Please use this identifier to cite or link to this item: https://dora.health.qld.gov.au/qldresearchjspui/handle/1/12231
Title: Retinoblastoma outcomes in Europe: a prospective analysis of 483 patients from 40 countries
Authors: Bowman, R.;Arazi, M.;Cassoux, N.;Foster, A.;Gomel, N.;Kapelushnik, N.;MacLeod, D.;Fabian, I. D.;Zondervan, M.;Ziko, O. A. O.;Zia, N.;Zhilyaeva, K.;Zheng, X.;Zhao, J.;Zhang, Y.;Zhang, C.;Zein, E.;Zapata López, A. M.;Yuliawati, P.;Yousef, Y. A.;Ye, H.;Yarovoy, A. A.;Yarovaya, V. A.;Yaqub, M. A.;Yanga, J. M.;Yang, H.;Yam, J. C.;Xiao, Y.;Xiang, D.;Wongwai, P.;Dod, C. W.;Wiwatwongwana, D.;Wiwatwongwana, A.;Wime, A. D. C.;Wilson, M. W.;Weiss, A.;Wang, Y. Z.;Wali Nigeria, A. H.;Wade, P. D.;Waddell, K.;Wackernagel, W.;Wachtel, A. E.;Vora, T.;Vishnevskia-Dai, V.;Villacís Chafla, E. G.;Viksnins, M.;Victor, A. A.;Verma, N.;Veleva-Krasteva, N. V.;Vaughan, L. O.;Vasquez, L.;Varadisai, A.;van Hoefen Wijsard, M.;Valeina, S.;Usmanov, R. H.;Ushakova, T. L.;Urbak, S. F.;Uner, O. E.;Unal, E.;Umar, A. B.;Tyau-Tyau, H.;Tuncer, S.;Trichaiyaporn, S.;Traoré, F.;Trang, D. L.;Toledano, H.;Theophile, T.;Teh, K. H.;Teixeira, L. F.;Tehuteru, E. S.;Tateshi, B.;Tashvighi, M.;Tarrillo Leiva, F. F.;Tandili, A.;Tan, D.;Tamamyan, G.;Sylla, F.;Svojgr, K.;Suzuki, S.;Surukrattanaskul, S.;Supriyadi, E.;Superstein, R.;Sundy, M.;Sun, X.;Sultana, S.;Suarez, M. E. C.;Strahlendorf, C.;Stones, D. K.;Kranjc, B. S.;Stathopoulos, C.;Stahl, E. D.;Staffieri, S. E.;Stacey, A. W.;Ssali, G.;Sorochynska, T.;Soebagjo, H. D.;Skalet, A. H.;Sitorus, R. S.;Singha, P.;Singh, U.;Singh, N.;Singh, A. D.;Silva, S. ;Cheikh, S. S.;Siddiqui, S. N.;Shields, C. L.;Shetye, N. G.;Sherief, S. T.;Sharma, M. K.;Shakoor, S. A.;Shah, A. S. ;Seth, R.;Seregard, S.;Sedaghat, A.;Schoeman, J.;Schefler, A. C.;Scanlan, T. A.;Sayalith, P.;Sánchez F, G. L.;Pacheco, S. S. R.;Salas, B.;Saiju, R.;Said, A. M. A.;Sagoo, M. S.;Sabhan, A. H.;Saakyan, S.;Saab, R. H.;Roy, S. R.;Romero, L.;Rojanaporn, D.;Ritter-Sovinz, P.;Riheia, M. M.;Ribadu, D.;Reynders, D.;Renner, L. A.;Reich, E.;Reddy, M. A.;Rashid, R.;Raobela, L.;Ramirez-Ortiz, M. A.;Ramasubramanian, A.;Ramanjulu, R.;Rajkarnikar, P.;Rahmat, J.;Rahman, S. ;Rahman, A.;Qian, J.;Qayyum, S.;Qadir, A. O.;Purwanto, I.;Prom, V.;Prat, D.;Pons, J. J.;Pompe, M. T.;Polyakov, V. G.;Polania, R. A.;Pochop, P.;Plager, D. A.;Philbert, R.;Pham, C. T. M.;Perić, S.;Peña, A.;Pe’er, J.;Pawinska-Wasikowska, K.;Paton, K. E.;Pascual Morales, C. R.;Parulekar, M.;Parrozzani, R.;Papyan, R.;Palanivelu, M. S.;Pal, B. P.;Paiva, L.;Paintsil, V.;Painter, S. L.;Pagarra, H.;Paez-Escamilla, M. A.;Ossandon, D.;Osei-Bonsu, P.;Oliver, S. C. N.;Olechowski, A.;Oguego, N. C.;Obono-Obiang, G.;Nyaywa, M.;Nuruddin, M.;Nkumbe, H.;Nkanga, E. D.;Nikitovic, M.;Nieves, R. M.;Ngo, H.;Neroev, V.;Nency, Y. M.;Roth, P. A. N.;Naumenko, L.;Nair, A. G.;Naidu, G.;Muyen, O. M.;Mustak, H.;Mushtaq, A.;Musa, K. O.;Murray, T. G.;Murgoi, G.;Munier, F. L.;Muma, K. I.;Mudaliar, S. S.;Msukwa, G.;Msina, M. S.;Mruthyunjaya, P.;Moreira, C.;Morales, R. A.;Montero, M. M.;Moll, A. C.;Mohammad, M. T.;Mohamedani, A. A.;Mndeme, F. G.;Mishra, D. K. C.;Midena, E.;Mets, M. B.;Mercado, G. J. V. D. S.;Menon, V.;Mengesha, A. A.;Mehrvar, A.;Medina-Sanson, A.;McKenzie, J. D.;Paed, M.;Mbumba, F. B.;Mayet, I.;Matua, M.;Mattosinho, C. C. D. S.;Materin, M.;Matende, I. O.;Mason, J. O.;Mason, L.;Begue, N. M.;Manda, C.;Makimbetov, E. K.;Makan, M.;Maka, E.;Majeed, A. R.;Mahajan, A.;Magrath, G. N.;Lysytsia, L.;Lutfi, D.;Luna-Fineman, S.;Lumbroso, L.;Lukamba, R. M.;López, J. P.;Long, Q. B.;Limbu, B.;Li, C.;Leverant, A. A.;Lecuona, K.;Le, B. H. A.;Laurenti, K. D.;Latinović, S.;Larson, S. A.;Lam, G. C.;Lam, C. P. S.;Lachmann, E. S.;Kyara, A.;Kuntorini, M. W.;Kulvichit, K.;Kruger, M.;Krivaitiene, D.;Palet, J. E. K. K.;Klett, A.;Kivelä, T. T.;Kiratli, H.;Kim, J. H.;Kim, J. W.;Khotenashvili, Z.;Khodabande, A.;Khetan, V.;Kheir, W. J.;Phara, K.;Khaqan, H. A.;Khan, Z. J.;Keren-Froim, N.;Kepak, T.;Kebudi, R.;Kardava, T.;Kao, L. Y.;Kantar, M.;Kalinaki, A.;Kaliki, S.;Kabore, R. L.;Amani Kabesha, T. B.;Jones, M. M.;Johnson, W. J.;Johnson, K. P.;Jo, D. H.;Ji, X.;Jenkinson, H.;Jeeva, I.;Jairaj, V.;Ilic, V. R.;Ida, R.;Hussein Al-Janabi, A. N.;Husakova, K.;Hummlen, M.;Hubbard, G. B.;Huang, L. C.;Hordofa, D. F.;Hessissen, L.;Hernandez, L. M. C.;Hernandez, J.;Hederova, S.;Hassan, S.;Hasanreisoglu, M.;Hartnett, M. E.;Harbour, J. W.;Hansen, E. D.;Hamzah, N.;Hamid, S. A.;Hamel, P.;Hadjistilianou, T.;Gupta, S.;Gupta, H.;Gündüz, A. K.;Gunasekera, D. S.;Guedenon, K. M.;Grigorovski, N. D. A. K.;Gregersen, P. A.;Green, L.;Graells, J.;Garcia Pacheco, H. N.;González-Rodríguez, L.;Perez, G. G.;Gonzalez, E.;Gole, G. A.;Goldberg-Lavid, M.;Gold, A. S.;Goenz, M. A.;Gizachew, Z.;Girón, A. V.;Gilbert, C.;Ghassemi, F.;Geel, J. A.;Gassant, P. Y.;Aldana, D. G.;Garcia, J. L.;Gandiwa, M.;Gallie, B. L.;Fuentes-Alabi, S. L.;Fu, L. D.;Frenkel, S.;Fernández-Teijeiro, A.;Fernández, D. D. P. G.;Fasina, O.;Faranoush, M.;Fandiño, A. C.;Fadoo, Z.;Evina, T. G. A.;Essuman, V. A.;Elzembely, M. M.;Ali Elhassan, M. M.;Elhaddad, A. M.;Elgalaly, D.;Elder, J. E.;Elbahi, A. M.;Kettani, A. E. L.;Sutyawan, I. W. E.;Edison, K. S.;Bruyn, M. D.;Du, Y.;Dragomir, M. D.;Donato Macedo, C. R.;Donaldson, C.;Phil, M.;Dodgshun, A. J.;Dimaras, H.;Diaz Coronado, R. Y.;Desjardins, L.;Demirci, H.;Delgado, K. Q.;Potter, P. D.;Davidson, A.;Davanzo, J. M.;Das, S.;Das, A.;Dangboon, W.;Da Gama, I. V.;Cui, X.;Csóka, M.;Cowan-Lyn, K. E.;Corson, T. W.;Correa Llano, M. G.;Correa, Z. M.;Comsa, C.;Cockcroft, R. L.;Cieslik, K.;Chuluunbat, T.;Chiwanga, F. S.;Chernodrinska, V. S.;Chawla, B.;Chauhan, A.;Chaugule, S. S.;Chaudhry, S.;Chantada, G. L.;Català-Mora, J.;Castillo, L.;Castela, G.;Michael Capra, F. R. C. P. I.;Cano, M. R.;Camuglia, J. E.;Calle