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https://dora.health.qld.gov.au/qldresearchjspui/handle/1/11356| Title: | Antibody responses against influenza A decline with successive years of annual influenza vaccination | Authors: | Sullivan, S. G.;Khvorov, A.;Carolan, L.;Dowson, L.;Hadiprodjo, A. J.;Sánchez-Ovando, S.;Liu, Y.;Leung, V. K. Y.;Hodgson, D.;Blyth, C. C.;Macnish, M.;Cheng, A. C.;Haugenauer, M.;Clark, J. ;Dougherty, S. ;Macartney, K.;Koirala, A.;Khatami, A.;Jadhav, A.;Marshall, H.;Riley, K. E.;Wark, P. A. B.;Delahunty, C.;Subbarao, K.;Kucharski, A. J.;Fox, A. | Issue Date: | 2025 | Source: | NPJ Vaccines, 2025 (10) 1 p.11 | Pages: | 11 | Journal Title: | NPJ Vaccines | Abstract: | Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around Australia during 2020-2021. Sera were collected pre-vaccination and ~14 and ~180 days post-vaccination and assessed in haemagglutination inhibition assay against egg-grown vaccine and equivalent cell-grown viruses. Responses to vaccination were compared by the number of prior vaccinations. Baseline sera were available for 595 HCW in 2020 and 1031 in 2021. 5% had not been vaccinated during five years prior to enrolment and 55% had been vaccinated every year. Post-vaccination titres for all vaccine antigens were lowest among HCW vaccinated in all 5-prior years and highest among HCW with 0 or 1 prior vaccinations, even after adjustment. This was observed for both influenza A subtypes and was dependent on pre-vaccination titre. Expanded cohorts are needed to better understand how this translates to vaccine effectiveness. | DOI: | 10.1038/s41541-024-01057-x |
| Appears in Sites: | Children's Health Queensland Publications Queensland Health Publications |
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