Analysis of shared heritability in common disorders of the brain

Wray, N. R.; Kendler, K. S.; Koeleman, B.; Mathews, C. A.; Price, A.; Scharf, J.; Sklar, P.; Williams, J.; Wood, N. W.; Cotsapas, C.; Palotie, A.; Bis, J. C.; Ruiz, A.; Boada, M.; Seshadri, S.; Beiser, A.; Rice, K.; van der Lee, S. J.; De Jager, P. L.; Geschwind, D. H.; Riemenschneider, M.; Smoller, J. W.; Riedel-Heller, S.; Rotter, J. I.; Ransmayr, G.; Hyman, B. T.; Cruchaga, C.; Alegret, M.; Winsvold, B.; Palta, P.; Farh, K. H.; Cuenca-Leon, E.; Sullivan, P.; Furlotte, N.; Kurth, T.; Ligthart, L.; Terwindt, G. M.; Freilinger, T.; Ran, C.; Gordon, S. D.; Borck, G.; Adams, H. H. H.; Lehtimäki, T.; Rosand, J.; Wedenoja, J.; Buring, J. E.; Schürks, M.; Hrafnsdottir, M.; Hottenga, J. J.; Penninx, B.; Artto, V.; Kaunisto, M.; Vepsäläinen, S.; Martin, N. G.; Corvin, A.; Montgomery, G. W.; Kurki, M. I.; Hämäläinen, E.; Huang, H.; Huang, J.; Sandor, C.; Webber, C.; Muller-Myhsok, B.; Schreiber, S.; Salomaa, V.; Neale, B. M.; Loehrer, E.; Göbel, H.; Macaya, A.; Pozo-Rosich, P.; Hansen, T.; Werge, T.; Kaprio, J.; Metspalu, A.; Kubisch, C.; Ferrari, M. D.; Schott, J. M.; Belin, A. C.; van den Maagdenberg, Amjm; Zwart, J. A.; Boomsma, D.; Eriksson, N.; Olesen, J.; Chasman, D. I.; Nyholt, D. R.; Avbersek, A.; Baum, L.; Anney, R.; Berkovic, S.; Bradfield, J.; Buono, R. J.; Catarino, C. B.; Cossette, P.; De Jonghe, P.; Depondt, C.; Dlugos, D.; Ferraro, T. N.; French, J.; Elia, J.; Hjalgrim, H.; Jamnadas-Khoda, J.; Kälviäinen, R.; Kunz, W. S.; Lerche, H.; Leu, C.; Lindhout, D.; Lo, W.; Lowenstein, D.; McCormack, M.; Grigoroiu-Serbanescu, M.; Møller, R. S.; Molloy, A.; Ng, P. W.; Oliver, K.; Privitera, M.; Radtke, R.; Ruppert, A. K.; Sander, T.; Schachter, S.; Schankin, C.; Edenberg, H. J.; Scheffer, I.; Schoch, S.; Sisodiya, S. M.; Smith, P.; Sperling, M.; Striano, P.; Surges, R.; Thomas, G. N.; Visscher, F.; Whelan, C. D.; Murray, R.; Zara, F.; Heinzen, E. L.; Marson, A.; Becker, F.; Stroink, H.; Zimprich, F.; Gasser, T.; Gibbs, R.; Heutink, P.; Martinez, M.; Anttila, V.; Morris, H. R.; Sharma, M.; Ryten, M.; Mok, K. Y.; Pulit, S.; Bevan, S.; Holliday, E.; Attia, J.; Battey, T.; Boncoraglio, G.; Bulik-Sullivan, B.; Thijs, V.; Chen, W. M.; Mitchell, B.; Rothwell, P.; Sharma, P.; Sudlow, C.; Vicente, A.; Markus, H.; Kourkoulis, C.; Pera, J.; Finucane, H. K.; Raffeld, M.; Silliman, S.; Boraska Perica, V.; Thornton, L. M.; Huckins, L. M.; William Rayner, N.; Lewis, C. M.; Gratacos, M.; Rybakowski, F.; Keski-Rahkonen, A.; Walters, R. K.; Raevuori, A.; Hudson, J. I.; Reichborn-Kjennerud, T.; Monteleone, P.; Karwautz, A.; Mannik, K.; Baker, J. H.; O'Toole, J. K.; Trace, S. E.; Davis, O. S. P.; Bras, J.; Helder, S. G.; Ehrlich, S.; Herpertz-Dahlmann, B.; Danner, U. N.; van Elburg, A. A.; Clementi, M.; Forzan, M.; Docampo, E.; Lissowska, J.; Hauser, J.; Duncan, L.; Tortorella, A.; Maj, M.; Gonidakis, F.; Tziouvas, K.; Papezova, H.; Yilmaz, Z.; Wagner, G.; Cohen-Woods, S.; Herms, S.; Julià, A.; Escott-Price, V.; Rabionet, R.; Dick, D. M.; Ripatti, S.; Andreassen, O. A.; Espeseth, T.; Lundervold, A. J.; Steen, V. M.; Pinto, D.; Scherer, S. W.; Aschauer, H.; Falcone, G. J.; Schosser, A.; Alfredsson, L.; Padyukov, L.; Halmi, K. A.; Mitchell, J.; Strober, M.; Bergen, A. W.; Kaye, W.; Szatkiewicz, J. P.; Cormand, B.; Gormley, P.; Ramos-Quiroga, J. A.; Sánchez-Mora, C.; Ribasés, M.; Casas, M.; Hervas, A.; Arranz, M. J.; Haavik, J.; Zayats, T.; Johansson, S.; Williams, N.; Malik, R.; Dempfle, A.; Rothenberger, A.; Kuntsi, J.; Oades, R. D.; Banaschewski, T.; Franke, B.; Buitelaar, J. K.; Arias