Jara, D. A.;Calderón-Sotelo, P.;Buaboonnam, J.;Brichard, B. G.;Brennan, R. C.;Boumedane, A.;Bouguila, H.;Bouda, G. C.;Bornfeld, N.;Bonanomi, M. T. B. C.;Boldt, H. C.;Boehme, M.;Bobrova, N.;Blum, S. ;Biewald, E. M.;Biddulph, S. J.;Bhat, S.;Bhaduri, A.;Berry, J. L.;Berete, R. C.;Guebessi, N. B.;Benmiloud, S.;Benavides, R.;Popovic, M. B.;Bascaran, C.;Barranco, H.;Balwierz, W.;Balayeva, R.;Balaguer, J.;Baizakova, B.;Ayala, S.;Aung, T. H.;Attaseth, T.;Atsiaya, R.;Atchaneeyasakul, L. O.;Atalay, H. T.;Astbury, N. J.;Antonino, R.;Amiruddin, P. O.;Al-Shammary, E. H.;Al-Shaheen, A. A. S. M.;Alsawidi, K. M.;Almeida, A. A.;Al-Mafrachi, A. A. R. M.;All-Eriksson, C.;Alkatan, H. M.;Al-Jumaly, U.;Al-Jadiry, M. F.;Alia, D. B.;Ali, A. M.;Al-Hussaini, H. H. Y.;Al-Haddad, C.;Carreras, Y. A.;Alfa Bio, A. I.;Alemany-Rubio, E.;Alejos, A.;Al-Dahmash, S. A.;Alcasabas, A. P. A.;Al-Badri, S. A. F.;Portabella, S. A.;Alakbarova, A.;Al Ani, M. H.;Harby, L. A.;Akib, M. N. R.;Ahmad, A.;Aghaji, A. E.;Aggarwal, P.;Afshar, A. R.;Adio, A.;Ademola-Popoola, D. S.;Sahadatou, A. B.;Abdulqader, R. A.;Abdullahi, S. U.;Abdallah, E.
Issue Date: 2025
Source: Eye (Basingstoke), 2025
Journal Title: Eye (Basingstoke)
Abstract: Purpose: To describe presentation, treatment and outcomes for a cohort of children presenting with retinoblastoma (Rb) throughout Europe during 2017. Methods: A prospective analysis of 483 patients diagnosed in Europe between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Results: Unilateral cases 339/483 (70%) predominated, presenting older (mean age 26 months) than the 144 (30%) bilateral cases (mean age 12 months p < 0.0005). Only 4/477 (0.8%) children had extra-ocular Rb at presentation (mean age 53 months vs 21 months for those without p = 0.002). Children from middle income countries did not present older, but were more likely (p < 0.001) to present with late-stage disease (3-4) than high-income children (74/151 (49%) vs 108/332 (33%), RR 1.25 95%CI 1.09–1.44). For unilaterals, primary treatment was intravenous chemotherapy (IVC) in 29% and intra-arterial chemotherapy (IAC) in 20%. For bilaterals, primary treatment was IVC in 113/144 (78%) and IAC in 14/144 (10%). Overall, 58% of children underwent enucleation, 36% of which as primary treatment. Risk of enucleation was determined by stage and laterality, but not economic status. Twelve (2.5%) children died from Rb. More children (OR = 146-7 13.9–1549.4, p < 0.0005) presenting with extra-ocular tumour died (3 of 4 (75%)) than with intra-ocular tumour (9/449 (2%)) More children (OR = 29.8 3.8–232.0, p < 0.0005), from middle income countries died from Rb (11/132 (8%)) than from high income countries (1/327 (0.3%)). Conclusion: Even within a wealthy continent such as Europe, economic factors may influence survival, but not global salvage rates. The majority of children still lose an eye.
DOI: 10.1038/s41433-025-04144-y
Resources: https://www.embase.com/search/results?subaction=viewrecord&id=L2041883089&from=export
http://dx.doi.org/10.1038/s41433-025-04144-y
Type: Article in Press
Appears in Sites:Children's Health Queensland Publications
Queensland Health Publications

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