https://dora.health.qld.gov.au/qldresearchjspui/handle/1/5412 Queensland Health Publications 2026-06-18T15:13:10Z https://dora.health.qld.gov.au/qldresearchjspui/handle/1/11095 Title: Melioidosis: An Australian Perspective Authors: Smith, Simon; Hanson, Josh; Currie, Bart J Abstract: Burkholderia pseudomallei is endemic in northern Australia, with cases of melioidosis most commonly occurring during the wet season in individuals with diabetes, hazardous alcohol use, and chronic kidney disease. Pneumonia is the most common presentation and the majority of patients are bacteraemic-however, infection may involve almost any organ, with the skin and soft tissues, genitourinary system, visceral organs, and bone and joints affected most commonly. Central nervous system involvement is rarer, but has a high attributable mortality. Increased awareness of the disease amongst healthcare providers, ready access to appropriate antibiotic therapy and high-quality intensive care services has resulted in a sharp decline in the case fatality rate over the last 20 years. Further improvement in clinical outcomes will require a greater understanding of the disease's pathophysiology, its optimal management, and more effective strategies for its prevention. Description: Cairns & Hinterland Hospital and Health Service (CHHHS) affiliated authors: Simon Smith, Josh Hanson 2018-01-01T00:00:00Z https://dora.health.qld.gov.au/qldresearchjspui/handle/1/11091 Title: International Fragility Fracture Network Delphi consensus statement on the principles of anaesthesia for patients with hip fracture Authors: White, S. M.; Altermatt, F.; Barry, J.; Ben-David, B.; Coburn, M.; Coluzzi, F.; Degoli, M.; Dillane, D.; Foss, N. B.; Gelmanas, A.; Griffiths, R.; Karpetas, G.; Kim, J. H.; Kluger, M.; Lau, P. W.; Matot, I.; McBrien, M.; McManus, S.; Montoya-Pelaez, L. F.; Moppett, I. K.; Parker, M.; Porrill, O.; Sanders, R. D.; Shelton, C.; Sieber, F.; Trikha, A.; Xuebing, X. Description: Cairns & Hinterland Hospital and Health Service (CHHHS) affiliated author: J. Barry 2018-01-01T00:00:00Z https://dora.health.qld.gov.au/qldresearchjspui/handle/1/11089 Title: Mycoplasma genitalium in the Far North Queensland backpacker population: An observational study of prevalence and azithromycin resistance Authors: Trevis, T.; Gossé, M.; Santarossa, N.; Tabrizi, S.; Russell, D.; McBride, W. J. Abstract: BACKGROUND: Mycoplasma genitalium is a sexually transmitted infection (STI), and a common cause of non-gonococcal urethritis (NGU). There is concern regarding the rise in prevalence of M. genitalium and rates of resistance to macrolide antibiotics. International backpackers represent a unique population that may be at an increased risk of STIs. The purpose of this study was to determine the prevalence of M. genitalium and antibiotic resistance in international backpackers. METHODS: First void urine samples were obtained utilising opportunistic sampling from 294 non-treatment-seeking international backpackers at a variety of hostels in Cairns, Queensland Australia. Participants also answered a fixed-answer survey regarding sociodemographic characteristics and sexual risk behaviours. Samples were tested for M. genitalium, Chlamydia trachomatis and Neisseria gonorrhoeae using polymerase chain reaction (PCR). Samples positive for M. genitalium were investigated for macrolide resistance-associated mutations in the 23S rRNA genome at positions A2058G, A2058C, A2058T, A2059G and A2059C (Escherichia coli numbering). RESULTS: Of the 294 samples, 23 failed the internal control. The prevalence of M. genitalium was 1.8% (5/271, 95% confidence interval [CI] ± 1.58), C. trachomatis was 4.1% (11/271, 95% CI ± 2.36) and N. gonorrhoeae was not detected. Macrolide resistance-associated mutations were identified in 40% (2/5) of M. genitalium-positive samples. M. genitalium infection was associated with reporting symptoms (odds ratio [OR] 14.36, 95% CI 2.17-94.94, p < 0.05). CONCLUSIONS: M. genitalium and C. trachomatis are relatively common amongst non-treatment seeking international backpackers, but may not differ from Australian population prevalence. This article provides evidence to further support the increased utilisation of M. genitalium PCR in the diagnosis of NGU, and for macrolide resistance testing for all identified M. genitalium infections. 2018-01-01T00:00:00Z https://dora.health.qld.gov.au/qldresearchjspui/handle/1/11092 Title: Clinically relevant improvements achieved from a facilitated implementation of a gestational diabetes model of care Authors: Wilkinson, S. A.; McCray, S. J.; Kempe, A.; Sellwood, B. Abstract: AIM: Medical nutrition therapy is a cornerstone treatment in gestational diabetes; however, most Australian women diagnosed with gestational diabetes do not receive this. The project evaluated adaptation of a successful evidence-based gestational diabetes model of care implementation from a tertiary centre into regional sites with varied demographics, population size and service capacity. METHODS: The project used a hub (project team)-spoke (sites) model in Far North Queensland (Site 1) and regional South-East Queensland (Site 2). Sites selected demonstrated strong gestational diabetes team cohesiveness and project commitment. The project phases were consultation, baseline, transition and implementation. A best practice decision tree tool was provided to assess/manage barriers to the model of care and clinical outcomes captured through a project database. RESULTS: Role clarification of site members, management engagement, site visits, decision tree and database refinement were completed in the project's first phase. Unexpected organisational and team barriers prevented timeline implementation as planned. Sites negotiated relevant reallocation of resources to achieve project deliverables. The proportion of women seen according to best practice increased from 3.5 to 87.8% (P < 0.001) (Site 1) and nil to 4.8% (P = 0.09) (Site 2), and those on medication dropped by 3.4 (Site 1) and 9.1% (Site 2). CONCLUSIONS: This project demonstrates a successful implementation using a facilitated and rigorous approach. Support, engagement and tools at many levels were keys to success at both sites. The present study illustrates the opportunities and challenges of conducting implementation research within routine clinical care, particularly in resource-challenged sites. Description: Cairns & Hinterland Hospital and Health Service (CHHHS) affiliated authors: Alison Kempe, Bernadette Sellwood 2018-01-01T00:00:00Z