Vasquez, A.; Doyle, A. E.; Reif, A.; Patsopoulos, N. A.; Lesch, K. P.; Freitag, C.; Rivero, O.; Palmason, H.; Romanos, M.; Langley, K.; Rietschel, M.; Witt, S. H.; Dalsgaard, S.; Børglum, A. D.; Ripke, S.; Waldman, I.; Wilmot, B.; Molly, N.; Bau, C. H. D.; Crosbie, J.; Schachar, R.; Loo, S. K.; McGough, J. J.; Grevet, E. H.; Medland, S. E.; Wei, Z.; Robinson, E.; Weiss, L. A.; Bacchelli, E.; Bailey, A.; Bal, V.; Battaglia, A.; Betancur, C.; Bolton, P.; Cantor, R.; Celestino-Soper, P.; Yu, D.; Dawson, G.; De Rubeis, S.; Duque, F.; Green, A.; Klauck, S. M.; Leboyer, M.; Levitt, P.; Maestrini, E.; Mane, S.; De-Luca, D. M.; Lee, P. H.; Parr, J.; Regan, R.; Reichenberg, A.; Sandin, S.; Vorstman, J.; Wassink, T.; Wijsman, E.; Cook, E.; Santangelo, S.; Delorme, R.; Turley, P.; Rogé, B.; Magalhaes, T.; Arking, D.; Schulze, T. G.; Thompson, R. C.; Strohmaier, J.; Matthews, K.; Melle, I.; Morris, D.; Blackwood, D.; Grenier-Boley, B.; McIntosh, A.; Bergen, S. E.; Schalling, M.; Jamain, S.; Maaser, A.; Fischer, S. B.; Reinbold, C. S.; Fullerton, J. M.; Guzman-Parra, J.; Mayoral, F.; Chouraki, V.; Schofield, P. R.; Cichon, S.; Mühleisen, T. W.; Degenhardt, F.; Schumacher, J.; Bauer, M.; Mitchell, P. B.; Gershon, E. S.; Rice, J.; Potash, J. B.; Kamatani, Y.; Zandi, P. P.; Craddock, N.; Ferrier, I. N.; Alda, M.; Rouleau, G. A.; Turecki, G.; Ophoff, R.; Pato, C.; Anjorin, A.; Stahl, E.; Berr, C.; Leber, M.; Czerski, P. M.; Cruceanu, C.; Jones, I. R.; Posthuma, D.; Andlauer, T. F. M.; Forstner, A. J.; Streit, F.; Baune, B. T.; Air, T.; Letenneur, L.; Sinnamon, G.; MacIntyre, D. J.; Porteous, D.; Homuth, G.; Rivera, M.; Grove, J.; Middeldorp, C. M.; Hickie, I.; Pergadia, M.; Mehta, D.; Hannequin, D.; Smit, J. H.; Jansen, R.; de Geus, E.; Dunn, E.; Li, Q. S.; Nauck, M.; Schoevers, R. A.; Beekman, A. T.; Knowles, J. A.; Viktorin, A.; Amouyel, P.; Arnold, P.; Barr, C. L.; Bedoya-Berrio, G.; Bienvenu, O. J.; Brentani, H.; Burton, C.; Camarena, B.; Cappi, C.; Cath, D.; Cavallini, M.; Boland, A.; Cusi, D.; Darrow, S.; Denys, D.; Derks, E. M.; Dietrich, A.; Fernandez, T.; Figee, M.; Freimer, N.; Gerber, G.; Grados, M.; Deleuze, J. F.; Greenberg, E.; Hanna, G. L.; Hartmann, A.; Hirschtritt, M. E.; Hoekstra, P. J.; Huang, A.; Huyser, C.; Illmann, C.; Jenike, M.; Kuperman, S.; Duron, E.; Leventhal, B.; Lochner, C.; Lyon, G. J.; Macciardi, F.; Madruga-Garrido, M.; Malaty, I. A.; Maras, A.; McGrath, L.; Miguel, E. C.; Mir, P.; Vardarajan, B. N.; Nestadt, G.; Nicolini, H.; Okun, M. S.; Pakstis, A.; Paschou, P.; Piacentini, J.; Pittenger, C.; Plessen, K.; Ramensky, V.; Ramos, E. M.; Reitz, C.; Reus, V.; Richter, M. A.; Riddle, M. A.; Robertson, M. M.; Roessner, V.; Rosário, M.; Samuels, J. F.; Sandor, P.; Stein, D. J.; Tsetsos, F.; Goate, A. M.; Van Nieuwerburgh, F.; Weatherall, S.; Wendland, J. R.; Wolanczyk, T.; Worbe, Y.; Zai, G.; Goes, F. S.; McLaughlin, N.; Nestadt, P. S.; Grabe, H. J.; Huentelman, M. J.; Depienne, C.; Konkashbaev, A.; Lanzagorta, N.; Valencia-Duarte, A.; Bramon, E.; Buccola, N.; Cahn, W.; Cairns, M.; Chong, S. A.; Cohen, D.; Kamboh, M. I.; Crespo-Facorro, B.; Crowley, J.; Davidson, M.; DeLisi, L.; Dinan, T.; Donohoe, G.; Drapeau, E.; Duan, J.; Haan, L.; Hougaard, D.; Larson, E. B.; Karachanak-Yankova, S.; Khrunin, A.; Klovins, J.; Kučinskas, V.; Lee Chee Keong, J.; Limborska, S.; Loughland, C.; Lönnqvist, J.; Maher, B.; Mattheisen, M.; Rogaeva, E.; McDonald, C.; Murphy, K. C.; Nenadic, I.; van Os, J.; Pantelis, C.; Pato, M.; Petryshen, T.; Quested, D.; Roussos, P.; Sanders, A. R.; St