.subject.keywordsgenetic variabilityen
dc.subject.keywordsgenomeen
dc.relation.urlhttps://www.embase.com/search/results?subaction=viewrecord&id=L607821606&from=exporthttp://dx.doi.org/10.1038/nature16478 |en
dc.identifier.risid2977en
dc.description.pages351-357en
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.openairetypeArticle-
item.grantfulltextnone-
item.fulltextNo Fulltext-
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