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https://dora.health.qld.gov.au/qldresearchjspui/handle/1/1845| Title: | Acute Hemorrhagic Leukoencephalopathy: Pathological Features and Cerebrospinal Fluid Cytokine Profiles | Authors: | Bandodkar, S. Robertson, T. Whitehead, B. Trnka, P. Kothur, K. Dale, R. C. Malone, S. Wienholt, L. Waak, M. Sinclair, K. Phillips, G. |
Issue Date: | 2019 | Source: | 100 , 2019, p. 92-96 | Pages: | 92-96 | Journal: | Pediatric Neurology | Abstract: | Background: Acute hemorrhagic leukoencephalopathy is a rare encephalopathy of unknown etiology, causing fulminant, hemorrhagic central nervous system demyelination with high mortality. It is unclear whether acute hemorrhagic leukoencephalopathy is an entirely distinct entity from acute disseminated encephalomyelitis. Patients and Methods: We report two patients with rapidly progressive neurological illness resulting in raised intracranial pressure and coma, with biopsy-proven acute hemorrhagic leukoencephalopathy (perivascular hemorrhages and demyelination, predominantly neutrophil infiltrates). Results: Acute cerebrospinal fluid showed pronounced T cell-associated cytokine elevation (interleukins 6, 8, and 17A) and CCL2 or CCL3, higher than in patients with acute disseminated encephalomyelitis, but no B cell-associated cytokine elevation. Conclusion: Improved understanding of the immune process may provide rationale for use of anticytokine biologic agents.L20024392742019-08-06 | DOI: | 10.1016/j.pediatrneurol.2019.06.013 | Resources: | https://www.embase.com/search/results?subaction=viewrecord&id=L2002439274&from=exporthttp://dx.doi.org/10.1016/j.pediatrneurol.2019.06.013 | | Keywords: | macrophage inflammatory protein 1alpha;methylprednisolone;monocyte chemotactic protein 1;rheumatoid factor;thymus and activation regulated chemokine;tumor necrosis factor;acute disseminated encephalomyelitis;acute hemorrhagic leukoencephalopathy;adolescent;antibody titer;article;B lymphocyte;brain biopsy;brain edema;cerebrospinal fluid analysis;clinical article;clinical feature;coma;computer assisted tomography;cytokine production;death;decompressive craniectomy;demyelination;endotracheal intubation;erythrocyte count;erythrocyte sedimentation rate;fever;glioma;headache;histopathology;human;human cell;human tissue;image analysis;intracranial hypertension;laboratory test;leukocyte count;leukoencephalopathy;male;mononuclear cell;neurologic disease;neutrophil chemotaxis;neutrophilia;nuclear magnetic resonance imaging;obstructive hydrocephalus;osmosis;photophobia;plasma exchange;platelet count;pleocytosis;polymerase chain reaction;polymorphonuclear cell;serology;T lymphocyte;treatment response;vomiting;priority journal;cerebrospinal fluid drainage systemantinuclear antibody;C reactive protein;complement component C3;complement component C4;corticosteroid derivative;CXCL11 chemokine;CXCL9 chemokine;cyclophosphamide;cytokine;dexamethasone;gamma interferon;gamma interferon inducible protein 10;granulocyte colony stimulating factor;immunoglobulin;immunoglobulin M;interleukin 10;interleukin 13;interleukin 17;interleukin 4;interleukin 6;interleukin 8;lactic acid;lupus anticoagulant | Type: | Article |
| Appears in Sites: | Children's Health Queensland Publications |
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