George-Hyslop, P.; Schall, U.; Schwab, S. G.; Sim, K.; So, H. C.; Stögmann, E.; Subramaniam, M.; Toncheva, D.; Waddington, J.; Walters, J.; Weiser, M.; Hakonarson, H.; Cheng, W.; Cloninger, R.; Curtis, D.; Gejman, P. V.; Henskens, F.; Mattingsdal, M.; Oh, S. Y.; Scott, R.; Webb, B.; Breen, G.; Kukull, W. A.; Churchhouse, C.; Bulik, C. M.; Daly, M.; Dichgans, M.; Faraone, S. V.; Guerreiro, R.; Holmans, P.; Farrer, L. A.; Barnes, L. L.; Beach, T. G.; Demirci, F. Y.; Head, E.; Hulette, C. M.; Jicha, G. A.; Kauwe, J. S. K.; Kaye, J. A.; Leverenz, J. B.; Levey, A. I.; Lieberman, A. P.; Pankratz, V. S.; Poon, W. W.; Quinn, J. F.; Saykin, A. J.; Schneider, L. S.; Smith, A. G.; Sonnen, J. A.; Stern, R. A.; Van Deerlin, V. M.; Van Eldik, L. J.; Harold, D.; Russo, G.; Rubinsztein, D. C.; Bayer, A.; Tsolaki, M.; Proitsi, P.; Fox, N. C.; Hampel, H.; Owen, M. J.; Mead, S.; Passmore, P.; Morgan, K.; Nöthen, M. M.; Rossor, M.; Lupton, M. K.; Hoffmann, P.; Kornhuber, J.; Lawlor, B.; McQuillin, A.; Al-Chalabi, A.

Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/1908

Title:	Analysis of shared heritability in common disorders of the brain
Authors:	Wray, N. R. Kendler, K. S. Koeleman, B. Mathews, C. A. Price, A. Scharf, J. Sklar, P. Williams, J. Wood, N. W. Cotsapas, C. Palotie, A. Bis, J. C. Ruiz, A. Boada, M. Seshadri, S. Beiser, A. Rice, K. van der Lee, S. J. De Jager, P. L. Geschwind, D. H. Riemenschneider, M. Smoller, J. W. Riedel-Heller, S. Rotter, J. I. Ransmayr, G. Hyman, B. T. Cruchaga, C. Alegret, M. Winsvold, B. Palta, P. Farh, K. H. Cuenca-Leon, E. Sullivan, P. Furlotte, N. Kurth, T. Ligthart, L. Terwindt, G. M. Freilinger, T. Ran, C. Gordon, S. D. Borck, G. Adams, H. H. H. Lehtimäki, T. Rosand, J. Wedenoja, J. Buring, J. E. Schürks, M. Hrafnsdottir, M. Hottenga, J. J. Penninx, B. Artto, V. Kaunisto, M. Vepsäläinen, S. Martin, N. G. Corvin, A. Montgomery, G. W. Kurki, M. I. Hämäläinen, E. Huang, H. Huang, J. Sandor, C. Webber, C. Muller-Myhsok, B. Schreiber, S. Salomaa, V. Neale, B. M. Loehrer, E. Göbel, H. Macaya, A. Pozo-Rosich, P. Hansen, T. Werge, T. Kaprio, J. Metspalu, A. Kubisch, C. Ferrari, M. D. Schott, J. M. Belin, A. C. van den Maagdenberg, Amjm Zwart, J. A. Boomsma, D. Eriksson, N. Olesen, J. Chasman, D. I. Nyholt, D. R. Avbersek, A. Baum, L. Anney, R. Berkovic, S. Bradfield, J. Buono, R. J. Catarino, C. B. Cossette, P. De Jonghe, P. Depondt, C. Dlugos, D. Ferraro, T. N. French, J. Elia, J. Hjalgrim, H. Jamnadas-Khoda, J. Kälviäinen, R. Kunz, W. S. Lerche, H. Leu, C. Lindhout, D. Lo, W. Lowenstein, D. McCormack, M. Grigoroiu-Serbanescu, M. Møller, R. S. Molloy, A. Ng, P. W. Oliver, K. Privitera, M. Radtke, R. Ruppert, A. K. Sander, T. Schachter, S. Schankin, C. Edenberg, H. J. Scheffer, I. Schoch, S. Sisodiya, S. M. Smith, P. Sperling, M. Striano, P. Surges, R. Thomas, G. N. Visscher, F. Whelan, C. D. Murray, R. Zara, F. Heinzen, E. L. Marson, A. Becker, F. Stroink, H. Zimprich, F. Gasser, T. Gibbs, R. Heutink, P. Martinez, M. Anttila, V. Morris, H. R. Sharma, M. Ryten, M. Mok, K. Y. Pulit, S. Bevan, S. Holliday, E. Attia, J. Battey, T. Boncoraglio, G. Bulik-Sullivan, B. Thijs, V. Chen, W. M. Mitchell, B. Rothwell, P. Sharma, P. Sudlow, C. Vicente, A. Markus, H. Kourkoulis, C. Pera, J. Finucane, H. K. Raffeld, M. Silliman, S. Boraska Perica, V. Thornton, L. M. Huckins, L. M. William Rayner, N. Lewis, C. M. Gratacos, M. Rybakowski, F. Keski-Rahkonen, A. Walters, R. K. Raevuori, A. Hudson, J. I. Reichborn-Kjennerud, T. Monteleone, P. Karwautz, A. Mannik, K. Baker, J. H. O'Toole, J. K. Trace, S. E. Davis, O. S. P. Bras, J. Helder, S. G. Ehrlich, S. Herpertz-Dahlmann, B. Danner, U. N. van