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https://dora.health.qld.gov.au/qldresearchjspui/handle/1/2181| Title: | Cardiopulmonary bypass in a child with severe Factor XII deficiency | Authors: | Shrimpton, N. Barbaro, P. Rane, M. Patukale, A. Venugopal, P. Alphonso, N. |
Issue Date: | 2022 | Source: | 37, (3), 2022, p. 316-320 | Pages: | 316-320 | Journal: | Perfusion (United Kingdom) | Abstract: | Factor XII (FXII) deficiency presents as a prolonged activated partial thromboplastin time (aPTT) but is not associated with clinically significant bleeding. Activated clotting time (ACT) is used routinely to monitor anticoagulation with unfractionated heparin in patients undergoing cardiopulmonary bypass (CPB). The coagulation activator reagents in most ACT tests are dependent on adequate FXII concentrations to initiate contact factor coagulation pathways. We report the case of a 14.7 kg girl undergoing CPB with a pre-admission FXII concentration of <1% and aPTT >200 seconds. The child was transfused with fresh-frozen plasma to replenish FXII, allowing safe ACT monitoring of heparin anticoagulation throughout CPB.L20107046072021-03-12 | DOI: | 10.1177/0267659121999305 | Resources: | https://www.embase.com/search/results?subaction=viewrecord&id=L2010704607&from=exporthttp://dx.doi.org/10.1177/0267659121999305 | | Keywords: | blood clotting;blood clotting factor 12 deficiency;blood clotting time;cardiopulmonary bypass;case report;child;clinical article;disease severity;extracorporeal circulation;SMARxT coated tubing;hospital admission;human;preschool child;thromboelastography;venous return;Capiox FX05 Baby-FX hollow fibre oxygenatormembrane oxygenator;female;antifibrinolytic agent;heparin;article | Type: | Article |
| Appears in Sites: | Children's Health Queensland Publications |
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