Elburg, A. A. Clementi, M. Forzan, M. Docampo, E. Lissowska, J. Hauser, J. Duncan, L. Tortorella, A. Maj, M. Gonidakis, F. Tziouvas, K. Papezova, H. Yilmaz, Z. Wagner, G. Cohen-Woods, S. Herms, S. Julià, A. Escott-Price, V. Rabionet, R. Dick, D. M. Ripatti, S. Andreassen, O. A. Espeseth, T. Lundervold, A. J. Steen, V. M. Pinto, D. Scherer, S. W. Aschauer, H. Falcone, G. J. Schosser, A. Alfredsson, L. Padyukov, L. Halmi, K. A. Mitchell, J. Strober, M. Bergen, A. W. Kaye, W. Szatkiewicz, J. P. Cormand, B. Gormley, P. Ramos-Quiroga, J. A. Sánchez-Mora, C. Ribasés, M. Casas, M. Hervas, A. Arranz, M. J. Haavik, J. Zayats, T. Johansson, S. Williams, N. Malik, R. Dempfle, A. Rothenberger, A. Kuntsi, J. Oades, R. D. Banaschewski, T. Franke, B. Buitelaar, J. K. Arias Vasquez, A. Doyle, A. E. Reif, A. Patsopoulos, N. A. Lesch, K. P. Freitag, C. Rivero, O. Palmason, H. Romanos, M. Langley, K. Rietschel, M. Witt, S. H. Dalsgaard, S. Børglum, A. D. Ripke, S. Waldman, I. Wilmot, B. Molly, N. Bau, C. H. D. Crosbie, J. Schachar, R. Loo, S. K. McGough, J. J. Grevet, E. H. Medland, S. E. Wei, Z. Robinson, E. Weiss, L. A. Bacchelli, E. Bailey, A. Bal, V. Battaglia, A. Betancur, C. Bolton, P. Cantor, R. Celestino-Soper, P. Yu, D. Dawson, G. De Rubeis, S. Duque, F. Green, A. Klauck, S. M. Leboyer, M. Levitt, P. Maestrini, E. Mane, S. De-Luca, D. M. Lee, P. H. Parr, J. Regan, R. Reichenberg, A. Sandin, S. Vorstman, J. Wassink, T. Wijsman, E. Cook, E. Santangelo, S. Delorme, R. Turley, P. Rogé, B. Magalhaes, T. Arking, D. Schulze, T. G. Thompson, R. C. Strohmaier, J. Matthews, K. Melle, I. Morris, D. Blackwood, D. Grenier-Boley, B. McIntosh, A. Bergen, S. E. Schalling, M. Jamain, S. Maaser, A. Fischer, S. B. Reinbold, C. S. Fullerton, J. M. Guzman-Parra, J. Mayoral, F. Chouraki, V. Schofield, P. R. Cichon, S. Mühleisen, T. W. Degenhardt, F. Schumacher, J. Bauer, M. Mitchell, P. B. Gershon, E. S. Rice, J. Potash, J. B. Kamatani, Y. Zandi, P. P. Craddock, N. Ferrier, I. N. Alda, M. Rouleau, G. A. Turecki, G. Ophoff, R. Pato, C. Anjorin, A. Stahl, E. Berr, C. Leber, M. Czerski, P. M. Cruceanu, C. Jones, I. R. Posthuma, D. Andlauer, T. F. M. Forstner, A. J. Streit, F. Baune, B. T. Air, T. Letenneur, L. Sinnamon, G. MacIntyre, D. J. Porteous, D. Homuth, G. Rivera, M. Grove, J. Middeldorp, C. M. Hickie, I. Pergadia, M. Mehta, D. Hannequin, D. Smit, J. H. Jansen, R. de Geus, E. Dunn, E. Li, Q. S. Nauck, M. Schoevers, R. A. Beekman, A. T. Knowles, J. A. Viktorin, A. Amouyel, P. Arnold, P. Barr, C. L. Bedoya-Berrio, G. Bienvenu, O. J. Brentani, H. Burton, C. Camarena, B. Cappi, C. Cath, D. Cavallini, M. Boland, A. Cusi, D. Darrow, S. Denys, D. Derks, E. M. Dietrich, A. Fernandez, T. Figee, M. Freimer, N. Gerber, G. Grados, M. Deleuze, J. F. Greenberg, E. Hanna, G. L. Hartmann, A. Hirschtritt, M. E. Hoekstra, P. J. Huang, A. Huyser, C. Illmann, C. Jenike, M. Kuperman, S. Duron, E. Leventhal, B. Lochner, C. Lyon, G. J. Macciardi, F. Madruga-Garrido, M. Malaty, I. A. Maras, A. McGrath, L. Miguel, E. C. Mir, P. Vardarajan, B. N. Nestadt, G. Nicolini, H. Okun, M. S. Pakstis, A. Paschou, P. Piacentini, J. Pittenger, C. Plessen, K. Ramensky, V. Ramos, E. M. Reitz, C. Reus, V. Richter, M. A. Riddle, M. A. Robertson, M. M. Roessner, V. Rosário, M. Samuels, J. F. Sandor, P. Stein, D. J. Tsetsos, F. Goate, A. M. Van Nieuwerburgh, F. Weatherall, S. Wendland, J. R. Wolanczyk, T. Worbe, Y. Zai, G. Goes, F. S. McLaughlin, N. Nestadt, P. S. Grabe, H. J. Huentelman, M. J. Depienne, C. Konkashbaev, A. Lanzagorta, N. Valencia-Duarte, A. Bramon, E. Buccola, N. Cahn, W. Cairns, M. Chong, S. A. Cohen, D. Kamboh, M. I. Crespo-Facorro, B. Crowley, J. Davidson, M. DeLisi, L. Dinan, T. Donohoe, G. Drapeau, E. Duan, J. Haan, L. Hougaard, D. Larson, E. B. Karachanak-Yankova, S. Khrunin, A. Klovins, J. Kučinskas, V. Lee Chee Keong, J. Limborska, S. Loughland, C. Lönnqvist, J. Maher, B. Mattheisen, M. Rogaeva, E. McDonald, C. Murphy, K. C. Nenadic, I. van Os, J. Pantelis, C. Pato, M. Petryshen, T. Quested, D. Roussos, P. Sanders, A. R. St George-Hyslop, P. Schall, U. Schwab, S. G. Sim, K. So, H. C. Stögmann, E. Subramaniam, M. Toncheva, D. Waddington, J. Walters, J. Weiser, M. Hakonarson, H. Cheng, W. Cloninger, R. Curtis, D. Gejman, P. V. Henskens, F. Mattingsdal, M. Oh, S. Y. Scott, R. Webb, B. Breen, G. Kukull, W. A. Churchhouse, C. Bulik, C. M. Daly, M. Dichgans, M. Faraone, S. V. Guerreiro, R. Holmans, P. Farrer, L. A. Barnes, L. L. Beach, T. G. Demirci, F. Y. Head, E. Hulette, C. M. Jicha, G. A. Kauwe, J. S. K. Kaye, J. A. Leverenz, J. B. Levey, A. I. Lieberman, A. P. Pankratz, V. S. Poon, W. W. Quinn, J. F. Saykin, A. J. Schneider, L. S. Smith, A. G. Sonnen, J. A. Stern, R. A. Van Deerlin, V. M. Van Eldik, L. J. Harold, D. Russo, G. Rubinsztein, D. C. Bayer, A. Tsolaki, M. Proitsi, P. Fox, N. C. Hampel, H. Owen, M. J. Mead, S. Passmore, P. Morgan, K. Nöthen, M. M. Rossor, M. Lupton, M. K. Hoffmann, P. Kornhuber, J. Lawlor, B. McQuillin, A. Al-Chalabi, A.
Issue Date:	2018
Source:	Jun 22 360, (6395), 2018
Journal:	Science
Abstract:	Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.1095-9203Brainstorm Consortium Anttila, Verneri Orcid: 0000-0002-0073-4675 Bulik-Sullivan, Brendan Finucane, Hilary K Orcid: 0000-0003-3864-9828 Walters, Raymond K Orcid: 0000-0001-8422-6530 Bras, Jose Duncan, Laramie Orcid: 0000-0003-1131-661x Escott-Price, Valentina Orcid: 0000-0003-1784-5483 Falcone, Guido J Orcid: 0000-0002-6407-0302 Gormley, Padhraig Orcid: 0000-0002-8908-6968 Malik, Rainer Orcid: 0000-0001-9212-2520 Patsopoulos, Nikolaos A Ripke, Stephan Orcid: 0000-0003-3622-835x Wei, Zhi Orcid: 0000-0001-6059-4267 Yu, Dongmei Orcid: 0000-0001-7901-4365 Lee, Phil H Orcid: 0000-0003-1770-3100 Turley, Patrick Grenier-Boley, Benjamin Chouraki, Vincent Kamatani, Yoichiro Berr, Claudine Letenneur, Luc Hannequin, Didier Amouyel, Philippe Boland, Anne Deleuze, Jean-François Duron, Emmanuelle Vardarajan, Badri N Reitz, Christiane Goate, Alison M Huentelman, Matthew J Kamboh, M Ilyas Larson, Eric B Rogaeva, Ekaterina St George-Hyslop, Peter Hakonarson, Hakon Kukull, Walter A Farrer, Lindsay A Barnes, Lisa L Beach, Thomas G Demirci, F Yesim Head, Elizabeth Hulette, Christine M Jicha, Gregory A Kauwe, John S K Kaye, Jeffrey A Leverenz, James B Levey, Allan I Lieberman, Andrew P Pankratz, Vernon S Poon, Wayne W Quinn, Joseph F Saykin, Andrew J Schneider, Lon S Smith, Amanda G Sonnen, Joshua A Stern, Robert A Van Deerlin, Vivianna M Van Eldik, Linda J Harold, Denise Russo, Giancarlo Rubinsztein, David C Bayer, Anthony Tsolaki, Magda Proitsi, Petra Fox, Nick C Hampel, Harald Owen, Michael J Mead, Simon Passmore, Peter Morgan, Kevin Nöthen, Markus M Rossor, Martin Lupton, Michelle K Hoffmann, Per Kornhuber, Johannes Lawlor, Brian McQuillin, Andrew Al-Chalabi, Ammar Bis, Joshua C Ruiz, Agustin Boada, Mercè Seshadri, Sudha Beiser, Alexa Rice, Kenneth van der Lee, Sven J De Jager, Philip L Geschwind, Daniel H Riemenschneider, Matthias Riedel-Heller, Steffi Rotter, Jerome I Ransmayr, Gerhard Hyman, Bradley T Cruchaga, Carlos Alegret, Montserrat Winsvold, Bendik Palta, Priit Farh, Kai-How Cuenca-Leon, Ester Furlotte, Nicholas Kurth, Tobias Ligthart, Lannie Terwindt, Gisela M Freilinger, Tobias Ran, Caroline Gordon, Scott D Borck, Guntram Adams, Hieab H H Lehtimäki, Terho Wedenoja, Juho Buring, Julie E Schürks, Markus Hrafnsdottir, Maria Hottenga, Jouke-Jan Penninx, Brenda Artto, Ville Kaunisto, Mari Vepsäläinen, Salli Martin, Nicholas G Montgomery, Grant W Kurki, Mitja I Hämäläinen, Eija Huang, Hailiang Huang, Jie Sandor, Cynthia Webber, Caleb Muller-Myhsok, Bertram Schreiber, Stefan Salomaa, Veikko Loehrer, Elizabeth Göbel, Hartmut Macaya, Alfons Pozo-Rosich, Patricia Hansen, Thomas Werge, Thomas Kaprio, Jaakko Metspalu, Andres Kubisch, Christian Ferrari, Michel D Belin, Andrea C van den Maagdenberg, Arn M J M Zwart, John-Anker Boomsma, Dorret Eriksson, Nicholas Olesen, Jes Chasman, Daniel I Nyholt, Dale R Avbersek, Andreja Baum, Larry Berkovic, Samuel Bradfield, Jonathan Buono, Russell J Catarino, Claudia B Cossette, Patrick De Jonghe, Peter Depondt, Chantal Dlugos, Dennis Ferraro, Thomas N French, Jacqueline Hjalgrim, Helle Jamnadas-Khoda, Jennifer Kälviäinen, Reetta Kunz, Wolfram S Lerche, Holger Leu, Costin Lindhout, Dick Lo, Warren Lowenstein, Daniel McCormack, Mark Møller, Rikke S Molloy, Anne Ng, Ping-Wing Oliver, Karen Privitera, Michael Radtke, Rodney Ruppert, Ann-Kathrin Sander, Thomas Schachter, Steven Schankin, Christoph Scheffer, Ingrid Schoch, Susanne Sisodiya, Sanjay M Smith, Philip Sperling, Michael Striano, Pasquale Surges, Rainer Thomas, G Neil Visscher, Frank Whelan, Christopher D Zara, Federico Heinzen, Erin L Marson, Anthony Becker, Felicitas Stroink, Hans Zimprich, Fritz Gasser, Thomas Gibbs, Raphael Heutink, Peter Martinez, Maria Morris, Huw R Sharma, Manu Ryten, Mina Mok, Kin Y Pulit, Sara Bevan, Steve Holliday, Elizabeth Attia, John Battey, Thomas Boncoraglio, Giorgio Thijs, Vincent Chen, Wei-Min Mitchell, Braxton Rothwell, Peter Sharma, Pankaj Sudlow, Cathie Vicente, Astrid Markus, Hugh Kourkoulis, Christina Pera, Joana Raffeld, Miriam Silliman, Scott Boraska Perica, Vesna Thornton, Laura M Huckins, Laura M William Rayner, N Lewis, Cathryn M Gratacos, Monica Rybakowski, Filip Keski-Rahkonen, Anna Raevuori, Anu Hudson, James I Reichborn-Kjennerud, Ted Monteleone, Palmiero Karwautz, Andreas Mannik, Katrin Baker, Jessica H O'Toole, Julie K Trace, Sara E Davis, Oliver S P Helder, Sietske G Ehrlich, Stefan Herpertz-Dahlmann, Beate Danner, Unna N van Elburg, Annemarie A Clementi, Maurizio Forzan, Monica Docampo, Elisa Lissowska, Jolanta Hauser, Joanna Tortorella, Alfonso Maj, Mario Gonidakis, Fragiskos Tziouvas, Konstantinos Papezova, Hana Yilmaz, Zeynep Wagner, Gudrun Cohen-Woods, Sarah Herms, Stefan Julià, Antonio Rabionet, Raquel Dick, Danielle M Ripatti, Samuli Andreassen, Ole A Espeseth, Thomas Lundervold, Astri J Steen, Vidar M Pinto, Dalila Scherer, Stephen W Aschauer, Harald Schosser, Alexandra Alfredsson, Lars Padyukov, Leonid Halmi, Katherine A Mitchell, James Strober, Michael Bergen, Andrew W Kaye, Walter Szatkiewicz, Jin Peng Cormand, Bru Ramos-Quiroga, Josep Antoni Sánchez-Mora, Cristina Ribasés, Marta Casas, Miguel Hervas, Amaia Arranz, Maria Jesús Haavik, Jan Zayats, Tetyana Johansson, Stefan Williams, Nigel Dempfle, Astrid Rothenberger, Aribert Kuntsi, Jonna Oades, Robert D Banaschewski, Tobias Franke, Barbara Buitelaar, Jan K Arias Vasquez, Alejandro Doyle, Alysa E Reif, Andreas Lesch, Klaus-Peter Freitag, Christine Rivero, Olga Palmason, Haukur Romanos, Marcel Langley, Kate Rietschel, Marcella Witt, Stephanie H Dalsgaard, Soeren Børglum, Anders D Waldman, Irwin Wilmot, Beth Molly, Nikolas Bau, Claiton H D Crosbie, Jennifer Schachar, Russell Loo, Sandra K McGough, James J Grevet, Eugenio H Medland, Sarah E Robinson, Elise Weiss, Lauren A Bacchelli, Elena Bailey, Anthony Bal, Vanessa Battaglia, Agatino Betancur, Catalina Bolton, Patrick Cantor, Rita Celestino-Soper, Patrícia Dawson, Geraldine De Rubeis, Silvia Duque, Frederico Green, Andrew Klauck, Sabine M Leboyer, Marion Levitt, Pat Maestrini, Elena Mane, Shrikant De-Luca, Daniel Moreno- Parr, Jeremy Regan, Regina Reichenberg, Abraham Sandin, Sven Vorstman, Jacob Wassink, Thomas Wijsman, Ellen Cook, Edwin Santangelo, Susan Delorme, Richard Rogé, Bernadette Magalhaes, Tiago Arking, Dan Schulze, Thomas G Thompson, Robert C Strohmaier, Jana Matthews, Keith Melle, Ingrid Morris, Derek Blackwood, Douglas McIntosh, Andrew Bergen, Sarah E Schalling, Martin Jamain, Stéphane Maaser, Anna Fischer, Sascha B Reinbold, Céline S Fullerton, Janice M Guzman-Parra, José Mayoral, Fermin Schofield, Peter R Cichon, Sven Mühleisen, Thomas W Degenhardt, Franziska Schumacher, Johannes Bauer, Michael Mitchell, Philip B Gershon, Elliot S Rice, John Potash, James B Zandi, Peter P Craddock, Nick Ferrier, I Nicol Alda, Martin Rouleau, Guy A Turecki, Gustavo Ophoff, Roel Pato, Carlos Anjorin, Adebayo Stahl, Eli Leber, Markus Czerski, Piotr M Cruceanu, Cristiana Jones, Ian R Posthuma, Danielle Andlauer, Till F M Forstner, Andreas J Streit, Fabian Baune, Bernhard T Air, Tracy Sinnamon, Grant Wray, Naomi R MacIntyre, Donald J Porteous, David Homuth, Georg Rivera, Margarita Grove, Jakob Middeldorp, Christel M Hickie, Ian Pergadia, Michele Mehta, Divya Smit, Johannes H Jansen, Rick de Geus, Eco Dunn, Erin Li, Qingqin S Nauck, Matthias Schoevers, Robert A Beekman, Aartjan Tf Knowles, James A Viktorin, Alexander Arnold, Paul Barr, Cathy L Bedoya-Berrio, Gabriel Bienvenu, O Joseph Brentani, Helena Burton, Christie Camarena, Beatriz Cappi, Carolina Cath, Danielle Cavallini, Maria Cusi, Daniele Darrow, Sabrina Denys, Damiaan Derks, Eske M Dietrich, Andrea Fernandez, Thomas Figee, Martijn Freimer, Nelson Gerber, Gloria Grados, Marco Greenberg, Erica Hanna, Gregory L Hartmann, Andreas Hirschtritt, Matthew E Hoekstra, Pieter J Huang, Alden Huyser, Chaim Illmann, Cornelia Jenike, Michael Kuperman, Samuel Leventhal, Bennett Lochner, Christine Lyon, Gholson J Macciardi, Fabio Madruga-Garrido, Marcos Malaty, Irene A Maras, Athanasios McGrath, Lauren Miguel, Eurípedes C Mir, Pablo Nestadt, Gerald Nicolini, Humberto Okun, Michael S Pakstis, Andrew Paschou, Peristera Piacentini, John Pittenger, Christopher Plessen, Kerstin Ramensky, Vasily Ramos, Eliana M Reus, Victor Richter, Margaret A Riddle, Mark A Robertson, Mary M Roessner, Veit Rosário, Maria Samuels, Jack F Sandor, Paul Stein, Dan J Tsetsos, Fotis Van Nieuwerburgh, Filip Weatherall, Sarah Wendland, Jens R Wolanczyk, Tomasz Worbe, Yulia Zai, Gwyneth Goes, Fernando S McLaughlin, Nicole Nestadt, Paul S Grabe, Hans-Jorgen Depienne, Christel Konkashbaev, Anuar Lanzagorta, Nuria Valencia-Duarte, Ana Bramon, Elvira Buccola, Nancy Cahn, Wiepke Cairns, Murray Chong, Siow A Cohen, David Crespo-Facorro, Benedicto Crowley, James Davidson, Michael DeLisi, Lynn Dinan, Timothy Donohoe, Gary Drapeau, Elodie Duan, Jubao Haan, Lieuwe Hougaard, David Karachanak-Yankova, Sena Khrunin, Andrey Klovins, Janis Kučinskas, Vaidutis Lee Chee Keong, Jimmy Limborska, Svetlana Loughland, Carmel Lönnqvist, Jouko Maher, Brion Mattheisen, Manuel McDonald, Colm Murphy, Kieran C Nenadic, Igor van Os, Jim Pantelis, Christos Pato, Michele Petryshen, Tracey Quested, Digby Roussos, Panos Sanders, Alan R Schall, Ulrich Schwab, Sibylle G Sim, Kang So, Hon-Cheong Stögmann, Elisabeth Subramaniam, Mythily Toncheva, Draga Waddington, John Walters, James Weiser, Mark Cheng, Wei Cloninger, Robert Curtis, David Gejman, Pablo V Henskens, Frans Mattingsdal, Morten Oh, Sang-Yun Scott, Rodney Webb, Bradley Breen, Gerome Orcid: 0000-0003-2053-1792 Churchhouse, Claire Bulik, Cynthia M Orcid: 0000-0001-7772-3264 Daly, Mark Orcid: 0000-0002-0949-8752 Dichgans, Martin Orcid: 0000-0002-0654-387x Faraone, Stephen V Orcid: 0000-0002-9217-3982 Guerreiro, Rita Holmans, Peter Orcid: 0000-0003-0870-9412 Kendler, Kenneth S Koeleman, Bobby Orcid: 0000-0001-7749-182x Mathews, Carol A Orcid: 0000-0003-2208-7058 Price, Alkes Scharf, Jeremiah Sklar, Pamela Orcid: 0000-0001-9715-4943 Williams, Julie Orcid: 0000-0002-4069-0259 Wood, Nicholas W Orcid: 0000-0002-9500-3348 Cotsapas, Chris Orcid: 0000-0002-7772-5910 Palotie, Aarno Smoller, Jordan W Orcid: 0000-0002-0381-6334 Sullivan, Patrick Orcid: 0000-0002-6619-873x Rosand, Jonathan Orcid: 0000-0002-1014-9138 Corvin, Aiden Orcid: 0000-0001-6717-4089 Neale, Benjamin M Orcid: 0000-0003-1513-6077 Schott, Jonathan M Anney, Richard Elia, Josephine Grigoroiu-Serbanescu, Maria Edenberg, Howard J Murray, Robin K07 AG043587/AG/NIA NIH HHS/United States 203249/Z/16/Z/WT_/Wellcome Trust/United Kingdom R01 MH100027/MH/NIMH NIH HHS/United States P01 AG026276/AG/NIA NIH HHS/United States MR/N008324/1/MRC_/Medical Research Council/United Kingdom P30 AG021342/AG/NIA NIH HHS/United States P30 AG008017/AG/NIA NIH HHS/United States P30 AG010161/AG/NIA NIH HHS/United States MR/R024804/1/MRC_/Medical Research Council/United Kingdom R01 AG041718/AG/NIA NIH HHS/United States G0401207/MRC_/Medical Research Council/United Kingdom R01 NS017950/NS/NINDS NIH HHS/United States G0800637/MRC_/Medical Research Council/United Kingdom MR/L501529/1/MRC_/Medical Research Council/United Kingdom R01 AG054076/AG/NIA NIH HHS/United States K01 MH109782/MH/NIMH NIH HHS/United States UL1 TR002369/TR/NCATS NIH HHS/United States R25 MH077823/MH/NIMH NIH HHS/United States MR/L010305/1/MRC_/Medical Research Council/United Kingdom Z99 AG999999/ImNIH/Intramural NIH HHS/United States MR/L501554/1/MRC_/Medical Research Council/United Kingdom MC_UU_00024/1/MRC_/Medical Research Council/United Kingdom U01 AG016976/AG/NIA NIH HHS/United States PDA/02/06/016/DH_/Department of Health/United Kingdom P01 AG003991/AG/NIA NIH HHS/United States P50 AG005681/AG/NIA NIH HHS/United States P50 AG005136/AG/NIA NIH HHS/United States G0300189/MRC_/Medical Research Council/United Kingdom U01 MH109536/MH/NIMH NIH HHS/United States R01 MH106490/MH/NIMH NIH HHS/United States R01 MH115961/MH/NIMH NIH HHS/United States P50 AG005133/AG/NIA NIH HHS/United States T32 MH076694/MH/NIMH NIH HHS/United States R01 MH085548/MH/NIMH NIH HHS/United States G0901310/MRC_/Medical Research Council/United Kingdom U24 MH068457/MH/NIMH NIH HHS/United States MR/P005748/1/MRC_/Medical Research Council/United Kingdom R00 MH101367/MH/NIMH NIH HHS/United States J-0901/PUK_/Parkinson's UK/United Kingdom MC_G1000735/MRC_/Medical Research Council/United Kingdom UKDRI-2002/MRC_/Medical Research Council/United Kingdom ALCHALABI-DOBSON/APR14/829-791/MNDA_/Motor Neurone Disease Association/United Kingdom U01 AG052409/AG/NIA NIH HHS/United States R01 AG030653/AG/NIA NIH HHS/United States R01 MH107649/MH/NIMH NIH HHS/United States R01 MH092293/MH/NIMH NIH HHS/United States P30 AG010129/AG/NIA NIH HHS/United States U01 MH094432/MH/NIMH NIH HHS/United States MR/L023784/2/MRC_/Medical Research Council/United Kingdom MR/K026992/1/MRC_/Medical Research Council/United Kingdom U01 AG049505/AG/NIA NIH HHS/United States Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Science. 2018 Jun 22;360(6395):eaap8757. doi: 10.1126/science.aap8757.
DOI:	10.1126/science.aap8757
Keywords:	Genome-Wide Association Study;Brain Diseases/classification/diagnosis/geneticsGenetic Variation;Humans;Mental Disorders/classification/diagnosis/genetics;Phenotype;Quantitative Trait, Heritable;Risk Factors
Type:	Article
Appears in Sites:	Children's Health Queensland Publications

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